Method used for producing imitated coral artificial bone from cuttlebone, and products of method

A technology for artificial bone and sea octopus, which is applied in the field of increasing material manufacturing, can solve problems such as porosity and pore size that cannot be effectively controlled, cell adhesion, influence on metabolic growth and reproduction, scarcity of raw materials, etc., to achieve precise control of mechanical properties, material The effect of high utilization and rich sources

Inactive Publication Date: 2018-03-23
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above defects or improvement needs of the prior art, the present invention provides a method for preparing imitation coral artificial bone with sea octopus and its products, by selecting sea octopus as raw material, and through additive manufacturing and hydrothermal reaction method, the purpose of which is to obtain a new type of coral-like bone repair material with a coral-like microporous structure, a degradation rate that matches the growth rate of new bone, and a high osteoinductive activity, so as to replace the scarce natural coral resources, thereby solving the problem of artificial bone scaffolds. Raw materials are scarce in the preparation of artificial bone scaffolds, and the mechanical strength, porosity and pore size of artificial bone scaffolds cannot be effectively controlled, and the technical problems of cell adhesion, metabolism, growth and reproduction are affected

Method used

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  • Method used for producing imitated coral artificial bone from cuttlebone, and products of method
  • Method used for producing imitated coral artificial bone from cuttlebone, and products of method
  • Method used for producing imitated coral artificial bone from cuttlebone, and products of method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) select sea octopus powder and poly-L-lactic acid (PLLA) powder with a particle size range of 20 to 70um, and the particle size of PLLA powder as a binder is smaller than that of the sea octopus powder, wherein the binding agent The mass fraction is 10%.

[0043] (2) the sea octopus powder and PLLA powder (mass content is 15%) selected in step (1) adopt ball mill to carry out mechanical mixing to these two kinds of powders, carry out mechanical mixing to these two kinds of powders with ball mill, two The ingredients are mixed well. The specific steps of mechanical mixing are as follows:

[0044] Clean the table of the ball mill to ensure that the table is clean and tidy;

[0045] Before operation, check whether the frame, reducer, and bearing seat are installed properly, and tighten each mounting screw;

[0046] After installing the inner and outer barrels, rotate them for a few minutes without load to see if the equipment is operating normally;

[0047] After th...

Embodiment 2

[0056] (1) Select sea octopus powder and polyether ether ketone (PEEK) powder with a particle size range of 20 μm to 70 um, and the particle size of PEEK powder used as a binder is smaller than that of sea octopus powder, and the quality of the binder The score is 40%.

[0057] (2) As in Example 1, the sea octopus / PEEK composite powder material was prepared by mechanical mixing method, and the specific preparation steps were similar to Example 1.

[0058] (3) Design the structure of imitation coral artificial bone. Natural coral has a completely through pore structure with a porosity of 60% and a bending strength of 0.25MPa. The structure designed in this embodiment is as Figure 4 shown.

[0059] (4) Convert the three-dimensional model of the artificial bone structure designed in step (3) into STL format, and import it into the SLS device, so that the uniformly mixed composite powder in step (2) is formed into the structure designed in step (3), Get the initial shape of t...

Embodiment 3

[0062] (1) Preparation of sea octopus / PLLA composite filamentary material for FDM process. Concrete preparation steps are as follows:

[0063] The sea octopus and PLLA were vacuum-dried at 70°C and 150°C for 24 hours, respectively, and then the dried sea octopus and PLLA were mixed according to the mass ratio of 6:1.

[0064] In order to make the raw materials uniform during the melt blending process, pre-mix the prepared materials with a high-speed mixer that has been fully cleaned and dried in advance, then start the high-speed mixer at a low speed, and then proceed at a speed of 100r / min. Stir, the stirring time can be set to 10-15min.

[0065] Put the preliminarily obtained mixed material into the twin-screw extruder, melt and mix at the screw speed of 100r / min, and the cylinder temperature of 210°C. The air dryer completes the preliminary drying.

[0066] The blended material was prepared by pelletizing with an automatic pelletizer.

[0067] The prepared pellets are e...

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Abstract

The invention belongs to the field of additive manufacturing, and discloses a method used for producing imitated coral artificial bone from cuttlebone, and obtained products. The method comprises following steps: a, cuttlebone powder and an adhesive are taken as raw materials, and are mixed so as to obtain a composite material used for additive manufacturing; b, a three dimensional model of the imitated coral artificial bone to be produced is designed, and additive manufacturing is carried out with the composite material obtained in step a based on the three dimensional model so as to obtain aprimary product; c, a diammonium hydrogen phosphate solution is prepared, the primary product is immersed in the diammonium hydrogen phosphate solution for hydrothermal reaction so as to obtain hydroxyapatite and finish production of the imitated coral artificial bone. The imitated coral artificial bone is excellent in artificial bone mechanical properties, and appropriate in degradation rate; the raw materials are widely available, renewable, and low in cost; and the method is of practical value in the medical field of bone repairing.

Description

technical field [0001] The invention belongs to the field of additive manufacturing, and more specifically, relates to a method for preparing imitation coral artificial bone with cuttlebone octopus and a product thereof. Background technique [0002] Skeleton is the main component of the human body, responsible for supporting limbs, protecting organs, hematopoiesis, calcium storage and metabolism and other important body functions. Bone defects caused by pathological changes or accidents will bring serious physical and psychological trauma to patients. Despite the bone's self-healing and regenerative capabilities, large bone defects require bone grafting and replacement therapy. Therefore, it is very important to study suitable biomaterials and their shaping and preparation methods to construct bone tissue engineering scaffolds that are highly biomimetic of natural bone in terms of composition, structure and function; natural coral is the shell secreted by coral polyps, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/18A61L27/32A61L27/50A61L27/56A61L27/58B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/3604A61L27/18A61L27/32A61L27/50A61L27/56A61L27/58A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L67/04C08L61/16
Inventor 闫春泽伍宏志潘腾史云松朱伟刘洁史玉升
Owner HUAZHONG UNIV OF SCI & TECH
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