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Preparation of magnetic nano-drug carrier and method for using magnetic nano-drug carrier to load doxorubicin hydrochloride

A magnetic nano-drug technology, which is applied in the direction of medical formula, drug combination, drug delivery, etc., can solve the problems of poor therapeutic effect and high toxicity, and achieve the effects of low toxic and side effects, strong superparamagnetism, and easy preparation

Active Publication Date: 2018-01-09
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of the prior art, provide a method for preparing a magnetic nano drug carrier and its loading method of doxorubicin hydrochloride, and solve the technical problems of high toxicity and poor therapeutic effect in the prior art

Method used

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  • Preparation of magnetic nano-drug carrier and method for using magnetic nano-drug carrier to load doxorubicin hydrochloride
  • Preparation of magnetic nano-drug carrier and method for using magnetic nano-drug carrier to load doxorubicin hydrochloride
  • Preparation of magnetic nano-drug carrier and method for using magnetic nano-drug carrier to load doxorubicin hydrochloride

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Experimental program
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Effect test

Embodiment 1

[0041] A preparation method of a magnetic nano-medicine carrier in this embodiment comprises the following steps:

[0042] 1) Preparation of cyclodextrin-hyaluronic acid supramolecular polymer (β-CD-HA):

[0043] First, 18g of β-cyclodextrin (β-CD) and 11.06g of p-toluenesulfonyl chloride (TsCl) were slowly added to 120mL of pyridine solvent and stirred, and reacted at room temperature for 6h; the pyridine solvent was removed by rotary evaporation, and then recrystallized in water 1. Wash and purify with cold acetone to obtain the precipitate mono-6-deoxy-6-(p-toluenesulfonyl)-β-cyclodextrin (M-6-O-Ts-β-CD);

[0044] Then 5 g of mono-6-deoxy-6-(p-toluenesulfonyl)-β-cyclodextrin and 10.55 g of ethylenediamine (EDA) were dissolved in 25 mL of N-N-dimethylformamide (DMF), and the The reaction was carried out under magnetic stirring at 80°C for 18 hours in the environment. After the reaction was completed, the mixture was cooled to room temperature, then washed with cold acetone ...

Embodiment 2

[0056] A preparation method of a magnetic nano-medicine carrier in this embodiment comprises the following steps:

[0057] 1) Preparation of cyclodextrin-hyaluronic acid supramolecular polymer (β-CD-HA):

[0058] First, 17g of β-cyclodextrin (β-CD) and 11g of p-toluenesulfonyl chloride (TsCl) were slowly added into 100mL of pyridine solvent and stirred, and reacted at room temperature for 5h; the pyridine solvent was removed by rotary evaporation, and then recrystallized in water, Wash and purify with cold acetone to obtain the precipitate mono-6-deoxy-6-(p-toluenesulfonyl)-β-cyclodextrin (M-6-O-Ts-β-CD);

[0059] Then 4 g of mono-6-deoxy-6-(p-toluenesulfonyl)-β-cyclodextrin and 10 g of ethylenediamine (EDA) were dissolved in 20 mL of N-N-dimethylformamide (DMF), and the The reaction was carried out under magnetic stirring at 80°C for 18 hours in the environment. After the reaction was completed, the mixture was cooled to room temperature, then washed with cold acetone three ...

Embodiment 3

[0071] A preparation method of a magnetic nano-medicine carrier in this embodiment comprises the following steps:

[0072] 1) Preparation of cyclodextrin-hyaluronic acid supramolecular polymer (β-CD-HA):

[0073] First, 19g of β-cyclodextrin (β-CD) and 12g of p-toluenesulfonyl chloride (TsCl) were slowly added into 150mL of pyridine solvent and stirred, and reacted at room temperature for 8h; the pyridine solvent was removed by rotary evaporation, and then recrystallized in water, Wash and purify with cold acetone to obtain the precipitate mono-6-deoxy-6-(p-toluenesulfonyl)-β-cyclodextrin (M-6-O-Ts-β-CD);

[0074]Then 6 g of mono-6-deoxy-6-(p-toluenesulfonyl)-β-cyclodextrin (M-6-O-Ts-β-CD) and 12 g of ethylenediamine (EDA) were dissolved in 30 mL of N-N-di Methylformamide (DMF), and magnetically stirred at 80°C for 24 hours in a nitrogen atmosphere. After the reaction was completed, the mixture was cooled to room temperature, and then washed with cold acetone for 5 times to r...

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Abstract

The invention relates to the preparation of a magnetic nano-drug carrier and a method for using the magnetic nano-drug carrier to load doxorubicin hydrochloride, belonging to the technical field of magnetic nano-material drug transport. The invention mainly aims at solving the technical problems of high toxicity and poor treatment effect of the prior art. According to a technical scheme, a preparation method of the magnetic nano-drug carrier comprises the following steps: (1) preparing a cyclodextrin-hyaluronic acid supermolecule polymer; (2) preparing magnetic graphene oxide; (3) preparing the cyclodextrin-hyaluronic acid polymer-functionalized magnetic magnetic nano-drug carrier. Compared with the prior art, the magnetic nano-drug carrier is high in biocompatibility and low in toxicity,and has the characteristics of cancer cell targeted localization and drug controlled release, thus having an important application value in the aspect of biological drug carriers.

Description

technical field [0001] The invention belongs to the technical field of magnetic nanomaterial drug transport, and in particular relates to the preparation of a magnetic nano drug carrier and a method for loading doxorubicin hydrochloride. Background technique [0002] Traditional anticancer drugs have the disadvantages of systemic distribution and high cytotoxicity. Anthraquinones, as broad-spectrum anti-tumor drugs, embed drug molecules into DNA chains to block its replication to achieve the purpose of anti-tumor. Doxorubicin hydrochloride (DOX), as a new generation of anthraquinones, is less toxic than other anthraquinones and has a weaker cardioinhibitory effect, but it will have a certain impact on liver function. In order to achieve a safe and efficient therapeutic effect of DOX, it is particularly important to study drug carriers with targeted delivery functions to improve efficacy and safety. [0003] Graphene-based nanomaterials are simple to synthesize and have a l...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K47/04A61K47/36A61K47/69A61K9/00A61K41/00A61K31/704A61P35/00
Inventor 梁文婷戎艳琴芦冬涛马学文范丽芳董文娟董川双少敏
Owner SHANXI UNIV
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