A method for coating upconversion nanoparticles with low-temperature cyclodextrin carbonization
A nanoparticle and cyclodextrin technology, which is applied in the field of nano-fluorescent materials, can solve the problems of fluorescence quenching, cumbersome operation process, and difficult control of the thickness of the coated carbonized layer, so as to reduce biological toxicity, simple preparation process, and improve biophase capacitive effect
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Embodiment 1
[0025] 1. Prepare 50mg cyclodextrin and 40ml deionized water, and mix them to form the first mixture;
[0026] 2. Prepare 20 mg of up-conversion nanocrystals with a particle size of 100 nanometers, and disperse them in cyclohexane to form a second mixed solution;
[0027] 3. Mix the first and second mixed liquids and stir thoroughly for 2 hours to obtain the third mixed liquid;
[0028] 4. Heat the third mixed solution to 60°C, keep it for 80 minutes to evaporate and remove the cyclohexane, and cool to obtain a transparent aqueous solution;
[0029] 5. Add the aqueous solution into a polytetrafluoroethylene reactor, and react at 160 degrees Celsius for 16 hours under airtight conditions;
[0030] 6. The obtained product is centrifuged and washed several times, and dried to obtain a carbon-coated upconversion nanomaterial.
[0031] Such as Figure 1-2 Shown: It can be seen that there is a thin layer of carbon coated on the surface of up-conversion nanocrystals NaYF4:Yb,Er. ...
Embodiment 2～7
[0033] As in Example 1, the volume of the reaction solution, the temperature, and the time operating conditions are constant, and the quality of the cyclodextrin and the up-conversion quality are changed to test: the specific information is as follows:
[0034] serial number Cyclodextrin quality Upconversion quality Example 2 100mg 20mg Example 3 200mg 20mg Example 4 300mg 20mg Example 5 400mg 20mg Example 6 500mg 20mg Example 7 600mg 20mg
[0035] Such as figure 1 and figure 2 The comparison shows: It can be seen that there is a thin layer of carbon coated on the surface of the up-conversion nanocrystal NaYF4:Yb, Er.
[0036] The prepared cyclodextrin carbon coating layer effectively reduces the biological toxicity, improves its biocompatibility, and can prevent the agglomeration of nanoparticles. The preparation process is simple, and it is beneficial to further modification and application.
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