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A kind of hydroxyapatite-carbon nitride composite particle and its in-situ composite process

A technology of hydroxyapatite and composite particles, which is applied in the field of biomedical materials, can solve the problems of no fluorescence characteristics, the inability to explore the interaction toxicity and side effects, etc., and achieve the effect of high drug loading rate, biological activity and low cytotoxicity

Active Publication Date: 2021-04-13
NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that hydroxyapatite has no fluorescence characteristics when it is used as a drug carrier, it is impossible to explore the interaction between it and cells, and to improve the toxic and side effects of fluorescent particles and hydroxyapatite compounding into cells, the invention proposes for the first time Two C with good biocompatibility 3 N 4 The compound and hydroxyapatite are prepared into composite particles. The technical scheme of the present invention is to use cyanamide as the carbon nitride raw material, diammonium hydrogen phosphate and calcium nitrate as the hydroxyapatite raw material, and combine them by in-situ compounding and co-sintering Preparation of Composite Nanoparticles by Process

Method used

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  • A kind of hydroxyapatite-carbon nitride composite particle and its in-situ composite process
  • A kind of hydroxyapatite-carbon nitride composite particle and its in-situ composite process
  • A kind of hydroxyapatite-carbon nitride composite particle and its in-situ composite process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] (1) Prepare 50 parts of calcium nitrate aqueous solution with a concentration of 0.1M, add 0.1 part of dicyandiamide into the above solution, stir to dissolve and mix well.

[0016] (2) Prepare 30 parts of diammonium hydrogen phosphate aqueous solution with a concentration of 0.1M, slowly add it to the above solution, and stir for 0.5 hours.

[0017] (3) Under stirring conditions, remove the water in the mixed solution by heating or freeze-drying.

[0018] (4) Put the obtained compound into a high-temperature furnace to heat at a heating rate of 5°C / min. Keep at 350°C for 4 hours, and grind the sintered product into powder.

Embodiment 2

[0020] (1) Prepare 50 parts of calcium nitrate aqueous solution with a concentration of 5M, add 10 parts of melamine into the above solution, stir to dissolve and mix well.

[0021] (2) Prepare 30 parts of 5M diammonium hydrogen phosphate aqueous solution, slowly add it to the above solution, and stir for 5 hours.

[0022] (3) Under stirring conditions, remove the water in the mixed solution by heating or freeze-drying.

[0023] (4) Put the obtained composite into a high-temperature furnace and heat at a heating rate of 1°C / min. Keep at 600°C for 1 hour, and grind the sintered product into powder.

Embodiment 3

[0025] (1) Prepare 50 parts of calcium nitrate aqueous solution with a concentration of 2.5M, add 5 parts of cyanamide to the above solution, stir to dissolve and mix well.

[0026] (2) Prepare 30 parts of diammonium hydrogen phosphate aqueous solution with a concentration of 2.5M, slowly add it to the above solution, and stir for 3 hours.

[0027] (3) Under stirring conditions, remove the water in the mixed solution by heating or freeze-drying.

[0028] (4) Put the obtained compound into a high-temperature furnace to heat at a heating rate of 10°C / min. Keep at 500°C for 3 hours, and grind the sintered product into powder.

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Abstract

The present invention uses the in-situ composite method to realize the molecular level mixing of the precursor material of carbon nitride and the preparation raw material of hydroxyapatite under liquid conditions, and prepares nano-hydroxyapatite / carbon nitride fluorescence by high-temperature calcination. Particle Nanocomposite Particles. The composite particle prepared by the invention combines the excellent biocompatibility of the two materials and has extremely low cytotoxicity. The prepared composite not only retains the high drug loading rate and biological activity of the hydroxyapatite material itself, but also uses the good fluorescence properties of carbon nitride to endow the composite particles with photoluminescent performance, which can be used as a tracer Drug carrier.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to fluorescent composite particles of hydroxyapatite and carbon nitride and an in-situ composite process thereof. Background technique [0002] Hydroxyapatite is the main inorganic component of human bones and teeth. It has good biocompatibility, bioactivity and osteoinductivity, and has been widely used as an excellent artificial bone material and drug carrier material. The pore structure and high surface energy of nano-scale hydroxyapatite enable it to adsorb organic macromolecules, and the porous structure can play a role in the sustained release of drugs. As a nanomaterial, hydroxyapatite has strong permeability. When used as a drug carrier, it can improve the penetration of drugs through biomembranes, allowing drugs to enter cells to exert their medicinal effects. However, when hydroxyapatite is used as a single drug carrier, it cannot realize the functions of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K47/69A61K49/00B82Y5/00
CPCA61K47/02A61K49/0019A61K49/005A61K47/6949B82Y5/00
Inventor 左桂福郭赵梁刘珊珊
Owner NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY