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Medical yttrium-90 carbon microspheres and preparation method thereof

A technology of carbon microspheres and 90Y-EDTA, which is applied in powder delivery, antineoplastic drugs, radioactive carriers, etc., can solve the problems of curative effect limitation and repeated use, and achieve good safety, high utilization rate and low production cost Effect

Active Publication Date: 2020-02-28
CHENGDU NEW RADIOMEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are yttrium-90 glass microspheres and cationic resin microspheres used for the treatment of liver cancer and the monoclonal antibody drug Zevalin ( 90 Y-mouse antibody), Zevalin ( 90 Y-mouse antibody) is an anti-CD20 monoclonal antibody drug that has been marketed in the United States, but because it is a mouse antibody treatment drug, a HAMA reaction will occur during use, and it cannot be used repeatedly, and its curative effect is limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0036] (1) Purification of carbon microspheres: Soak in organic solvents such as ethyl acetate, acetone or ethanol to remove fat; soak in dilute sodium hydroxide solution (0.1-0.5mol / L) to remove alkali-soluble impurities, and then repeatedly wash to weak alkali (pH value is 8-10); then soak in dilute nitric acid (0.1mol / L-0.5mol / L) to remove acid-soluble impurities, and wash until the pH value is 1-2.

[0037] (2) The commercially available premium pure 25g Y 2 o 3 Sealed in a quartz glass tube and placed in a thermal neutron flux higher than 5×10 13 n / cm 2 .s nuclear reactor irradiation, after 89 Y(n,r) 90 Y reaction generation 90 Y 2 o 3 , the specific activity is greater than 370G Bq(10Ci) / gY, 90 The nuclear purity of Y is not less than 99.9%, and then dissolve it with 300mL of HCl solution [where hydrochloric acid is diluted with 36-38% HCl solution and water at a ratio of 1:1 (mL / mL)]. After cooling to room temperature, transfer to a 500mL volumetric flask and d...

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Abstract

A medical yttrium-90 (90Y) carbon microsphere used for the treatment of tumours, and a preparation method therefor. The medical yttrium-90 series of carbon microspheres uses a series of carbon microspheres to adsorb a 90YCl3 solution and ethylene diamine tetraacetic acid disodium salt solution generated complex (90Y-EDTA) to prepare medical yttrium-90 series carbon microspheres.

Description

technical field [0001] The invention relates to a tumor radiotherapy drug and a preparation method thereof, in particular to a medical yttrium-90 carbon microsphere and a preparation method thereof. Background technique [0002] Internal radiation therapy (also known as interventional radiation therapy) is a method developed in recent years to treat malignant tumors. Internal radiation therapy using different radionuclides in various ways has been continuously applied to animal experiments and clinical trials, and has achieved great results. good curative effect. Radioactive microspheres for interventional therapy of tumors, because of the dual effects of internal radiation and vascular embolism, the therapeutic effect is more prominent than other embolization methods. The new type of radioactive microspheres with stable physical and chemical properties and high efficiency ( 90 Y glass microspheres and 90 Y resin microspheres) have been used to treat patients with liver ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/12A61K51/02A61P35/00A61K103/32
CPCA61K51/02A61K51/1251A61K51/12A61P35/00
Inventor 李茂良蔡继鸣胡学正葛强
Owner CHENGDU NEW RADIOMEDICINE TECH CO LTD