Lactoferrin vagina expansion suppository and preparation method thereof

A vaginal expansive suppository and lactoferrin technology, applied in peptide/protein components, suppository delivery, pharmaceutical formulations, etc., can solve the problems of metronidazole adverse reactions, metronidazole cancer risk, low biological safety, etc., to promote Effectiveness of the medicine, against the effect caused by Candida albicans

Inactive Publication Date: 2018-07-27
霍尔果斯汉智医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, metronidazole is easy to cause adverse reactions, and metronidazole has a risk of carcinogenicity and low biological safety.

Method used

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  • Lactoferrin vagina expansion suppository and preparation method thereof
  • Lactoferrin vagina expansion suppository and preparation method thereof
  • Lactoferrin vagina expansion suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054]

[0055]

[0056] Preparation:

[0057] (1) Preparation of drug-containing matrix:

[0058] a) mixing the emulsifier, stabilizer and sustained-release agent in a water bath to obtain an oil phase;

[0059] b) dispersing the mixed solution containing lactoferrin and Bingbo powder as the water phase in the oil phase of step a) to obtain a pre-emulsion;

[0060] c) performing rapid membrane emulsification on the pre-emulsion obtained in step (b), and passing through a microporous membrane with a pore size of 1.5 μm to obtain a drug-containing matrix;

[0061] (2) Pour the drug-containing matrix into a suppository mold, insert an expansion carrier, attach and shape it, and prepare a suppository.

Embodiment 2

[0063]

[0064] The preparation method is the same as in Example 1.

Embodiment 3

[0066]

[0067] The preparation method is the same as in Example 1.

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Abstract

The invention provides a lactoferrin vagina expansion suppository as well as a preparation method and application thereof. The expansion suppository is prepared from lactoferrin, Bingpeng San, a basematerial and an expandable expansion carrier, wherein the expansion suppository is also prepared from lactobacillus and / or lactococcus, preferably a combination of the lactobacillus and the lactococcus. According to the vagina expansion suppository provided by the invention, effective components including the Bingpeng San, the lactobacillus and the like are combined and utilized to synergisticallyincrease the medicinal effect and improve a vagina flora environment; components including the base material, a stabilizing agent, an emulsifier, a slow release agent and the like are combined and proportioned, so that the bioavailability is improved, and bacterial vaginitis, trichomonal vaginitis and fungal vaginitis can be effectively treated.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, and relates to a vaginal expansion suppository and a preparation method thereof, in particular to a lactoferrin vaginal expansion suppository and a preparation method thereof. Background technique [0002] Vaginitis is a common gynecological disease. Under the stimulation of inflammation, it causes vulvar itching, burning pain and abnormal discharge. It is mainly divided into bacterial vaginosis, candida vaginitis and trichomonas vaginitis. Under normal circumstances, there are aerobic bacteria and anaerobic bacteria living in the vagina to form a normal vaginal flora. Any reason that breaks the ecological balance between the vagina and the flora can also form conditional pathogenic bacteria, such as Candida Vaginitis. Lactoferrin is an important non-heme iron-binding glycoprotein in milk. It is a monosaccharide protein with bactericidal activity. It has strong biological functions such as s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/40A61K9/02A61K47/46A61P15/02A61P31/04A61P31/10A61P33/02A61K31/045A61K33/22A61K35/744A61K35/747
CPCA61K9/0034A61K9/02A61K31/045A61K33/22A61K35/744A61K35/747A61K38/40A61K47/46A61K2300/00
Inventor 林淼
Owner 霍尔果斯汉智医药科技有限公司
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