Chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome and preparation method of chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome

A technology of osmanthus phenylethanol glycoside and phenylethanol glycoside, which is applied in the field of chitosan-coated osmanthus phenylethanol glycoside liposome and its preparation, can solve the problem of unstable liposome structure, large particle size, and core material Leakage and other problems can be achieved to increase the slow-release effect, improve stability, and prevent aggregation

Active Publication Date: 2018-05-08
ZHEJIANG UNIV
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the liposome structure is unstable, and there are problems such as heat se...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome and preparation method of chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome
  • Chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome and preparation method of chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome
  • Chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome and preparation method of chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Weigh 1 g of soybean lecithin, 0.05 g of cholesterol, and 0.5 g of osmanthus phenylethanol glycoside, dissolve them in 50 mL of absolute ethanol, and sonicate for 10 min to obtain a uniform lipid ethanol solution. Rapidly inject the lipid ethanol solution into 2 times the volume of phosphate buffer solution (phosphate buffer solution with a pH value of 6.0 and a concentration of 0.01M) to obtain the osmanthus phenylethanol glycoside liposome suspension. Concentrate the suspension under reduced pressure (0.010 MPa, temperature is 40° C.), recover ethanol, and obtain osmanthus phenylethanol glycoside liposome solution (osmanthus phenylethanol glycoside nanoliposome solution). Weigh 100 mg of chitosan and dissolve (dissolve with magnetic stirring) in 100 mL of 1% (volume %) glacial acetic acid solution to obtain a chitosan solution. Add the above liposome solution dropwise (dropping time is 20-30 minutes) into the chitosan solution, the stirring speed of the magnetic stirr...

Embodiment 2

[0068] Weigh 1 g of soybean lecithin, 0.05 g of osmanthus phenylethanol glycoside, and 0.10 g of cholesterol, dissolve them in 50 mL of absolute ethanol, and sonicate for 10 min to obtain a uniform lipid ethanol solution. Rapidly inject the lipid ethanol solution into 2 times the volume of phosphate buffer solution (phosphate buffer solution with a pH value of 6.0 and a concentration of 0.01M) to obtain the osmanthus phenylethanol glycoside liposome suspension. Concentrate the suspension under reduced pressure (0.010 MPa, temperature is 40° C.), recover ethanol, and obtain osmanthus phenylethanol glycoside liposome solution (osmanthus phenylethanol glycoside nanoliposome solution). Weighing 100mg of chitosan was dissolved in 100mL of 1% glacial acetic acid solution to obtain a chitosan solution. The liposome solution was added dropwise into the chitosan solution, the stirring speed of the magnetic stirrer was 500 rpm / min during the whole process, and the mixed solution was inc...

Embodiment 3

[0080] Weigh 1 g of soybean lecithin, 0.10 g of osmanthus phenylethanol glycoside, and 0.10 g of cholesterol, dissolve them in 50 mL of absolute ethanol, and sonicate for 10 min to obtain a uniform lipid ethanol solution. Rapidly inject the lipid ethanol solution into 2 times the volume of phosphate buffer solution (phosphate buffer solution with a pH value of 6.0 and a concentration of 0.01M) to obtain the osmanthus phenylethanol glycoside liposome suspension. Concentrate the suspension under reduced pressure (0.010 MPa, temperature is 40° C.), recover ethanol, and obtain osmanthus phenylethanol glycoside liposome solution (osmanthus phenylethanol glycoside nanoliposome solution). Weighing 200mg of chitosan was dissolved in 100mL of 1% glacial acetic acid solution to obtain a chitosan solution. The liposome solution was added dropwise to the chitosan solution, the stirring speed of the magnetic stirrer was 500 rpm / min during the whole process, and the mixed solution was incub...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention relates to the technical field of healthcare food, and particularly discloses a chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome and a preparation method ofthe chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome. The preparation method adopts soybean lecithin and cholesterol as film materials, adopts an ethanol injection methodto prepare the osmanthus phenylethanoid glycosides lipidosome, and utilizes the chitosan to modify the lipidosome, thereby obtaining the chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome. The embedding rate of the chitosan-coating sweet-scented osmanthus phenylethanoid glycosides lipidosome prepared by the invention is 35.04 to 88.10 percent, and a particle size is 74.14 to 116.47 nm. The stability of the sweet-scented osmanthus phenylethanoid glycosides is improved, and the sweet-scented osmanthus phenylethanoid glycosides has a sustained release effect.

Description

technical field [0001] The invention relates to the technical field of health food, in particular to a chitosan-coated osmanthus phenylethanol glycoside liposome and a preparation method thereof. Background technique [0002] The inventor's previous invention patent 201410043501.8 discloses a phenylethanol glycoside extract from osmanthus fragrans, wherein the total phenylethanol glycoside content is 30-90% (weight %), and the verbascoside content is 25-80% (weight %). Phenylethyl glycosides have anti-inflammatory, anti-ultraviolet, neuroprotective, anti-tumor and other pharmacological effects, and can be used in medicine, health care products, food, cosmetics and other fields. Because verbascoside is easy to degrade under heat, weak alkaline and physiological environment, it is not easy to be absorbed by the human body, it is quickly eliminated in the body, and its oral bioavailability is low. These problems limit its application in food and medicine to a certain extent. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/63A61K9/127A61K47/36A23L33/105A23P10/30
CPCA23V2002/00A61K9/1271A61K36/63A61K47/36A23L33/105A23P10/30A23V2200/224A23V2250/21A23V2250/511A23V2250/1842
Inventor 陆柏益周菲宋华欣钟永恒徐涛
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap