Multihole titanium-magnesium alloy artificial bone capable of promoting bone growth and preparation method thereof

A technology for bone growth and titanium-magnesium alloy, which is applied in the directions of additive manufacturing, tissue regeneration, and additive processing.

Active Publication Date: 2018-06-15
西安谢赫特曼诺奖新材料研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after the artificial bone formed by using porogens enters the human body, porogens such as urea will have a certain rejection reaction to the human body and will cause infection to the human bone tissue.

Method used

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  • Multihole titanium-magnesium alloy artificial bone capable of promoting bone growth and preparation method thereof
  • Multihole titanium-magnesium alloy artificial bone capable of promoting bone growth and preparation method thereof
  • Multihole titanium-magnesium alloy artificial bone capable of promoting bone growth and preparation method thereof

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preparation example Construction

[0058] The invention also discloses a porous titanium-magnesium alloy artificial bone capable of promoting bone growth and a preparation method thereof, comprising the following steps:

[0059] (1) The metal powder of the following composition (percentage by weight) is mixed into titanium alloy powder:

[0060] 0.3-9.5% molybdenum,

[0061] 1.5-6.5% nickel,

[0062] 2.5-14.5% cobalt,

[0063] 1.5-3.5% yttrium,

[0064] 1.5-5.5% niobium,

[0065] 2-3.0% magnesium,

[0066] The remainder is titanium and unavoidable impurities;

[0067] The sum of the above components is 100%;

[0068] (2) Molding method: The above-mentioned titanium-magnesium alloy powder is sintered with a German EOSINT M290 metal powder sintering system, and a selective laser sintering (SLS for short) is adopted, and the laser transmitter type is a b-fibre ytterbium fiber laser transmitter 200W or 400W, variable focal length diameter 200-480μm thickness value, optical scanning system F-theta lens, the s...

Embodiment 1

[0070] Metal powder is mixed into titanium alloy powder, wherein, described titanium alloy powder is made of the molybdenum of 0.5% (weight), and the nickel of 1.5% (weight), 2.5% cobalt, the yttrium of 1.5% (weight), 1.3% (weight) ) of niobium, .

[0071] 2% by weight of magnesium. The rest is composed of titanium and unavoidable impurities, the sum of the above components is 100%.

[0072] Molding method: The above-mentioned titanium-magnesium alloy powder is used in the German EOSINT M290 metal powder sintering system, using Selective Laser Sintering (SLS for short), and the laser transmitter type is b-fibre ytterbium fiber laser transmitter 200W, which can be The diameter of the variable focal length is 200 μm, the thickness value is 200 μm, the optical scanning system is F-theta lens, the size of the titanium-magnesium alloy artificial bone of the present invention is 260×260×315mm, and the power supply can be selected: 220V, 32A. The laser scanning speed is 6.0 m / s, an...

Embodiment 2

[0074] Metal powder is mixed into titanium alloy powder, wherein, described titanium alloy powder is made of the molybdenum of 4.5% (weight), and the nickel of 4% (weight), 7.5% cobalt, the yttrium of 2.5% (weight), 3.5% (weight) ) of niobium, .2.5% by weight of magnesium. The rest is composed of titanium and unavoidable impurities, the sum of the above components is 100%.

[0075] Molding method: The above-mentioned titanium-magnesium alloy powder is used in the German EOSINT M290 metal powder sintering system, using Selective Laser Sintering (SLS for short), and the laser transmitter type is b-fibre ytterbium fiber laser transmitter 200W, which can be The diameter of the variable focal length is 300 μm, the thickness value is 300 μm, the optical scanning system is F-theta lens, the size of the titanium-magnesium alloy artificial bone of the present invention is 260×260×315mm, and the power supply can be selected: 220V, 32A. The laser scanning speed is 6.5 m / s, and the metal...

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Abstract

The invention discloses a multihole titanium-magnesium alloy artificial bone capable of promoting bone growth and a preparation method thereof. The artificial bone is prepared from titanium-magnesiumalloy powder. The titanium-magnesium alloy powder is prepared from the following components (in percentage by weight): 0.3 to 9.5 percent of molybdenum, 1.5 to 6.5 percent of nickel, 2.5 to 14.5 percent of cobalt, 1.5 to 3.5 percent of yttrium, 1.5 to 5.5 percent of niobium, 2 to 3.0 percent of magnesium and the balance of titanium and unavoidable impurities, wherein the total percentage of all the components is 100 percent. Compared with the prior art, the multihole titanium-magnesium alloy artificial bone has the advantages that due to the addition of a molybdenum element, the intensity of the artificial bone is enhanced, and the low-temperature characteristic of the artificial bone is improved; meanwhile, according to an improved formula and an improved process, the density, the elasticity modulus, the compressive yield strength and the fracture toughness of the titanium-magnesium alloy artificial bone are closer to corresponding values of a human bone; furthermore, the artificial bone can achieve a mechanical property matched with a bone tissue by adjusting the porosity, so that a stress shielding phenomenon between the titanium-magnesium alloy artificial bone and the bone tissue is relieved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a porous titanium-magnesium alloy artificial bone capable of promoting bone growth and a preparation method thereof. Background technique [0002] Commonly used bone repair materials include autogenous bone, magnesium alloy, titanium alloy and cobalt-chromium alloy artificial bone prosthesis. Autogenous bone requires multiple operations, which increases the trauma and pain of the patient; the density, elastic modulus, compressive yield strength and fracture toughness of general titanium alloy and cobalt-chromium alloy are compared with pure titanium alloy and cobalt-chromium alloy artificial bone. are higher than the corresponding values ​​of human bones. After being implanted in the human body, the metal prosthesis is loose and broken, which increases the patient's weight and discomfort. The interface between the implant and the human bone produces a "stress shield...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/56A61L27/54A61L27/50B22F3/105B33Y10/00B33Y70/00C22C1/04C22C14/00
CPCA61L27/06A61L27/50A61L27/54A61L27/56C22C1/0458C22C14/00B33Y10/00B33Y70/00A61L2430/02A61L2300/41A61L2300/404A61L2300/102B22F10/00B22F10/322B22F10/34B22F12/41B22F10/36B22F10/28B22F12/44B22F10/38Y02P10/25
Inventor 鄢腊梅张美玲李双桐袁友伟张祥泉
Owner 西安谢赫特曼诺奖新材料研究院有限公司
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