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A kind of preparation method of medical device introduction lubricant

A technology for medical devices and lubricants, which is applied in the field of preparation of lubricants introduced into medical devices, which can solve the problems of cavity tissue damage, large frictional resistance, patient pain, etc., and achieve improved compatibility, controllable viscosity, and low preparation costs Effect

Inactive Publication Date: 2020-06-19
东莞御治医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because it is a hydrophobic material, it will produce greater frictional resistance when used, which will easily cause damage to blood vessels and cavity tissues and cause other inflammations, which often bring pain to patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of lubricant for medical device introduction, by weight, comprises the following components:

[0029] 5 parts of glycerin, 0.5 parts of xanthan gum,

[0030] 10 parts of simethicone oil, 0.05 part of potassium sorbate,

[0031] 0.1 parts of edible essence, 84.35 parts of purified water,

[0032] Its preparation method comprises the following steps:

[0033] (1) Mix chromium trioxide and deionized water, stir at a temperature of 10-15°C and a stirring speed of 1000r / min until the solid dissolves, then add concentrated sulfuric acid drop by drop while stirring, and continue stirring after the dropwise addition 30min, make solution A; Wherein, the consumption ratio of dichromium trioxide and deionized water is 2.35g:40mL, the volume ratio of concentrated sulfuric acid and deionized water is 1:13;

[0034] (2) Mix and stir polyethylene glycol monomethyl ether and absolute ethanol until the solid dissolves, then slowly add the solution A prepared in step (1) dropwi...

Embodiment 2

[0041] A kind of lubricant for medical device introduction, by weight, comprises the following components:

[0042] 3 parts of glycerin, 0.1 part of xanthan gum,

[0043] 8 parts of simethicone oil, 0.03 part of potassium sorbate,

[0044] 0.1 parts of edible essence, 80 parts of purified water,

[0045]Its preparation method comprises the following steps:

[0046] (1) Mix chromium trioxide and deionized water, stir at a temperature of 10-15°C and a stirring speed of 1000r / min until the solid dissolves, then add concentrated sulfuric acid drop by drop while stirring, and continue stirring after the dropwise addition 30min, make solution A; Wherein, the consumption ratio of dichromium trioxide and deionized water is 2.35g:40mL, the volume ratio of concentrated sulfuric acid and deionized water is 1:13;

[0047] (2) Mix and stir polyethylene glycol monomethyl ether and absolute ethanol until the solid dissolves, then slowly add the solution A prepared in step (1) dropwise, st...

Embodiment 3

[0054] A kind of lubricant for medical device introduction, by weight, comprises the following components:

[0055] 6 parts of glycerin, 0.5 parts of xanthan gum,

[0056] 12 parts of simethicone, 0.07 parts of potassium sorbate,

[0057] 0.3 parts of edible essence, 85 parts of purified water,

[0058] Its preparation method comprises the following steps:

[0059] (1) Mix chromium trioxide and deionized water, stir at a temperature of 10-15°C and a stirring speed of 1000r / min until the solid dissolves, then add concentrated sulfuric acid drop by drop while stirring, and continue stirring after the dropwise addition 30min, make solution A; Wherein, the consumption ratio of dichromium trioxide and deionized water is 2.35g:40mL, the volume ratio of concentrated sulfuric acid and deionized water is 1:13;

[0060] (2) Mix and stir polyethylene glycol monomethyl ether and absolute ethanol until the solid dissolves, then slowly add the solution A prepared in step (1) dropwise, st...

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Abstract

The invention discloses a preparation method of a medical apparatus guiding lubricant. The preparation method comprises the following steps: firstly, preparing dimethicone; weighing glycerol, xanthan gum, the dimethicone, potassium sorbate, edible essence and purified water according to dosages of the various components; pouring the various weighed raw materials into a mixing barrel, uniformly stirring at a rotating speed of 600r / min for 20min so as to obtain mixed liquid, and pouring the mixed liquid into a bottling machine for bottling; and then, putting the bottled mixed liquid into a plastic sealed bag, sealing the bag at 200 DEG C, putting the sealed product (the lubricant) and specification into a paper box, and implementing irradiation sterilization, so that the medical apparatus guiding lubricant is prepared. The medical apparatus guiding lubricant provided by the invention can take a good lubricating effect when used for guiding an apparatus, and the medical apparatus guiding lubricant is free from corrosion to the surface of the apparatus, good in chemical stability and harmless to human body.

Description

Technical field: [0001] The invention relates to the field of biomedical materials, in particular to a preparation method of a lubricant introduced into a medical device. Background technique: [0002] The use of medical devices is very large, and the scope of use is also very wide. With the development of modern science and technology, the role of medical devices in modern medical diagnosis is becoming more and more obvious. However, the clinical requirements for medical devices are very strict, because they often need to be in contact with human skin, tissues, body fluids, etc. during use, and some need to be implanted in the body for a long time, which requires the catheter itself not only to meet In addition to the requirements of biomechanical properties, it also has good blood compatibility, lubricity, tissue compatibility and biocompatibility. [0003] The current domestic medical device materials are mostly hydrophobic materials, such as polyvinyl chloride, silicon...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/04B01J31/02B01J31/26C08G77/08
CPCA61L31/042A61L31/06A61L2400/10B01J31/0227B01J31/26C08G77/08C08L83/04C08L5/00
Inventor 赵志豪
Owner 东莞御治医疗器械有限公司
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