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Antibacterial bone formation-promoting composite functional porous orthopaedic implant and preparation method thereof

A technology of orthopedic implants and composite functions, applied in the field of medical devices, can solve the problems of increasing the probability of bacterial infection, etc., and achieve the effects of excellent bactericidal performance, long-lasting killing ability, and strong drug-loading ability

Active Publication Date: 2018-02-06
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that metal implants in the prior art have the problem of promoting osseointegration and increasing the probability of bacterial infection, the present invention provides a porous orthopedic implant that can promote osseointegration and has excellent antibacterial effect and its preparation method

Method used

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  • Antibacterial bone formation-promoting composite functional porous orthopaedic implant and preparation method thereof
  • Antibacterial bone formation-promoting composite functional porous orthopaedic implant and preparation method thereof
  • Antibacterial bone formation-promoting composite functional porous orthopaedic implant and preparation method thereof

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preparation example Construction

[0044] The preparation method provided by the invention comprises the following steps:

[0045] In order to solve the above-mentioned technical problems, the present invention provides a method for preparing a porous orthopedic implant with antibacterial and osseointegration-promoting functions, comprising the following steps:

[0046] (1) Using 3D printing technology to make porous orthopedic implants;

[0047] (2) performing surface treatment on the porous orthopedic implant by micro-arc oxidation method, covering the surface of the porous orthopedic implant with a micro-arc oxidation coating containing calcium and phosphorus elements;

[0048] (3) Immerse the porous orthopedic implant treated in step (2) in a 2-5 mg / mL dopamine hydrochloride solution, and vibrate at a constant temperature of 30-45° C. for 20-24 hours;

[0049] (4) Use deionized water or distilled water as a solvent, add heparin sodium to dissolve, and prepare a heparin sodium solution with a concentration ...

Embodiment 1

[0077] (1) Porous orthopedic implants with interconnected pores were fabricated using 3D printing technology.

[0078] Individually adapted porous Ti-6Al-4V implants were printed using the EBM S12 electron beam melting equipment produced by the Swedish ARCAM company, with a pore diameter of 640 μm, a pillar diameter of 400 μm, and a diamond lattice pore structure.

[0079] (2) Utilize micro-arc oxidation method to carry out surface treatment to described porous Ti-6Al-4V implant, be covered with the micro-arc oxidation coating of 2.1 μm on the outer surface of this implant, the inner surface is covered with 1.1 μm Micro-arc oxidation coating.

[0080](21) Use deionized water to prepare an alkaline electrolyte containing calcium acetate 0.065mol / L, sodium dihydrogen phosphate 0.03mol / L, EDTA-2Na0.04mol / L, and sodium hydroxide 0.5mol / L;

[0081] (22) With the porous Ti-6Al-4V implant prepared in step (1) as the anode and the stainless steel as the cathode, a magnetic stirrer is...

Embodiment 2

[0111] (1) The EBM S12 electron beam melting equipment was used to print individualized porous titanium implants with a pore diameter of 600 μm, a pillar diameter of 500 μm, and a dodecahedral pore structure.

[0112] (2) The porous titanium implant is surface treated by micro-arc oxidation method. The outer surface of the implant is covered with a 1.5 μm micro-arc oxidation coating, and the inner surface is covered with a 0.8 μm micro-arc oxidation coating. layer.

[0113] (21) Use deionized water or prepare an alkaline electrolyte containing 0.01mol / L calcium acetate, 0.01mol / L sodium dihydrogen phosphate, 0.02mol / L EDTA-2Na, and 0.25mol / L sodium hydroxide;

[0114] (22) The porous titanium implant prepared in step (1) was used as the anode, and the stainless steel was used as the cathode, and the alkaline electrolyte was stirred with a magnetic stirrer at a stirring speed of 60 times / min; a DC pulse power supply was used for micro-arc oxidation. Set the voltage to 250V, th...

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Abstract

The invention relates to an antibacterial bone formation-promoting composite functional porous orthopaedic implant and a preparation method. The preparation method comprises the following steps: (1) preparing a porous orthopaedic implant by utilizing a 3D printing technology; (2) carrying out surface treatment on the porous orthopaedic implant by utilizing a micro-arc oxidation method, and covering the surface of the porous orthopaedic implant with a micro-arc oxidation coating containing calcium and phosphorus elements; (3) soaking the implant treated by the step (2) into 2-5mg / mL dopamine hydrochloride solution, and vibrating for 20-24 hours at the constant temperature of 30-45 DEG C; and (4) by taking deionized water or distilled water as a solvent, adding heparin sodium and preparing aheparin sodium solution with the concentration of 1-5mg / mL, then by taking the heparin sodium solution as a solvent, adding gentamicin and preparing a gentamicin solution with the concentration of 1-5mg / mL; and soaking the implant treated by the step (3) into the gentamicin solution, and vibrating for 4-10 hours at the constant temperature of 30-45 DEG C, so that the implant is obtained.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an antibacterial and bone-promoting composite functional porous orthopedic implant and a preparation method thereof. Background technique [0002] Metal implants are widely used clinically, but metal implants exhibit obvious biological inertia. At present, the use of surface modification technology to improve the surface activity of metal implants is an effective way to further improve their application effects. [0003] Currently, the prior art discloses a method for preparing a calcium-phosphorous coating on the porous surface of a metal implant, which can improve its osseointegration performance. However, the surface of biomaterials that can promote bone cell adhesion and growth is also suitable for bacterial colonization, especially 3D printed porous metal orthopedic implants, although they have the characteristics of strong osseointegration and can be individually adapted to ...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/14A61L31/10A61L31/02C25D11/26C25D11/30
CPCA61L31/022A61L31/10A61L31/146A61L31/16A61L2300/23A61L2300/404A61L2300/602C25D11/026C25D11/26C25D11/30C08L79/02C08L5/10
Inventor 张腾刘忠军
Owner PEKING UNIV THIRD HOSPITAL
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