Multiple crosslinking breast patch and preparation method thereof

A patch and breast technology, which is applied in the fields of fake breasts, medical science, tissue regeneration, etc., can solve the problems of obvious pressure, prosthesis moving down, soft tissue weakness, etc., achieve good mechanical properties and resistance to degradation, and facilitate tissue growth Injection, low immunogenicity effect

Active Publication Date: 2018-06-12
SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in actual surgery, breast soft tissue defects or insufficiency often occur due to various reasons, or the extremely soft tissue under the breast is weak, resulting in insufficient soft tissue coverage on the surface of the prosthesis. Complications such as downward movement and fibrous capsular contracture may even require surgery to remove the prosthesis in severe cases, which greatly affects the breast shape and physical appearance of the beauty seeker

Method used

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  • Multiple crosslinking breast patch and preparation method thereof
  • Multiple crosslinking breast patch and preparation method thereof
  • Multiple crosslinking breast patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A kind of preparation of 3 times cross-linked breast patch, specifically comprising:

[0041] Using bovine pericardium as the raw material, after decellularization and antigen removal treatment, it has low immunogenicity and is cross-linked by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) 3 Once, it is obtained after freeze-drying, punching, cutting, sterilization and packaging.

[0042] (1) Obtaining decellularized bovine pericardium: refer to the decellularization method in Chinese patent CN201410780482.7 to obtain decellularized bovine pericardium with low immunogenicity.

[0043]

[0044] (3) Freeze-drying: spread the three times cross-linked bovine pericardium membrane obtained in step (2) on a polytetrafluoroethylene plate or a stainless steel plate, carefully distinguish the smooth side and the rough side, make the smooth side face down, and the rough side Place face up in freeze dryer. Vacuum freeze-drying is carried out according to the preset pr...

Embodiment 2

[0049] A kind of preparation of 5 cross-linked breast patches, specifically comprising:

[0050]Using pig peritoneum as the raw material, after decellularization and antigen removal treatment, it has low immunogenicity, and has been cross-linked by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) 5 times, It is prepared after being freeze-dried, punched, cut, sterilized and packaged.

[0051] (1) Obtaining decellularized porcine peritoneum: refer to the decellularized method in Chinese patent CN201410780482.7 to obtain decellularized porcine peritoneum with low immunogenicity.

[0052]

[0053] (3) Freeze-drying: Flatten the pig peritoneum obtained in step (2) five times on a polytetrafluoroethylene plate or a stainless steel plate, carefully distinguish the smooth side and the rough side, so that the smooth side faces down and the rough side faces placed in a freeze dryer. Vacuum freeze-drying is carried out according to the preset program to obtain the freeze...

Embodiment 3

[0057] A kind of preparation of secondary cross-linked breast patch, specifically comprising:

[0058] Using bovine pericardium as the raw material, after decellularization and antigen removal treatment, it has low immunogenicity, cross-linked with genipin (GP) for 3 times, freeze-dried, punched, cut, sterilized and packaged be made of.

[0059] (1) Obtaining decellularized bovine pericardium: refer to the decellularization method in Chinese patent CN201410780482.7 to obtain decellularized bovine pericardium with low immunogenicity.

[0060]

[0061] (3) Freeze-drying: spread the secondary cross-linked bovine pericardium membrane obtained in step (2) on a polytetrafluoroethylene plate or a stainless steel plate, carefully distinguish the smooth side and the rough side, make the smooth side face down, and the rough side Place face up in freeze dryer. Vacuum freeze-drying is carried out according to the preset program to obtain the freeze-dried patch material; then the th...

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Abstract

The invention discloses a multiple crosslinking breast patch and a preparation method thereof. The patch is of a double-faced structure which comprises a smooth surface and a rough surface, a plurality of small holes are formed in the surface of the patch, and the diameter of each small hole is 0.5-2.5mm. According to the patch, an animal-based membrane material serves as a raw material, multiplecrosslinking treatment of the animal-based membrane material is performed under the action of crosslinking agents, and freeze drying and punching of the animal-based membrane material after multiple crosslinking treatment are performed to prepare the patch. The patch has good mechanical properties and degradation resistance and low immunogenicity, tissue penetration is facilitated, displacement isnot easily generated, and the patch is simple in preparation method and applicable to prosthesis breast augmentation of insufficient breast soft tissues.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and in particular relates to a multiple cross-linked breast patch and a preparation method thereof. Background technique [0002] In recent years, with the development of plastic surgery technology and women's pursuit of beauty, breast plastic surgery has become one of the increasingly popular plastic surgery. Prosthesis implantation is a common breast plastic surgery. In prosthesis breast augmentation, the surface of the prosthesis needs sufficient soft tissue coverage, and at the same time, the chest wall tissue support is required below the prosthesis to maintain the normal position of the prosthesis. However, in actual surgery, breast soft tissue defects or insufficiency often occur due to various reasons, or the extremely soft tissue under the breast is weak, resulting in insufficient soft tissue coverage on the surface of the prosthesis. Complications such as downward movement...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/36A61L27/50A61F2/12
CPCA61F2/0063A61F2/12A61F2240/001A61L27/3604A61L27/3629A61L27/3687A61L27/3691A61L27/50A61L27/56A61L2430/04A61L2430/40
Inventor 樊杏利马金霞黄文涛
Owner SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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