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Medical phosphorus-32 carbon microspheres and preparation method thereof

A technology of carbon microspheres and preparations, which is applied in the field of medical phosphorus-32 carbon microspheres and its preparation, can solve the problems of glass microsphere restrictions and influence on popularization and application, and achieve low production cost, easy promotion and application, and less impurities Effect

Active Publication Date: 2020-02-28
CHENGDU NEW RADIOMEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Phosphorus-32 ( 32 P) is the most commonly used therapeutic nuclide in nuclear medicine, phosphorus-32 ( 32 P) Glass microspheres have been developed in China for many years, and many clinical studies have been reported [Zheng Guangyong, Wang Dazhang. A new anti-cancer therapy-radioactive glass microspheres perfusion intraarterial irradiation therapy. Journal of Oral and Maxillofacial Surgery 1991; 1 (1): 52-55] [Wang Dazhang, Sun Wenhao, et al. Experimental and clinical application research on the anticancer effect of phosphorus-32 glass microspheres perfused in the region. West China Journal of Stomatology 1991; 9 (1): 7- 10] [Wang Dazhang, Li Maoliang, et al. Preliminary application evaluation of arterial infusion of phosphorus-32 glass microspheres in the treatment of oral cancer. West China Journal of Stomatology 1991; 9 (2): 138-141], the curative effect on liver cancer and other tumors is remarkable, It has received great attention from the international medical community, but timely production of phosphorus-32 with high specific activity ( 32 P) Glass microspheres are restricted, which affects the promotion and application

Method used

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Embodiment

[0038] (1) Purification of carbon microspheres: Soak in organic solvents such as ethyl acetate, acetone or ethanol to remove fat; soak in dilute sodium hydroxide solution (0.1-0.5mol / L) to remove alkali-soluble impurities, and then repeatedly wash to weak alkali (PH value of 8-10); then soak in dilute nitric acid (0.1mol / L-0.5mol / L) to remove acid-soluble impurities, and wash until the pH value is 1-2.

[0039] (2) Preparation of sodium phosphate (Na 3 32 PO 4 ) solution: commercially available superior pure 30g magnesium hydrogen phosphate (MgHPO 4 ) or aluminum phosphate (AlPO 4 ) sealed in a quartz glass tube placed in a thermal neutron flux higher than 5×10 13 n / cm 2 .s nuclear reactor irradiation, after 31 P(n,r) 32 P generates radioactive magnesium hydrogen phosphate (MgH 32 PO 4 ) or radioactive aluminum phosphate (Al 32 PO 4 ), 32 The nuclear purity of P is not less than 99.9%, and the specific activity is greater than 148G Bq(4Ci) / gP. diluted] dissolved, ...

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Abstract

A medical phosphorus-32 carbon microsphere for use in cancer treatment and a preparation method therefor. The medical phosphorus-32 carbon microsphere is prepared as follows: using carbon microspheres to absorb an yttrium tartrate complex generated from a reaction between YCl3 and a tartaric acid solution, and then treating by using a solution of Na3 32PO4 to generate Y32Po4, next performing precipitation curing and purification, and thus obtaining the microsphere.

Description

technical field [0001] The invention relates to a tumor radiotherapy drug and a preparation method thereof, in particular to a medical phosphorus-32 carbon microsphere and a preparation method thereof. Background technique [0002] Radiation therapy is an important method of tumor treatment. Although various tumors have different sensitivities to radiation therapy, they are all sensitive to radiation therapy at therapeutic doses. The current forms of radiotherapy include external radiation therapy for tumors, interstitial implantation therapy, and radioembolization therapy. Taking liver cancer as an example, since the radiation tolerance of liver tissue is about 30Gy, which is far lower than the therapeutic dose of liver cancer (at least 60Gy), conventional external radiation therapy is not suitable for the treatment of liver cancer because it is easy to cause radiation hepatitis [Cheng Baoxing, Wu Haorong, Wu Jinchang. Experimental study on the treatment of metastatic live...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/12A61K51/02A61K51/00A61P35/00A61K101/00
CPCA61K51/00A61K51/02A61K51/1251A61K51/12A61P35/00
Inventor 李茂良蔡继鸣胡学正葛强
Owner CHENGDU NEW RADIOMEDICINE TECH CO LTD