Preparation method of carboxymethylcellulose porous hemostatic microspheres

A technology of carboxymethyl cellulose and cellulose, which is applied in the field of preparation of carboxymethyl cellulose porous hemostatic microspheres, can solve the problems of long preparation time, high cost, environmental pollution, etc., and achieve fast preparation speed and uniform particle size controllable effect

Inactive Publication Date: 2018-02-09
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These preparation methods mostly use organic solvents, which are easy to cause pollution to the environment; and some preparation methods are complicated in process and long in preparation time, resulting in high cost

Method used

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  • Preparation method of carboxymethylcellulose porous hemostatic microspheres
  • Preparation method of carboxymethylcellulose porous hemostatic microspheres
  • Preparation method of carboxymethylcellulose porous hemostatic microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Preparation of 3.85% cellulose solution: Dissolve 7g of lithium hydroxide and 12g of urea in 81g of water, then add 4g of cellulose into the solvent, and stir at room temperature for 15min. Put the mixed solution in a low-temperature refrigerator to freeze at -30°C, take it out and thaw while stirring, and then refrigerate at 4°C for 1 day. Then take it out and stir evenly, then filter it with a 400-mesh filter cloth, and let the filtrate stand at 4°C for 3 hours.

[0028] 2. Preparation of carboxymethyl cellulose solution: add 0.2 g of sodium chloroacetate to 25 g of 4% cellulose solution, and stir magnetically at 8° C. for 24 hours. The carboxymethyl substitution degree of carboxymethyl cellulose is 0.07.

[0029] 3. Prepare coagulation solution: Dissolve 20mL sulfuric acid in 230mL aqueous solution as coagulation solution.

[0030] 4. Preparation of microspheres: inject 25 g of carboxymethyl cellulose solution into a 20 mL syringe, and obtain carboxymethyl cellu...

Embodiment 2

[0034] 1. Preparation of 3.85% cellulose solution: Dissolve 7g of lithium hydroxide and 12g of urea in 81g of water, then add 4g of cellulose into the solvent, and stir at room temperature for 15min. Put the mixed solution in a low-temperature refrigerator to freeze at -30°C, take it out and thaw while stirring, and then refrigerate at 4°C for 1 day. Then take it out and stir evenly, then filter it with a 400-mesh filter cloth, and let the filtrate stand at 4°C for 3 hours.

[0035] 2. Preparation of carboxymethyl cellulose solution: add 1 g of sodium chloroacetate to 25 g of 4% cellulose solution, and stir magnetically at 8°C for 24 hours. The carboxymethyl substitution degree of carboxymethyl cellulose is 0.13.

[0036] 3. Prepare coagulation solution: Dissolve 20mL sulfuric acid in 230mL aqueous solution as coagulation solution.

[0037] 4. Preparation of microspheres: inject 25 g of carboxymethyl cellulose solution into a 20 mL syringe, and obtain carboxymethyl cellulose...

Embodiment 3

[0040] 1. Preparation of 3.85% cellulose solution: Dissolve 7g of lithium hydroxide and 12g of urea in 81g of water, then add 4g of cellulose into the solvent, and stir at room temperature for 15min. Put the mixed solution in a low-temperature refrigerator to freeze at -30°C, take it out and thaw while stirring, and then refrigerate at 4°C for 1 day. Then take it out and stir evenly, then filter it with a 400-mesh filter cloth, and let the filtrate stand at 4°C for 3 hours.

[0041] 2. Preparation of carboxymethyl cellulose solution: add 0.1 g of sodium chloroacetate to 25 g of 4% cellulose solution, and stir magnetically at 8° C. for 24 hours. The carboxymethyl substitution degree of carboxymethyl cellulose is 0.02.

[0042] 3. Prepare coagulation solution: Dissolve 20mL sulfuric acid in 230mL aqueous solution as coagulation solution.

[0043] 4. Preparation of microspheres: inject 25 g of carboxymethyl cellulose solution into a 20 mL syringe, and obtain carboxymethyl cellu...

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Abstract

The invention provides a preparation method of carboxymethylcellulose porous hemostatic microspheres. The preparation method comprises the following steps: adding sodium chloroacetate into a celluloseaqueous solution and reacting at 8 DEG C to obtain a carboxymethylcellulose aqueous solution; and spraying the reaction liquid into solidification liquid by an electrostatic spraying method, regenerating and molding, washing and performing supercritical carbon dioxide drying to obtain the carboxymethylcellulose porous hemostatic microspheres, wherein the carboxymethylcellulose aqueous solution contains cellulose, urea and lithium hydroxide. The preparation method has the following beneficial effects: 1. the reaction liquid is directly subjected to electrostatic spraying, the preparation speedis high, environmental friendliness is achieved, and the particle size is uniform and controllable; and 2. the carboxymethylcellulose microspheres have porous structure characteristic, the porosity is 30 to 60 percent, the water-absorbing rate is up to 300 to 600 percent and the specific surface area is 100 to 250 m<2> / g. The carboxymethylcellulose porous hemostatic microspheres provided by the invention can serve as rapid hemostatic for hemorrhagic traumatic wound.

Description

technical field [0001] The invention relates to a preparation method of carboxymethylcellulose porous hemostatic microspheres, belonging to the technical field of natural polymer materials. Background technique [0002] Cellulose is the most abundant natural polymer on earth. Like cellulose, its derivative carboxymethyl cellulose has good biodegradation and biocompatibility, and is widely used in food, medicine, daily chemical, printing and dyeing, petrochemical and other industrial fields, such as hemostatic gauze, Emulsion stabilizer, drug coating and release, precipitant and filter membrane, etc. [0003] There have been many reports of cellulose products as hemostatic materials. For example, Zhang Zhiguo et al. invented a preparation method of a new type of oxidized cellulose hemostatic product (notification number: CN105561379A); Huang Yudong et al. invented a kind of oxidized regenerated cellulose hemostatic material with surface nanostructure (notification number: C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J3/12C08B11/12A61L24/00A61L24/08
CPCA61L24/001A61L24/0015A61L24/0036A61L24/08A61L2300/418A61L2400/04C08B11/12C08J3/122C08J9/28C08J2201/0504C08J2207/10C08J2301/28C08L1/286
Inventor 刘海清吴伟鑫
Owner FUJIAN NORMAL UNIV
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