Alcohol precipitation tank and horizontal spiral centrifugal machine combined system

Abstract

The invention discloses an alcohol precipitation tank and horizontal spiral centrifugal machine combined system which is mainly composed of an alcohol precipitation tank, a horizontal spiral centrifugal machine and a material conveying pipe. The alcohol precipitation tank and horizontal spiral centrifugal machine combined system is characterized in that the alcohol precipitation tank is detachably connected with the horizontal spiral centrifugal machine through the material conveying pipe; the position, close to the bottom of the alcohol precipitation tank, of the lower end of a stirring end is provided with a compressed gas spraying opening and is provide with a bottom stirring blade; meanwhile, the upper portion of the horizontal spiral centrifugal machine is provided with an inert gas input opening and a gas sampling opening; and the gas sampling opening is provided with an online gas oxygen detecting device. The alcohol precipitation tank and horizontal spiral centrifugal machine combined system is novel in design, reasonable in structure and convenient to operate, the traditional Chinese medicine extract producing rate can be increased by the adoption of the system, stability and controllability of preparation quality are facilitated, medicine liquid and ethyl alcohol in alcohol sediment are recycled through the improved horizontal spiral centrifugal machine, losses of solvents can be reduced, the resource utilization rate is increased, the production cost is reduced, the purpose of safe and efficient production is achieved, and a wide application and popularization prospect is achieved.

Description

technical field [0001] The invention relates to an alcohol precipitation tank and a decanter centrifuge combined system, which is suitable for the process of alcohol precipitation and impurity removal of traditional Chinese medicine extract, and belongs to the field of traditional Chinese medicine pharmaceutical equipment. Background technique [0002] The ethanol precipitation method (referred to as "alcohol precipitation") refers to the process in which the alcohol-insoluble components in the extracted medicinal liquid are precipitated and aggregated in ethanol solutions of different concentrations. It is soluble in water and ethanol but not active ingredients such as starch, protein, mucus, pigment and other impurities are soluble in water but insoluble in ethanol. The non-active components in the ethanol solution are removed by precipitation. Alcohol precipitation is a commonly used refining and purification method in the extraction process of traditional Chinese medici...

AI Technical Summary

Problems solved by technology

However, for precipitated particles with small specific gravity and low viscosity, such as Chaiyin Oral Liquid / Granules, Anshen Bunao Liquid, and Honeysuckle Water Extract from Lunan Houpu Pharmaceutical Co., Ltd., the insoluble matter precipitated by alcohol precipitation has a small specific gravity. , low viscosity, not easy to adsorb and aggregate each other, the sediment mainly falls to the bottom of the sedimentation tank by free sedimentation under the action of gravity, presenting a dispersed and suspended loose state, in which there are many wrapped and mixed medicinal liquids If the above-mentioned novel alcohol precipitation tank (publication number is CN203899215U) with inclined upward bottom stirring is used for alcohol precipitation operation, under the strong shear mixing power provided by the bottom stirring, the generated loose precipitate will be broken into finer loose Precipitation is not conducive to the static stratification of the supernatant and the sediment, the separation time of the liquid medicine and the sediment is long, the separation effect is poor, and the production is difficult

[0005] In addition, these loose precipitates contain as much as 40%-70% ethanol solution, and the filtration effect of conventional centrifugation, filter cloth, and filter paper is relatively poor and time-consuming, and the recovery rate of alcohol precipitation is low, which is not conducive to the production of later preparations

If the alcohol precipitation is discarded and the liquid medicine contained in the precipitation is not returned, it will cause the loss of effective substances and the waste of ethanol, pollute the environment, and is not conducive to energy saving and full utilization of resources.

Moreover, these deposits are not easy to transfer, inconvenient to operate, labor-intensive, more on-site dirt, easy to cause secondary pollution of the production environment, and do not meet the requirements of the current GMP for pharmaceutical production, etc.

[0006] Horizontal screw decanter centrifuge (hereinafter referred to as "decanter centrifuge") is a horizontal screw unloading, continuous operation sedimentation equipment, however, during the centrifugation process, the differential speed of the decanter centrifuge rotates in the same direction at high speed will produce Strong air flow vortex, the ethanol in the alcohol sediment will volatilize to produce ethanol vapor, and its vapor and air can form a mixture. When the concentration of ethanol vapor in the mixture is at the explosive limit of 3.3-19.0% (V / V), if at this time Friction between the drum and the fuselage will generate sparks or explosion may occur when encountering fire, which poses certain safety hazards

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