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A kind of flocculent collagen hemostatic fiber and its preparation method

A technology of hemostatic fibers and collagen fibers, which can be used in surgery, surgical adhesives, medical science, etc., can solve the problems of poor mechanical properties and fast degradation of pure collagen fibers, and achieve reduced production costs, enhanced physical and chemical properties, and biodegradation The effect of simple performance and preparation process

Active Publication Date: 2020-06-26
BEIJING HOTWIRE MEDICAL TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure collagen fibers often have defects such as fast degradation speed and poor mechanical properties during the application process, which greatly limits its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Cut 100g of frozen Achilles tendon tissue into 1mm thick slices, wash and soak in purified water for 60 minutes. Drain the water, soak the slices in a phosphate buffer solution containing 0.3% ficin, the pH of the solution is 7.4, and let it stand at 8°C for 24 hours. Rinse and soak in purified water for 60 minutes, and drain the water. Soak slices in a solution containing 1.5M sodium hydroxide and 10% ammonium sulfate, and let stand at 8°C for 24 hours. The pH of the solution was adjusted to 5.0 with 5% sulfuric acid, rinsed and soaked in purified water for 60 minutes, and the collagen precipitate was collected by filtration to obtain a collagen sample.

Embodiment 2

[0030] Disperse 50 g of collagen samples evenly in 1% formaldehyde solution, soak at room temperature for 60 minutes, rinse and soak in purified water for 10 hours, and filter to remove water. Soak the collagen in 1000ml of 30% ethanol solution, let stand at room temperature for 30 minutes; add ethanol solution to make the volume fraction 50%, stir well and let stand for 30 minutes; then add ethanol solution to make the volume fraction 70% After stirring evenly, let it stand for 30 minutes; filter the collagen to remove the solution, place it in 1000ml of 90% ethanol solution, stir it evenly, let it stand for 30 minutes, then filter the collagen to remove the solution to obtain dehydrated collagen.

Embodiment 3

[0032] Disperse 50g of collagen sample evenly in 2% 1-ethyl-3(3-dimethylpropylamino)carbodiimide solution, soak for 120 minutes at room temperature, wash and soak in purified water for 12 hours, and filter to remove water. Soak the collagen in 800ml of 30% isopropanol solution, let stand at room temperature for 30 minutes; add isopropanol solution to make the volume fraction 50%, stir well and let stand for 30 minutes; then add isopropanol solution Make the volume fraction 70%, stir well and let it stand for 30 minutes; filter the collagen to remove the solution, place it in 800ml of 90% isopropanol solution, stir it and let it stand for 30 minutes, filter and remove the solution to obtain dehydration collagen.

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PUM

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Abstract

The invention discloses a collagen-based flocculent hemostatic material and a preparation method thereof. Hemostatic fiber is formed by two kinds of collagen particles in different particle sizes, andis characterized that a collagen fiber-based flocculent hemostatic material is finally obtained by carrying out technologies such as cross-linking modification, gradient dehydration, moderate smashing, vacuum drying and sterilizing on extracted and purified collagen fiber in sequence. The collagen-based flocculent hemostatic material disclosed by the invention uses the collagen fiber with a natural tissue structure, has excellent physical and chemical properties and excellent biological property such as hemostatic property, mechanical property, biodegradability and biocompatibility, can be well suitable for hemostasis and repairing of various irregular wounds, and can be widely applied to hemostasis and repairing of burns, wounds and surgical operation wounds.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of flocculent collagen hemostatic fibers. Background technique [0002] Biomedical materials are a high-tech new material developed in the past 30 years. Absorbable hemostatic materials have gradually attracted the attention of the medical community with the increase in traffic accidents, major disasters and other accidents. With the rapid development of modern science and technology, the research on hemostatic materials has made very fast progress, and various new hemostatic materials are constantly appearing, and their performance is getting better and better. Currently commonly used hemostatic materials include absorbable fibrin glue, chitosan, absorbable gelatin sponge, cyanoacrylate, oxidized cellulose, and oxidized regenerated cellulose. However, the above materials have certain defects, such as poor hemostatic effect, fast degradation rat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/00
Inventor 郑博富勇
Owner BEIJING HOTWIRE MEDICAL TECH DEV CO LTD