A kind of amphiphilic core-shell porous polymer microsphere and preparation method thereof

A technology of porous polymer and hydrophilic polymer, applied in the field of amphiphilic core-shell porous polymer microspheres and their preparation, can solve the problem of low universality, poor uniformity of microsphere size, lack of functional groups, etc. problems, to achieve the effect of easy control of experimental conditions, controllable pore size, and simple process
CN108276525BActive Publication Date: 2020-11-06TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2020-11-06

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Abstract

The invention discloses an amphiphilic core-shell porous polymer microsphere and a preparation method thereof. The preparation method of the amphiphilic core-shell porous polymer microspheres of the present invention comprises the following steps: a) adding the emulsion obtained after emulsifying an organic solvent, a surfactant and water into an aqueous solution of polystyrene microspheres, and stirring; b) adding hydrophobic monomers, hydrophilic monomers and initiators to surfactant aqueous solution and emulsifying; c) adding the emulsion obtained in step b) to the solution obtained in step a) and stirring; d) c) The obtained emulsion is passed through nitrogen to polymerize; e) Washed repeatedly with ethanol and deionized water, and freeze-dried to obtain the obtained emulsion. The porous polymer microspheres of the present invention use polystyrene microspheres as the basic construction unit, and the controllable synthesis of amphiphilic porous polymer microspheres can be realized by introducing hydrophilic / hydrophobic monomers, which can be used for drug release, tissue engineering, Biomolecular separation, adsorption, sensing and other fields.
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Description

technical field

[0001] The invention relates to the technical field of microsphere preparation. More specifically, it relates to an amphiphilic core-shell porous polymer microsphere and a preparation method thereof. Background technique

[0002] In recent decades, the design and controllable synthesis of porous polymer microspheres have aroused extensive research interest. Due to their advantages such as small density, large specific surface area, large internal available space, and not easy to settle, they have been used in drug release, tissue engineering, etc. , separation, adsorption, sensing and other fields have been applied.

[0003] At present, the methods for preparing porous polymer microspheres mainly include: emulsion polymerization, double emulsion method, block copolymer self-assembly and so on. Porous microspheres synthesized by emulsion polymerization have the disadvantage of single composition and lack of functional groups on the surface, so it is difficul...

Claims

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