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A wound dressing composite nanofibrous film and its preparation method

A technology of composite nanofibers and nanofiber membranes, applied in fiber treatment, pharmaceutical formulations, bandages, etc., can solve problems such as wound re-infection, and achieve the effects of low antigenicity, stability, and good air permeability

Active Publication Date: 2020-11-24
GUANGZHOU MUNICIPAL ZHONGWEI BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a method for preparing wound dressing nanofiber membranes with coaxial electrospinning technology for existing dressings that easily cause wound reinfection and bring unbearable pain to patients.

Method used

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  • A wound dressing composite nanofibrous film and its preparation method
  • A wound dressing composite nanofibrous film and its preparation method
  • A wound dressing composite nanofibrous film and its preparation method

Examples

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Embodiment 1

[0030] A wound dressing composite nanofibrous membrane, the preparation raw materials include polyvinylidene fluoride, pH responsive polymer, collagen;

[0031] The preparation method of this composite nanofiber membrane comprises the following steps:

[0032] 1) Preparation of the shell solution: adding the polyvinylidene fluoride: PH-responsive polymer PMMA mass ratio to 1:0.5 into hexafluoroisopropanol, stirring evenly, and preparing the mass volume ratio concentration of 8 % shell solution;

[0033] 2) Preparation of nuclear layer solution: dissolving collagen in hexafluoroisopropanol to prepare a solution with a mass-volume concentration of 10%, then adding drugs and growth factors, and stirring evenly to prepare a nuclear layer solution;

[0034] 3) Inject the shell solution in step 1) and the core layer solution in step 2) into the outer needle and the inner needle of the coaxial electrospinning needle respectively, wherein the inner diameter of the outer needle is 0.8...

Embodiment 2

[0036] The preparation method of this composite nanofiber membrane comprises the following steps:

[0037] 1) Preparation of the shell solution: add the polyvinylidene fluoride: PH responsive polymer PMMA mass ratio to 1:1 in hexafluoroisopropanol, stir evenly, and prepare the mass volume ratio concentration of 12 % shell solution;

[0038] 2) Preparation of nuclear layer solution: dissolving collagen in hexafluoroisopropanol to prepare a solution with a concentration of 12% by mass to volume, then adding drugs, growth factors, and proteins, and stirring evenly to prepare a nuclear layer solution;

[0039] 3) Inject the shell solution in step 1) and the core layer solution in step 2) into the outer needle and the inner needle of the coaxial electrospinning needle respectively, wherein the inner diameter of the outer needle is 1.0 mm, and the inner diameter of the inner needle is 0.4 mm, the electrospinning takes the accepting distance as 15cm, the liquid feeding speed of the ...

Embodiment 3

[0041] The preparation method of the composite nanofiber membrane of the present embodiment comprises the following steps:

[0042] 1) Preparation of the shell solution: add the polyvinylidene fluoride: PH responsive polymer PMMA mass ratio to 1:2 in hexafluoroisopropanol, stir evenly, and prepare the mass volume ratio concentration of 16 % shell solution;

[0043]2) Preparation of nuclear layer solution: dissolving collagen in hexafluoroisopropanol to prepare a solution with a mass-volume concentration of 15%, then adding drugs, growth factors, and proteins, and stirring evenly to prepare a nuclear layer solution;

[0044] 3) Inject the shell solution in step 1) and the core layer solution in step 2) into the outer needle and the inner needle of the coaxial electrospinning needle respectively, wherein the inner diameter of the outer needle is 0.9 mm, and the inner diameter of the inner needle is 0.5 mm. mm, the electrospinning takes the receiving distance as 18cm, the liquid...

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Abstract

The invention discloses wound dressing composite nano fiber membrane, prepared from polyvinylidene fluoride, a pH-responding macromolecular polymer and collagen. A preparation method of the wound dressing composite nano fiber membrane comprises the steps of 1) preparing a shell solution, to be specific, adding polyvinylidene fluoride and the pH-responding macromolecular polymer into hexafluoroisopropanol, stirring well to obtain the shell solution; 2) preparing a core solution, to be specific, dissolving collagen in hexafluoroisopropanol, adding drugs, and stirring well to obtain the core solution; 3) injecting the shell solution of step 1) and the core solution of step 2) respectively into an outer needle, having diameter of 0.8-1.2 mm, and inner needle, having diameter of 0.2-1 mm of a coaxial electrostatic spinning needle, and under the voltage of 13-21 kv, receipt distance of 10-30 cm, inner liquid feeding speed of 0.1-0.5 ml / min and outer liquid feeding speed of 0.8-2 ml / min, andconnecting an electrostatic generator to the coaxial electrostatic spinning needle to perform electrostatic spinning so that porous core-shell nano fiber dressing is obtained.

Description

technical field [0001] The invention relates to the technical field of medical wound dressings, in particular to a composite nanofiber membrane and a preparation method thereof. Background technique [0002] Medical dressings are an important medical material used to cover wounds. They can replace damaged skin to act as a temporary barrier, avoid or control wound infection, and provide an environment conducive to wound healing. The development of science and technology has made people's requirements for medical dressings continue to increase. Traditional dressings are mainly used for isolation and antibacterial effects on wounds, but the effect of preventing re-infection is not ideal. [0003] The nanofiber membrane prepared by electrospinning technology has high porosity and good air permeability, which can keep the wound moist and is conducive to the respiration of cells. In the process of electrospinning, the drug ingredients are added to the spinning solution, and nanof...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/32A61L15/42D01D5/00
CPCA61L15/225A61L15/42A61L15/425A61L2400/12D01D5/0015C08L27/16C08L33/02C08L89/00
Inventor 赵月张俊辉万华印曾翠丽朱晋辉
Owner GUANGZHOU MUNICIPAL ZHONGWEI BIOTECH CO LTD
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