Implant active surface

An active surface and implant technology, applied in surface reactive electrolytic coating, prosthesis, liquid chemical plating, etc., can solve problems such as implant failure, and achieve the effect of increasing roughness, mild preparation conditions, and high stability

Inactive Publication Date: 2018-06-12
DALIAN SANSHENG SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, due to the biological inertness of titanium, when the implant area h

Method used

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  • Implant active surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] An implant active surface, the surface of the implant has a titanium base layer, the outer surface of the titanium base layer is coated with a titanium dioxide layer containing calcium and phosphorus, and the outer surface of the titanium dioxide layer containing calcium and phosphorus is coated with A polyelectrolyte layer, the polyelectrolyte layer is composed of positively charged polylysine and negatively charged hyaluronic acid, the polyelectrolyte layer is loaded with silver to obtain a silver-loaded polyelectrolyte layer, which is prepared according to the following method:

[0035] (1) The surface of the TA4 industrial pure titanium implant was polished step by step with 200, 300, 600, 1200 and 2000 mesh sandpaper, followed by ultrasonic cleaning with acetone, ethanol and distilled water for 10 minutes, and dried to form a titanium base layer;

[0036] (2) Place the implant in step (1) in a mixed etching agent composed of hydrofluoric acid and hydrochloric acid f...

Embodiment 2

[0045] An implant active surface, the surface of the implant has a titanium base layer, the outer surface of the titanium base layer is coated with a titanium dioxide layer containing calcium and phosphorus, and the outer surface of the titanium dioxide layer containing calcium and phosphorus is coated with A polyelectrolyte layer, the polyelectrolyte layer is composed of positively charged polylysine and negatively charged hyaluronic acid, the polyelectrolyte layer is loaded with silver to obtain a silver-loaded polyelectrolyte layer, which is prepared according to the following method:

[0046] (1) The surface of the TA2 industrial pure titanium implant was polished step by step with 200, 300, 600, 1200 and 2000 mesh sandpaper, followed by ultrasonic cleaning with acetone, ethanol and distilled water for 10 minutes, and dried to form a titanium base layer;

[0047] (2) Place the implant in step (1) in a mixed etching agent composed of hydrofluoric acid and hydrochloric acid f...

Embodiment 3

[0056] An implant active surface, the surface of the implant has a titanium base layer, the outer surface of the titanium base layer is coated with a titanium dioxide layer containing calcium and phosphorus, and the outer surface of the titanium dioxide layer containing calcium and phosphorus is coated with A polyelectrolyte layer, the polyelectrolyte layer is composed of positively charged polylysine and negatively charged hyaluronic acid, the polyelectrolyte layer is loaded with silver to obtain a silver-loaded polyelectrolyte layer, which is prepared according to the following method:

[0057] (1) The surface of the TC4 titanium alloy implant was polished step by step with 200, 300, 600, 1200 and 2000 mesh sandpaper, followed by ultrasonic cleaning with acetone, ethanol and distilled water for 10 minutes, and dried to form a titanium base layer;

[0058] (2) Place the implant in step (1) in a mixed etching agent composed of hydrofluoric acid and hydrochloric acid for surface...

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Abstract

The invention discloses an implant active surface. The surface of an implant is provided with a titanium-based bottom layer, the outer surface of the titanium-based bottom layer is coated with a titanium dioxide layer comprising calcium and phosphorus, the outer surface of the titanium dioxide layer comprising the calcium and phosphorus is coated with a polyelectrolyte layer, the polyelectrolyte layer consists of polylysine with positive charges and hyaluronic acid with negative charges, and the polyelectrolyte layer is loaded with silver to obtain a silver-loading polyelectrolyte layer. By virtue of a treatment method combining acid erosion treatment, micro arc oxidation treatment and alkaline heat treatment, the implant surface has good biocompatibility, the surface free energy is increased, and the surface coarseness is increased, so that cells can be better combined with the implant, and certain bone induction capacity can be achieved; and by utilizing a layer-to-layer self-assembling technology, the polyelectrolyte with the charge characteristic and inorganic particles are introduced into the surface of the implant to establish the silver-loading polyelectrolyte layer, and byvirtue of the synergistic bacteriostatic effect of the polylysine and the silver, the implant surface has good antibacterial performance.

Description

technical field [0001] The invention relates to the field of biomedical implants, in particular to an implant active surface. Background technique [0002] Titanium and titanium alloys have good biocompatibility, corrosion resistance, and can form bone fusion with surrounding bone tissue, and are widely used in human implant materials. Since Professor Branemark of Sweden implanted the first titanium dental implant into the human body in 1965, titanium and titanium alloys have been widely used in artificial dental implants. [0003] In 1977, Japanese scholars S.Shima and H.Sakai found that an actinomycete No.346 could produce a large amount of stable DP substances in the process of screening Dragendo~Positive (abbreviated as DP) substances from microorganisms. The analysis and structural analysis of the hydrolyzed product confirmed that the DP substance is a homomonomer polymer containing 25-30 lysine residues, called ε-polylysine (ε-PL). [0004] ε-polylysine is a polypept...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/30A61L27/34A61L27/50A61L27/54C23C18/44C23F1/26C25D11/26
CPCA61L27/06A61L27/306A61L27/34A61L27/50A61L27/54C23C18/44C23F1/26C25D11/024C25D11/026C25D11/26A61L2300/404A61L2300/606A61L2400/18A61L2420/02A61L2420/08A61L2430/12A61L2300/104C08L5/08C08L77/04
Inventor 蔡俊江张久文
Owner DALIAN SANSHENG SCI & TECH DEV
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