Novel amino acid peritoneal dialysate

A peritoneal dialysate and amino acid technology, applied in the field of medicine, can solve the problems of increasing the incidence of cardiovascular disease in dialysis patients, lack of anti-oxidative stress damage, insufficient amino acid concentration, etc., to achieve anti-oxidative stress effect, ultrafiltration drug The effect of improving the efficiency and improving the efficacy of ultrafiltration

Inactive Publication Date: 2018-03-30
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a new type of amino acid peritoneal dialysis solution, which solves the technical problems of lack of anti-oxidative stress damage in the existing amino acid peritoneal dialysis solution, increased incidence of cardiovascular diseases in dialysis patients, low efficacy of dialysis drugs, insufficient concentration of some amino acids, etc.

Method used

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  • Novel amino acid peritoneal dialysate
  • Novel amino acid peritoneal dialysate
  • Novel amino acid peritoneal dialysate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A new type of amino acid peritoneal dialysis solution, the components and component concentrations are: N-acetyl-L-cysteine ​​25mmol / L, L-histidine 5.6mmol / L, L-isoleucine 6.47mmol / L , L-leucine 7.77mmol / L, L-lysine 5.23mmol / L, L-phenylalanine 3.45mmol / L, L-threonine 5.41mmol / L, L-tryptophan 1.32mmol / L L, L-valine 11.89mmol / L, L-alanine 10.67mmol / L, glycine 6.78mmol / L, L-proline 5.17mmol / L, L-serine 4.84mmol / L, L-tyrosine Acid 5.4mmol / L, pH value is 6.4.

[0022] It also includes buffer base and electrolyte. The buffer base can be at least one of lactate, citrate, isocitrate, pyruvate, succinate, fumarate, malate, and oxaloacetate. The embodiment selects sodium lactate, and the concentration of sodium lactate is 42mmol / L; Electrolyte kind and each concentration are CaCl 2 2H 2 O 1.25mmol / L, MgCl 2 ·6H 2 O0.25mmol / L, NaCl 92mmol / L.

[0023] Of course, at least one of vasodilators, diuretics, hormones, vitamins, and antioxidants can be added to the amino acid perito...

Embodiment 2

[0025] A new type of amino acid peritoneal dialysis solution, the components and component concentrations are: N-acetyl-L-cysteine ​​20mmol / L, L-histidine 6.5mmol / L, L-isoleucine 6.47mmol / L , L-leucine 7.77mmol / L, L-lysine 5.23mmol / L, L-phenylalanine 3.45mmol / L, L-threonine 5.41mmol / L, L-tryptophan 1.32mmol / L L, L-valine 11.89mmol / L, L-alanine 10.67mmol / L, glycine 6.78mmol / L, L-proline 5.17mmol / L, L-serine 4.84mmol / L, L-tyrosine Acid 4.8mmol / L, pH value is 6.8.

[0026] It also includes buffer base and electrolyte. The buffer base can be at least one of lactate, citrate, isocitrate, pyruvate, succinate, fumarate, malate, and oxaloacetate. The embodiment selects sodium lactate, and the concentration of sodium lactate is 42mmol / L; Electrolyte kind and each concentration are CaCl 2 2H 2 O 1.25mmol / L, MgCl 2 ·6H 2 O0.25mmol / L, NaCl 92mmol / L.

[0027] Of course, at least one of vasodilators, diuretics, hormones, vitamins, and antioxidants can be added to the amino acid perito...

Embodiment 3

[0029] A new type of amino acid peritoneal dialysis solution, the components and component concentrations are: N-acetyl-L-cysteine ​​15mmol / L, L-histidine 7.4mmol / L, L-isoleucine 6.47mmol / L , L-leucine 7.77mmol / L, L-lysine 5.23mmol / L, L-phenylalanine 3.45mmol / L, L-threonine 5.41mmol / L, L-tryptophan 1.32mmol / L L, L-valine 11.89mmol / L, L-alanine 10.67mmol / L, glycine 6.78mmol / L, L-proline 5.17mmol / L, L-serine 4.84mmol / L, L-tyrosine Acid 4.0mmol / L, pH value is 5.5.

[0030] It also includes buffer base and electrolyte. The buffer base can be at least one of lactate, citrate, isocitrate, pyruvate, succinate, fumarate, malate, and oxaloacetate. The embodiment selects sodium lactate, and the concentration of sodium lactate is 42mmol / L; Electrolyte kind and each concentration are CaCl 2 2H 2 O 1.25mmol / L, MgCl 2 ·6H 2 O0.25mmol / L, NaCl 92mmol / L.

[0031] At least one of vasodilators, diuretics, hormones, vitamins, and antioxidants can be added to the amino acid peritoneal dialys...

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Abstract

The invention provides a novel amino acid peritoneal dialysate and relates to the technical field of peritoneal dialysis. The novel amino acid peritoneal dialysate comprises N-acetyl-L-cysteine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-phenylalanine and other amino acids. The novel amino acid peritoneal dialysate comprises buffer base, an electrolyte and the like; the buffer base is any one of lactate, citrate, isocitrate, pyruvate, succinate, fumarate, malate and oxaloacetate; the electrolyte comprises sodium ions, calcium ions, magnesium ions and chloride ions. The novel amino acidperitoneal dialysate provided by the invention has the benefits of better ultra-filtration drug effect, capability of preventing cardiovascular complications, stronger antioxidant stress capability and the like.

Description

technical field [0001] The invention provides a novel amino acid peritoneal dialysis solution, which relates to the technical field of medicine. Background technique [0002] Currently, peritoneal dialysis is a commonly used end-stage renal replacement therapy. Compared with hemodialysis, its advantages are relatively low cost of treatment, simple operation, not dependent on large dialysis equipment, home treatment can be achieved, and there are fewer restrictions on the freedom of life of patients. Therefore, the promotion of peritoneal dialysis therapy is especially in line with the current national conditions of our country. Therefore, the number of patients receiving peritoneal dialysis is increasing year by year. However, the most commonly used lactate peritoneal dialysis solution in my country uses high-concentration glucose as the main osmotic agent. Long-term use by patients will cause a large amount of glucose to be absorbed into the body through the peritoneum, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/198A61K31/4172A61K31/405A61K31/401A61K45/06A61P9/00A61P7/08
CPCA61K9/08A61K31/198A61K31/401A61K31/405A61K31/4172A61K45/06A61K2300/00
Inventor 王刚沈圣民冯新光
Owner HUAREN PHARMACEUTICAL CO LTD
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