Adsorption resin for blood perfusion and preparation method thereof, and perfusion device

A hemoperfusion and adsorption resin technology, applied in the field of perfusion devices, can solve the problems of toxic side effects, acute kidney poisoning, etc., and achieve the effects of high selectivity, high adsorption rate, and good blood compatibility

Active Publication Date: 2018-07-24
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Heavy metal chelating agents are currently the main drug for treating heavy metal and radioactive element poisoning patients. This type of drug enters the human body through intravenous injection, and uses the mechanism of action of chelating agents and heavy metal ions to form soluble complexes to achieve the purpose of removal. Chelating agents often have certain toxic and side effects on the human body, and even lead to acute kidney poisoning and serious problems such as renal failure.

Method used

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  • Adsorption resin for blood perfusion and preparation method thereof, and perfusion device
  • Adsorption resin for blood perfusion and preparation method thereof, and perfusion device

Examples

Experimental program
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Effect test

Embodiment 1

[0039] The adsorbent resin for hemoperfusion of this embodiment is prepared by the following method:

[0040] (1) Chlorine ball amination

[0041] Mix 500g of cross-linked polystyrene chlorine balls (10% chlorine content), 3000g of dichloroethane and 200g of polyethyleneimine, react at 40°C for 20h, and purify to obtain an aminated polystyrene resin.

[0042] (2) Ligand activation

[0043] Dissolve 500g polycarboxyl chelating agent sodium diethyltriaminepentaacetate in 3000g tetramethylethylenediamine-hydrochloric acid buffer solution, stir evenly at room temperature, regulate and control the solution pH to 4.5, obtain polycarboxylate chelating agent solution; In the mixture solution, add 200g of N-hydroxysulfosuccinimide and 100g of condensing agent 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, and stir in the dark at 30°C After 24 hours, an activated polycarboxylate chelating agent solution was obtained.

[0044] (3) Grafting

[0045] Stir and mix 100g of aminated polys...

Embodiment 2

[0048] The adsorbent resin for hemoperfusion of this embodiment is prepared by the following method:

[0049] (1) Chlorine ball amination

[0050] Mix 500g of chlorine balls (15% chlorine content), 1000g of dimethyl sulfoxide and 500g of triethylenetetramine, react at 80°C for 2h, and purify to obtain an aminated polystyrene resin.

[0051] (2) Ligand activation

[0052] Dissolve 500g of polycarboxyl chelating agent diethyltriaminepentaacetic acid in 2000g of acetic acid-sodium acetate buffer solution, stir evenly at room temperature, and adjust the pH of the solution to 3.8 to obtain a polycarboxyl chelating agent solution; in the polycarboxyl chelating agent solution, add 800 g of N-hydroxysulfosuccinimide and 1000 g of condensing agent dicyclohexylcarbodiimide were stirred and reacted at 50°C for 2 hours in the dark to obtain an activated polycarboxylate chelating agent solution.

[0053] (3) Grafting

[0054] Stir and mix 100g of aminated polystyrene resin obtained in s...

Embodiment 3

[0056] The adsorbent resin for hemoperfusion of this embodiment is prepared by the following method:

[0057] (1) Chlorine ball amination

[0058] Mix 500g of chlorine balls (chlorine content is 0.5%), 500g of N,N-dimethylformamide and 5g of N-hydroxyethylethylenediamine, react at 20°C for 40h, and purify to obtain aminated polyphenylene Vinyl.

[0059] (2) Ligand activation

[0060] 500g polycarboxyl chelating agent sodium ethylenediaminetetraacetate is dissolved in 5000g tetramethylethylenediamine / hydrochloric acid buffer solution, stir at room temperature, control solution pH to 3, obtain polycarboxyl chelating agent solution; 50 g of N-hydroxysulfosuccinimide and 5000 g of condensing agent N,N-diisopropylcarbodiimide were added, and stirred and reacted at 35° C. in the dark for 12 hours to obtain an activated polycarboxylate chelating agent solution.

[0061] (3) Grafting

[0062] Stir and mix 100g of aminated polystyrene resin obtained in step (1) with 1000g of water,...

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Abstract

The invention relates to adsorption resin for blood perfusion and a preparation method thereof, and a perfusion device. The adsorption resin for blood perfusion is mainly formed by performing covalentlinkage on crosslinked polystyrene microspheres and polyamine compounds as well as grafting a multi-carboxyl chelating agent by the polyamine compounds. The preparation method comprises the steps ofaminating micrococcus chlorines, activating ligand and grafting. The perfusion device comprises the adsorption resin for blood perfusion. The adsorption resin for blood perfusion, which is provided orprepared by the invention, has high selective adsorption property on heavy metal and radionuclide, has high blood compatibility and is suitable for blood perfusion of human bodies or animal bodies.

Description

technical field [0001] The present invention relates to an adsorbent resin for hemoperfusion and its preparation method and application field, in particular to an adsorbent resin for hemoperfusion that can be used to adsorb heavy metal ions and radioactive elements in the human body, a preparation method of the adsorbent and perfusion using the adsorbent device. Background technique [0002] The rapid development and application of industry and nuclear energy, while bringing huge economic and social benefits to human society, also poses a serious threat to the environment due to the increasing amount of heavy metals and radioactive elements contained in wastewater and waste. Heavy metals and radioactive elements are also very harmful to organisms. Heavy metals such as lead, chromium, and mercury can be transferred into the human body through the food chain. Public safety incidents such as nuclear power plant leakage accidents, nuclear tests, and nuclear proliferation will e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/36
CPCA61M1/3687B01J20/265B01J20/28085
Inventor 董凡刘云鸿邵柯
Owner JAFRON BIOMEDICAL
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