Three-dimensional sleeve material for nerve repair

A technology of nerve repair and cannula, which is applied in the field of scaffold materials with putamen structure, can solve the problems of huge difference in release curve, poor material strength, and limited use, and achieve good biocompatibility, compact multi-layer structure, and avoid inflammation. The effect of sexual response

Inactive Publication Date: 2018-03-13
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The nerve cannula is designed with FDA-approved absorbable polymers. Although biocompatibility and in vivo degradability have been proven, the strength of the material is relatively poor, and the strength and shape are not easy to maintain for a long time after implantation. Part of the casing is prone to displacement, unexpected fracture and collapse due to insufficient support, which greatly limits its use
In addition, in order to better promote nerve repair, many research teams have also tried to load active substances such as viscous proteins and growth factors into the cannula, but due to the huge differences in release curves and different organisms, it is impossible to truly clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A three-dimensional casing material for nerve repair, characterized in that: the preparation method of the three-dimensional casing material follows the steps:

[0030] s1, polycaprolactone and polyglycolide lactide copolymer are dissolved in the mixed solvent of DMF and chloroform respectively, obtain polycaprolactone solution and polyglycolide lactide copolymer solution;

[0031] s2, dissolving the gelatin in a mixed solvent of DMF and water to obtain a gelatin solution;

[0032] s3, adding the gelatin solution, polycaprolactone solution and poly-sc-lactide copolymer solution to a coaxial electrospinning machine for electrospinning to obtain a nonwoven fabric;

[0033] s4, take the polypropylene monofilament as the shaft, curl the non-woven fabric into the shape of a sleeve, and soak it in the ethanol aqueous solution for 10 minutes;

[0034] s5, remove the sleeve and perform low-temperature vacuum drying and sterilization to obtain the three-dimensional sleeve mater...

Embodiment 2

[0045] A three-dimensional casing material for nerve repair, characterized in that: the preparation method of the three-dimensional casing material follows the steps:

[0046]s1, polycaprolactone and polyglycolide lactide copolymer are dissolved in the mixed solvent of DMF and chloroform respectively, obtain polycaprolactone solution and polyglycolide lactide copolymer solution;

[0047] s2, dissolving the gelatin in a mixed solvent of DMF and water to obtain a gelatin solution;

[0048] s3, adding the gelatin solution, polycaprolactone solution and poly-sc-lactide copolymer solution to a coaxial electrospinning machine for electrospinning to obtain a nonwoven fabric;

[0049] s4, take the polypropylene monofilament as the shaft, curl the non-woven fabric into the shape of a sleeve, and soak it in the ethanol aqueous solution for 10 minutes;

[0050] s5, remove the sleeve and perform low-temperature vacuum drying and sterilization to obtain the three-dimensional sleeve materi...

Embodiment 3

[0061] A three-dimensional casing material for nerve repair, characterized in that: the preparation method of the three-dimensional casing material follows the steps:

[0062] s1, polycaprolactone and polyglycolide lactide copolymer are dissolved in the mixed solvent of DMF and chloroform respectively, obtain polycaprolactone solution and polyglycolide lactide copolymer solution;

[0063] s2, dissolving the gelatin in a mixed solvent of DMF and water to obtain a gelatin solution;

[0064] s3, adding the gelatin solution, polycaprolactone solution and poly-sc-lactide copolymer solution to a coaxial electrospinning machine for electrospinning to obtain a nonwoven fabric;

[0065] s4, take the polypropylene monofilament as the shaft, curl the non-woven fabric into the shape of a sleeve, and soak it in the ethanol aqueous solution for 10 minutes;

[0066] s5, remove the sleeve and perform low-temperature vacuum drying and sterilization to obtain the three-dimensional sleeve mater...

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Abstract

The invention discloses a tissue engineering scaffold material for nerve repair and a preparation method thereof. Gelatin protein is taken as a shell structure of a fiber by utilizing a preparation mode of coaxial high-voltage electrostatic spinning, a polycaprolactone and poly(d,l-lactide-co-glycolide) copolymer is taken as an inner core structure, and a single fiber membrane is spun first; and then, the fiber membrane is coiled into a sleeve shape by taking a polyethylene mono-filament as an axis, so that the fiber membrane can be used as a nerve sleeve. The three-dimensional sleeve materialprepared by the method provided by the invention is implanted into a human body, has good biocompatibility with blood, tissue fluid and body fluid, has a stable structure and is not easy to collapse.

Description

technical field [0001] The present invention relates to a tissue engineering scaffold material for nerve repair and its preparation method, more specifically, a scaffold material with a putamen structure prepared by coaxial electrospinning, which is multi-layered and curled into a sleeve shape for nerve repair . Background technique [0002] At present, high-voltage electrospinning, as a popular manufacturing technology for the preparation of two-dimensional fiber materials, has attracted much attention because the prepared fibers have an extracellular matrix-like structure. Coaxial high-voltage electrospinning is a special form of this technical field. It can prepare a variety of shell-core structure fibers and mix various types of materials through non-solution mixing methods to achieve microscopic adjustment of the physical properties of fiber materials. combination. Especially for hydrophilic and hydrophobic polymers, it is difficult to find a co-solvent to dissolve di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/18A61L27/22D04H1/728D01D5/00
CPCA61L27/18A61L27/222A61L27/50A61L2430/32D01D5/0015D04H1/728C08L67/04
Inventor 孟庆怡许杉杉赵亮亮黄健翔
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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