Medicinal composition with etoricoxib and preparation method of medicinal composition

A technology of etoricoxib and composition, applied in the field of external skin preparations containing etoricoxib and preparation thereof, can solve problems such as decreased stability, poor solubility of etoricoxib, and inability to use effectively

Inactive Publication Date: 2018-06-29
BEIJING TIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Patent CN201410213170.8 discloses a gel preparation containing etoricoxib, which is a semi-solid gel. This invention uses tromethamine as a solvent to solve the problem of poor solubility of etoricoxib in water. Carbomer, pH regulator and other co-solvents were added to the preparation, and the research found that the preparation had the following disadvantages: first, the drug in the gel was easy to lose, resulting in a decrease in the efficacy and stability of the drug; secondly, The gel uses a large amount of organic solvents, which is highly irritating to the skin and easily causes skin allergies; finally, the gel is in a semi-solid state, has certain fluidity, is easy to pollute clothes, is inconvenient to use, and coagulates simultaneously. The glue is placed for a long time, the drug is easy to precipitate, and the paste becomes hard, making it unable to be used effectively

Method used

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  • Medicinal composition with etoricoxib and preparation method of medicinal composition
  • Medicinal composition with etoricoxib and preparation method of medicinal composition
  • Medicinal composition with etoricoxib and preparation method of medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032] Preparation:

[0033] 1) Add tartaric acid into pure water to obtain component A;

[0034] 2) Dissolve etoricoxib in the solution of propylene glycol and crotamiton, mix and stir evenly, component B;

[0035] 3) Weigh NP-700, carbomer, sodium carboxymethylcellulose, aluminum hydroxide, and Tween 80 into a kneading pot, add glycerin, and disperse evenly. Continue to add component B, menthol, and liquid paraffin, make it fully kneaded, and disperse evenly, then add component A, keep warm at about 40°C, mix, stir evenly, and make a paste;

[0036] 4) Apply the paste evenly, slice it, pack it, and make a patch.

Embodiment 2

[0038]

[0039] Preparation:

[0040] 1) Add gelatin to purified water, add tartaric acid after dissolving, and stir evenly to obtain component A;

[0041]2) Dissolve etoricoxib in a solution of crotamiton, nitrogen methylpyrrolidone and PEG400, mix and stir evenly to obtain component B;

[0042] 3) Weigh methylcellulose, carbomer, aluminum hydroxide, edetate disodium, and titanium dioxide into a kneading pot, add glycerin, and disperse evenly. Continue to add component B, azone, and liquid paraffin to fully knead and disperse evenly, then add component A, keep warm at about 40°C, mix, stir evenly, and make a paste;

[0043] 4) Apply the paste evenly, slice it, pack it, and make a patch.

Embodiment 3

[0045]

[0046] Preparation:

[0047] 1) Add tartaric acid into purified water and stir evenly to obtain component A;

[0048] 2) Dissolve etoricoxib in a solution of propylene glycol and crotamiton, mix and stir evenly to obtain component B;

[0049] 3) Weigh carboxymethyl cellulose, carbomer, chitosan, aluminum glycylate, disodium edetate, kaolin and methylparaben into a kneading pot, add glycerin, and disperse evenly. Continue to add component B, menthol and polybutene to make it fully kneaded and dispersed evenly, then add component A, keep warm at about 40°C, mix, stir evenly, and make a paste;

[0050] 4) Apply the paste evenly, slice it, pack it, and make a patch.

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Abstract

The invention discloses a medicinal composition with etoricoxib. According to the medicinal composition, etoricoxib is adopted as a solvent, a long-lasting external skin preparation with etoricoxib isprepared, the preparation is high in stability, medicines can be constantly and stably released, and the probability that cardiovascular diseases can be caused by a too high blood concentration afteran etoricoxib preparation is orally taken can be effectively reduced.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical composition containing etoricoxib and a preparation method thereof, in particular to an external skin preparation containing etoricoxib and a preparation method thereof. Background technique [0002] Etoricoxib, chemically named 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine, is a highly selective cyclooxygenase- 2 (COX-2) inhibitors, by inhibiting COX, reducing the production of prostaglandin (PG) and thromboxane to exert antipyretic, analgesic and anti-inflammatory effects, it can be used for rheumatoid arthritis, OA, chronic low back pain, postoperative Toothache, etc., have pain relief and anti-inflammatory effects. Compared with the first generation of COX-2 inhibitors, it has stronger selectivity, higher efficacy, and less side effects on the gastrointestinal tract. It is the only proven treatment for acute gouty Effective cox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/18A61K31/444A61K45/00A61P29/00A61P1/02A61P19/02
CPCA61K45/00A61K47/18A61K31/444
Inventor 赵焰平高莹吴昀卢迪周丽莹刘亚男
Owner BEIJING TIDE PHARMA
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