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Salicylic acid-doped silica nano-particle fluorescence sensor for iron ions, and production method and application thereof

A fluorescent sensor and silicon dioxide technology, applied in fluorescence/phosphorescence, material excitation analysis, etc., can solve the problems of expensive equipment, poor selectivity, and complicated operation, and achieve the effect of simple steps, mild method conditions, and easy steps

Active Publication Date: 2018-01-26
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Based on this, the purpose of the present invention is to overcome the detection of Fe in the prior art 3+ In order to improve the water solubility, photostability and biological toxicity of organic small molecule probes, a reusable salicylic acid-doped Silicon nanoparticles Fe 3+ The preparation method of the fluorescent sensor combines the fluorescent probe of small organic molecules with the inorganic matrix, which can greatly expand the application range of the fluorescent sensor

Method used

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  • Salicylic acid-doped silica nano-particle fluorescence sensor for iron ions, and production method and application thereof
  • Salicylic acid-doped silica nano-particle fluorescence sensor for iron ions, and production method and application thereof
  • Salicylic acid-doped silica nano-particle fluorescence sensor for iron ions, and production method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] In this example, salicylic acid-doped silica nanoparticles Fe 3+ The preparation method of fluorescent sensor is carried out according to the following steps:

[0037] (1) Add 100 mg of salicylic acid (SA) and 35 mL of absolute ethanol into a 50 mL round bottom flask, and stir for 20 min at room temperature under a nitrogen atmosphere;

[0038] (2) Then continue to add 310 μL of 3-aminopropyltriethoxysilane (APTES) and 1.4 mL of tetraethylorthosilicate (TEOS), and continue to stir for 30 minutes;

[0039] (3) Then add 120 μL of 25% NH 3 ·H 2 A mixed solution of O and 860 μL of water was passed through nitrogen for 30 minutes to remove oxygen, then the flask was sealed and stirred overnight for 24 hours;

[0040] (4) The product was collected by centrifugation, washed 5 times with 5 mL of absolute ethanol, and finally vacuum-dried at 50° C. for 12 h. The obtained white powder was salicylic acid-doped silica nanoparticles (SASP).

Embodiment 2

[0042]In this example, salicylic acid-doped silica nanoparticles Fe 3+ The preparation method of fluorescent sensor is carried out according to the following steps:

[0043] (1) Add 50 mg of salicylic acid (SA) and 35 mL of absolute ethanol into a 50 mL round bottom flask, and stir for 15 min at room temperature under a nitrogen atmosphere;

[0044] (2) Then continue to add 310 μL of 3-aminopropyltriethoxysilane (APTES) and 775 μL of tetraethylorthosilicate (TEOS), and continue to stir for 20 minutes;

[0045] (3) Then add 80 μL of 25% NH 3 ·H 2 O and 860 μL water mixed solution, through nitrogen gas for 45min to remove oxygen, then seal the flask and stir for 12h;

[0046] (4) The product was collected by centrifugation, washed 5 times with 5 mL of absolute ethanol, and finally dried in vacuum at 30° C. for 15 h, and the obtained white powder was salicylic acid-doped silica nanoparticles (SASP).

Embodiment 3

[0048] In this example, salicylic acid-doped silica nanoparticles Fe 3+ The preparation method of fluorescent sensor is carried out according to the following steps:

[0049] (1) Add 120mg of salicylic acid (SA) and 35mL of absolute ethanol into a 50mL round bottom flask, and stir for 45min at room temperature under a nitrogen atmosphere;

[0050] (2) Then continue to add 310 μL of 3-aminopropyltriethoxysilane (APTES) and 1.7 mL of tetraethylorthosilicate (TEOS), and continue to stir for 60 minutes;

[0051] (3) Then add 150 μL of 25% NH 3 ·H 2 O and 860 μL of water mixed solution, through nitrogen for 60min to remove oxygen, then seal the flask and stir for 30h;

[0052] (4) The product was collected by centrifugation, washed 5 times with 5 mL of absolute ethanol, and finally vacuum-dried at 55° C. for 8 h, and the obtained white powder was salicylic acid-doped silica nanoparticles (SASP).

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Abstract

The invention relates to a salicylic acid-doped silica nano-particle fluorescence sensor for Fe<3+>, and a production method and an application thereof. The production method comprises the following steps: (1) adding salicylic acid and anhydrous ethanol into a reaction container, and performing stirring at room temperature in a nitrogen atmosphere; (2) adding 3-aminopropyltriethoxysilane and tetraethyl orthosilicate, and continuously performing stirring; (3) adding an ammonia water and water mixed solution with the mass fraction being 25%, introducing nitrogen to ensure the complete removal ofoxygen, sealing the reaction container, and performing stirring; and (4) centrifuging the obtained material, collecting the obtained product, cleaning the product with anhydrous ethanol multiple times, and carrying out vacuum drying to obtain white powder which is salicylic acid-doped silica nano-particles. An organic small molecule fluorescence probe is combined with an inorganic matrix, so thewater solubility, the light stability and the biological toxicity of the organic small molecule probe are improved, and the probe can be recycled, thereby the application range of the fluorescence sensor is greatly enlarged.

Description

technical field [0001] The invention relates to the technical field of material preparation and detection, in particular to a salicylic acid-doped silicon dioxide nanoparticle Fe 3+ Preparation method of fluorescent sensor. Background technique [0002] Iron is a very important trace element in the human body. Hemoglobin in human blood is a complex of iron, which has the functions of fixing and transporting oxygen, and can also participate in many enzyme reactions. However, if the iron element is excessive or insufficient, it will be harmful to the human body and cause various physiological disorders. Therefore, it is very important to detect the iron content of organisms. [0003] Traditional methods for analyzing and detecting iron ions include electrochemical methods, spectrophotometry (UV), atomic absorption spectrometry (AAS), and inductively coupled plasma mass spectrometry (ICP-MS), which have poor selectivity, low sensitivity, and instrument cost. Expensive and c...

Claims

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Application Information

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IPC IPC(8): G01N21/64
Inventor 胡小刚刘忠勇刘炉英刘锦辉巫宝霞
Owner SOUTH CHINA NORMAL UNIVERSITY
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