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A kind of amphiphilic core-shell porous polymer microsphere and preparation method thereof

A technology of porous polymer and hydrophilic polymer, applied in the field of amphiphilic core-shell porous polymer microspheres and their preparation, can solve the problem of low universality, poor uniformity of microsphere size, lack of functional groups, etc. problems, to achieve the effect of easy control of experimental conditions, controllable pore size, and simple process

Active Publication Date: 2020-11-06
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Porous microspheres synthesized by emulsion polymerization have the disadvantage of a single component, lack of functional groups on the surface, and it is difficult to further modify to obtain multi-component complex polymer microspheres
Other methods such as the double emulsion method, although porous polymer microspheres can be obtained, the synthesized microspheres still have disadvantages such as poor size uniformity and uncontrollable particle size.
The uniformity of the particle size of porous microspheres can be improved with the help of microfluidic equipment, however, the method of microfluidic-assisted synthesis has the disadvantage of low yield
In addition, the block copolymer self-assembly method can also be used to prepare polymer porous microspheres. However, this method has the disadvantages of low universality and poor geometric structure controllability, which makes this method have obvious advantages in the preparation of porous microspheres. limitation

Method used

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  • A kind of amphiphilic core-shell porous polymer microsphere and preparation method thereof
  • A kind of amphiphilic core-shell porous polymer microsphere and preparation method thereof
  • A kind of amphiphilic core-shell porous polymer microsphere and preparation method thereof

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Experimental program
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Embodiment 1

[0038] Embodiment 1 Amphiphilic porous polymer microsphere

[0039] A preparation method of amphiphilic porous polymer microspheres, comprising the following steps:

[0040] a) Add the emulsified emulsion containing 0.1mL dodecane chloride to 20mL aqueous solution of polystyrene microspheres with a concentration of 10mg / mL, and stir at 40°C for 24h, wherein the diameter of the polystyrene microspheres is 2μm ;

[0041] b) Add 20mmol of styrene, 7mmol of divinylbenzene, 0.2mmol of azobisisobutyronitrile initiator, and 5mmol of acrylamide into 15mL of sodium dodecylsulfonate aqueous solution with a concentration of 0.003g / mL, and emulsify for 1min;

[0042] c) adding the hydrophilic / hydrophobic monomer emulsion obtained in step b) to the solution obtained in step a), and stirring at 40°C for 6h;

[0043] d) pass the emulsion obtained in step c) into N 2 10min, stirring and reacting for 24h at a polymerization temperature of 70°C;

[0044] e) The solution obtained from the r...

Embodiment 2

[0046] Embodiment 2 Amphiphilic porous polymer microspheres

[0047]A preparation method of amphiphilic porous polymer microspheres, comprising the following steps:

[0048] a) Add the emulsified emulsion containing 0.1 mL of toluene to 20 mL of an aqueous solution of polystyrene microspheres with a concentration of 10 mg / mL, and stir at 30° C. for 12 h, wherein the diameter of the polystyrene microspheres is 0.8 μm;

[0049] b) 30mmol α-methylstyrene, 20mmol divinylbenzene, 0.3mmol azobisisoheptanonitrile initiator, and 8mmol acrylic acid are added to 15mL concentration of 0.002g / mL sodium dodecylbenzenesulfonate aqueous solution, Emulsify for 3 minutes;

[0050] c) adding the hydrophilic / hydrophobic monomer emulsion obtained in step b) to the solution obtained in step a), and stirring at 30° C. for 10 h;

[0051] d) pass the emulsion obtained in step c) into N 2 20min, stirring and reacting for 12h at a polymerization temperature of 65°C;

[0052] e) The solution obtain...

Embodiment 3

[0054] Embodiment 3 Amphiphilic porous polymer microspheres

[0055] A preparation method of amphiphilic porous polymer microspheres, comprising the following steps:

[0056] a) Add the emulsified emulsion containing 0.02mL bromododecane to 5mL aqueous solution of polystyrene microspheres with a concentration of 1mg / mL, and stir at 20°C for 36h, wherein the diameter of polystyrene microspheres is 1.2μm ;

[0057] b) 10mmol o-chlorostyrene, 7mmol divinylbenzene, 1mmol azobicyclohexylcarbonitrile initiator, and 50mmol acrylamide are added to 5mL concentration of 0.005g / mL sodium dodecylsulfonate aqueous solution, Emulsify for 1min;

[0058] c) adding the hydrophilic / hydrophobic monomer emulsion obtained in step b) to the solution obtained in step a), and stirring at 20° C. for 5 h;

[0059] d) pass the emulsion obtained in step c) into N 2 10min, stirring and reacting for 8h at a polymerization reaction temperature of 80°C;

[0060] e) The solution obtained from the reacti...

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Abstract

The invention discloses an amphiphilic core-shell porous polymer microsphere and a preparation method thereof. The preparation method of the amphiphilic core-shell porous polymer microspheres of the present invention comprises the following steps: a) adding the emulsion obtained after emulsifying an organic solvent, a surfactant and water into an aqueous solution of polystyrene microspheres, and stirring; b) adding hydrophobic monomers, hydrophilic monomers and initiators to surfactant aqueous solution and emulsifying; c) adding the emulsion obtained in step b) to the solution obtained in step a) and stirring; d) c) The obtained emulsion is passed through nitrogen to polymerize; e) Washed repeatedly with ethanol and deionized water, and freeze-dried to obtain the obtained emulsion. The porous polymer microspheres of the present invention use polystyrene microspheres as the basic construction unit, and the controllable synthesis of amphiphilic porous polymer microspheres can be realized by introducing hydrophilic / hydrophobic monomers, which can be used for drug release, tissue engineering, Biomolecular separation, adsorption, sensing and other fields.

Description

technical field [0001] The invention relates to the technical field of microsphere preparation. More specifically, it relates to an amphiphilic core-shell porous polymer microsphere and a preparation method thereof. Background technique [0002] In recent decades, the design and controllable synthesis of porous polymer microspheres have aroused extensive research interest. Due to their advantages such as small density, large specific surface area, large internal available space, and not easy to settle, they have been used in drug release, tissue engineering, etc. , separation, adsorption, sensing and other fields have been applied. [0003] At present, the methods for preparing porous polymer microspheres mainly include: emulsion polymerization, double emulsion method, block copolymer self-assembly and so on. Porous microspheres synthesized by emulsion polymerization have the disadvantage of single composition and lack of functional groups on the surface, so it is difficul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F257/02C08F212/08C08F212/32C08F220/24C08F220/14C08F212/14C08F212/12C08F220/18C08F212/36C08F220/56C08F220/06C08F228/02C08F220/20C08F222/02C08F220/54
CPCC08F212/36C08F220/06C08F220/20C08F220/54C08F220/56C08F222/02C08F228/02C08F257/02C08F220/18C08F212/14C08F220/1802
Inventor 王树涛宋永杨樊俊兵
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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