Veterinary elliprine injection and preparation method thereof
A technology for injection and water for injection, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve problems such as poor curative effect, poor stability, and strong acidity of injections, and achieve The effect of promoting feasibility, good stability, and simple operation of the preparation process
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Embodiment 1
[0046] The formula of veterinary elliprine injection is as shown in table 1, and its preparation method is as follows:
[0047] (1) 10g of Erdipoline crude drug is placed in a beaker according to the formula quantity, and a mixed solvent composed of 30g of water for injection and 25g of propylene glycol is added, mixed and stirred evenly, and a suspension solution is made;
[0048] (2) Add 16g of hydrochloric acid aqueous solution (10% by weight) to the suspension solution prepared in step (1), and stir evenly, heat in a water bath at 40 to 50°C for 10min, and stir while heating to make the raw material of Erdipoline The drug is fully dissolved;
[0049] (3) Place the solution prepared in step (2) at room temperature for a period of time, add disodium hydrogen phosphate aqueous solution (0.17% by weight) drop by drop to adjust the pH value to between 6.20 and 6.50, and then add 0.18 g of preservative Nipole Gold ethyl ester was supplemented with water for injection to a full ...
Embodiment 2
[0054] The formula of veterinary elliprine injection is as shown in table 2, and its preparation method is as follows:
[0055] (1) 10g of Erdipoline crude drug is placed in a beaker according to the formula quantity, and a mixed solvent composed of 30g of water for injection and 25g of propylene glycol is added, mixed and stirred evenly, and a suspension solution is made;
[0056] (2) Add 18 g of hydrochloric acid aqueous solution to the suspension solution prepared in step (1), and stir evenly, heat in a water bath at 40-50° C. for 10 min, and stir while heating to fully dissolve;
[0057] (3) Place the solution prepared in step (2) at room temperature for a period of time, add disodium hydrogen phosphate solution drop by drop to adjust the pH value to between 6.20 and 6.50; Make up to the full amount of 100g, and finally filter and sterilize through 0.45 μm and 0.22 μm microporous membranes respectively, fill in ampoules, seal and sterilize with circulating steam at 100°C f...
Embodiment 3
[0062] The formula of veterinary elliprine injection is shown in table 3, and its preparation method is as follows:
[0063] (1) 10g of Erdipoline crude drug is placed in a beaker according to the formula quantity, and a mixed solvent composed of 30g of water for injection and 25g of propylene glycol is added, mixed and stirred evenly, and a suspension solution is made;
[0064] (2) Add 20 g of hydrochloric acid aqueous solution to the suspension solution prepared in step (1), and stir evenly, heat in a water bath at 40-50° C. for 10 min, and stir while heating to fully dissolve;
[0065] (3) Place the solution prepared in step (2) at room temperature for a period of time, add disodium hydrogen phosphate solution drop by drop to adjust the pH value to between 6.20 and 6.50; Make up to the full amount of 100g, filter and sterilize through 0.45 μm and 0.22 μm microporous membranes respectively, then fill in ampoules, seal and sterilize with circulating steam at 100°C for 30 minu...
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