A kind of microsponge medical dressing and preparation method thereof
A micro-sponge and medical technology, which is applied in the fields of pharmaceutical formula, medical science, bandages, etc., can solve the problems of difficulty in guaranteeing the protective effect of epidermal growth factor, difficulty in ensuring the uniformity and effectiveness of materials, and doubtful preparation stability, so as to avoid chemical The use of cross-linking agents, the retention of excellent performance, and the effect of reducing residues
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Embodiment 1
[0034] 【prescription】
[0035]
[0036]
[0037] 【preparation】
[0038] Take sodium alginate and sodium carboxymethyl cellulose, add 100ml of deionized water, fully swell and stir to obtain a uniform solution A, take chitosan, add 20ml of deionized water, and stir until a uniform solution B is obtained. Slowly add the polymer solution A into the continuously stirring butyl acetate containing 0.2% Tween 80, fully stir at 800rpm for 30min until the droplets are evenly dispersed, add 10% calcium chloride solution dropwise to the dispersing device, and fully stir at 800rpm for 15min Immediately thereafter, solution B was added and stirring was continued for 30 min. Move the reaction system to a rotary evaporator, and evaporate for about 20 minutes at 37°C and -0.1 MPa until fine foam no longer occurs, and a suspension containing prefabricated microsponges is obtained. The resulting suspension was filtered with a suction filtration device, and ethanol was slowly added to wa...
Embodiment 2
[0040] 【prescription】
[0041]
[0042] 【preparation】
[0043] Take sodium alginate and sodium carboxymethyl cellulose, add 100ml of deionized water, fully swell and stir to obtain a uniform solution A, take chitosan, add 20ml of deionized water, and stir until a uniform solution B is obtained. Slowly add polymer solution A to 100ml of continuously stirring ethyl acetate containing 0.7% Tween 80, fully stir at 1000rpm for 30min until the droplets are uniformly dispersed, add 10% calcium chloride solution dropwise to the dispersion system, and fully stir at 1000rpm After 15 minutes, solution B was added immediately, and stirring was continued for 30 minutes. Move the reaction system to a rotary evaporator, and evaporate for 20 minutes at 37°C and -0.1 MPa until fine foam no longer occurs, and a suspension containing prefabricated microsponges is obtained. The resulting suspension was filtered with a suction filtration device. During the suction filtration, ethanol was slow...
Embodiment 3
[0045] 【prescription】
[0046]
[0047] 【preparation】
[0048] Take sodium alginate and sodium carboxymethyl cellulose, add 100ml of deionized water, fully swell and stir to obtain a uniform solution A, take chitosan, add 20ml of deionized water, and stir until a uniform solution B is obtained. Slowly add polymer solution A to 100ml of continuously stirring butyl acetate containing 0.5% Tween 80, fully stir at 1500rpm for 30min, and after the solution is uniformly dispersed into droplets, add 10% calcium chloride solution dropwise to the dispersion system, After fully stirring at 1500rpm for 15min, solution B was added immediately, and stirring was continued for 30min. Move the reaction system to a rotary evaporator, and evaporate at 40°C at -0.1 MPa for 20 minutes until fine foam no longer occurs, and a suspension containing prefabricated microsponges is obtained. The resulting suspension was filtered with a suction filtration device. During the suction filtration, ethan...
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Abstract
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