Silicon-based induced active liquid dressing and preparation method thereof

A technology of inducing activity and liquid dressing, which is applied in medical science, bandages, etc., can solve the problems of slow film formation and lack of wound repair, and achieve the effects of improving antibacterial performance, reducing bacterial infection, and good antibacterial performance

Inactive Publication Date: 2018-06-29
YICHUN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, a variety of liquid dressings have appeared in the domestic and foreign markets. After investigation, it is found that the liquid dressing products that have been listed in China, such as: polyvinyl alcohol gel of Xinxiang Huaxin Pharmaceutical Co., Ltd., Shanghai Huayi High-Tech Co., Ltd. The liquid wound protection film (Xinfujia) produced is all made of polyvinyl alcohol as the film-forming material. Since it does not use organic solvents as the main volatile solvent, the film-forming is slow
The NEW SKIN liquid band-aid with a good reputation abroad and the Coloskin liquid band-aid of Japan’s Kobayashi Pharmaceutical Company both use low-nitrogen nitrocellulose as the film-forming material. The protective film formed by this lipophilic material can effectively isolate the wound from the outside world and has excellent film-forming properties. OK, but this product only relies on the original self-healing function of the skin tissue to heal, and does not have the function of promoting wound repair

Method used

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  • Silicon-based induced active liquid dressing and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0020] A silicon-based active liquid dressing, comprising the following components in parts by weight: 6 parts of 45S5 bioactive glass powder, 0.8 part of nitrocellulose, 0.3 part of polyethylene glycol 400, 0.3 part of sodium polyaspartate aqueous solution, 0.08 1 part of benzalkonium chloride, 10 parts of organic solvent, the organic solvent is the mixture obtained by mixing butyl acetate and ethanol according to the mass ratio of 1:2.

[0021] The method for preparing the above-mentioned silicon-based inducing active liquid dressing comprises the following steps:

[0022] S1: Measure a certain amount of butyl acetate and ethanol according to the mass ratio of butyl acetate:ethanol=1:2, and then mix them uniformly to obtain an organic solvent;

[0023] S2: According to the weight ratio of 6 parts of 45S5 bioactive glass, 0.8 parts of nitrocellulose, 0.3 parts of polyethylene glycol 400, 0.3 parts of sodium polyaspartate aqueous solution, 0.08 parts of benzalkonium chloride, ...

Embodiment 2

[0027] A silicon-based active-inducing liquid dressing, comprising the following components in parts by weight: 10 parts of 45S5 bioactive glass powder, 1 part of nitrocellulose, 0.8 part of polyethylene glycol 400, 0.7 part of sodium polyaspartate aqueous solution, 0.15 1 part of benzalkonium chloride, 20 parts of organic solvent, the organic solvent is the mixture obtained by mixing butyl acetate and ethanol according to the mass ratio of 1:2.

[0028] The preparation method of the silicon-based active liquid dressing in Preparation Example 2 is the same as that in Example 1.

Embodiment 3

[0030] A silicon-based active liquid dressing, comprising the following components in parts by weight: 16 parts of 45S5 bioactive glass powder, 1.5 parts of nitrocellulose, 1.2 parts of polyethylene glycol 400, 1 part of sodium polyaspartate aqueous solution, 0.2 parts 30 parts of benzalkonium chloride, 30 parts of organic solvent, the organic solvent is the mixture obtained by mixing butyl acetate and ethanol according to the mass ratio of 1:2.

[0031] The preparation method of the silicon-based inducing active liquid dressing in Example 3 is the same as that in Example 1.

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Abstract

The invention discloses a silicon-based induced active liquid dressing and a preparation method thereof, and belongs to the technical field of medical dressing. The silicon-based induced active liquiddressing includes bioactive glass, a film forming material, a pore forming agent, an antibacterial agent, a lubricant and an organic solvent. The silicon-based induced active liquid dressing is characterized in that the film forming material is one or more of cellulose nitrate, polyacrylic acid resin I, polyacrylic acid resin II and polyacrylic acid resin III; the pore forming agent is one or more of polyethylene glycol 400, polyethylene glycol 600 and polyethylene glycol 1000; the lubricant is one or more of a polyaspartic acid aqueous solution, a polyglutamic acid aqueous solution and a sodium polyaspartate solution; the antibacterial agent is one of nano silver, benzyl alcohol and benzalkonium chloride; the organic solvent is a mixture of butyl acetate and ethanol. The prepared silicon-based induced active liquid dressing has good mechanical properties and can also provide a moist environment needed for wound surface healing.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, and in particular relates to a silicon-based active-inducing liquid dressing and a preparation method thereof. Background technique [0002] Wound dressing is a material used to bandage and cover wounds. Traditional wound dressings include natural or synthetic bandages and gauze. These wound dressings generally only play the role of simply covering the wound surface, and cannot provide a wound surface that is conducive to wound healing. Humid environment. During the healing process, the granulation tissue will slowly grow towards the center of the gauze, causing the gauze to closely adhere to the new tissue, which is difficult to remove, so it is easy to tear the new tissue during replacement, causing secondary damage to the patient . With the development of modern medicine, new liquid dressings are constantly emerging. This dressing can not only cover the wound surface, but also prov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0014A61L26/0019A61L26/0023A61L26/0061A61L26/0066A61L26/0085A61L2300/104A61L2300/208A61L2300/216A61L2300/404C08L71/02C08L77/04C08L1/18C08L33/02
Inventor 吴正平
Owner YICHUN UNIVERSITY
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