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Magnetic nanoparticles and flowing preparation method and system thereof

A technology for magnetic nanoparticles and preparation systems, applied in the field of magnetic nanoparticles and their flow preparation, can solve problems such as changes, unpredictable particle size and particle size distribution, achieve high crystallinity, optimize stability and repeatability, and improve transmission. The effect of mass heat transfer rate

Inactive Publication Date: 2018-07-31
苏州欣影生物医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the complexity of the pyrolysis reaction, which not only includes the nucleation and growth process of nanoparticles, but also the thermal decomposition reaction process of the reaction precursor, the heat and mass transfer process between the reactor and the reaction liquid during the preparation process It has an extremely important impact on the size and particle size distribution of nanoparticles, and random fluctuations in reaction parameters can easily lead to unpredictable changes in particle size and particle size distribution

Method used

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  • Magnetic nanoparticles and flowing preparation method and system thereof
  • Magnetic nanoparticles and flowing preparation method and system thereof
  • Magnetic nanoparticles and flowing preparation method and system thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 - Flow Preparation System

[0052] refer to figure 1 As shown, the flow preparation system of this embodiment includes a controller and sequentially arranged sampling channels, reactors, coolers, back pressure valves, and sample receiving containers (sample bottles); there is one sampling channel, and the sampling channel There is a sampling valve and a sampling pump on the top, and the reactor includes a heating unit, a temperature feedback unit and a pressure feedback unit;

[0053] The controller controls the work of the sampling valve and the sampling pump on the sampling channel to control the time and flow rate of the fluid in the sampling channel flowing to the reactor;

[0054] The temperature feedback unit detects the temperature in the reactor and transmits it to the controller, and the controller controls the operation of the heating unit according to the received temperature signal to control the reaction temperature in the reactor;

[0055] The ...

Embodiment 2

[0057] Example 2 - Flow Preparation System

[0058] refer to Figure 6 As shown, in the flow preparation system of this embodiment, the number of sampling channels is multiple, and each sampling channel is provided with a sampling valve and a sampling pump respectively. A mixer is also connected to mix the reagents flowing out from each sampling channel. The mixer can be an existing T-type, Y-type or static mixer, which is used to mix various raw materials to form a mixed reaction solution, which is then passed into the reactor for reaction.

[0059] The settings of the controller, reactor, cooler, back pressure valve and sample receiving container in this embodiment are the same as those in Embodiment 1.

Embodiment 3

[0060] Example 3 - Flow Preparation Method

[0061] The flow preparation method of the magnetic nanoparticles of the present embodiment comprises the steps of:

[0062] S1, dissolving the organometallic compound or metal salt compound precursor and small molecules with alkyl chains in a solvent to form a reaction solution;

[0063] S2, passing the reaction solution into a flow preparation system, the flow preparation system includes a flow rate controllable sampling channel, a temperature and pressure controllable reactor, a cooling device and a sample receiving container, the sampling channel, the reactor , the cooling device and the sample receiving container are connected in sequence;

[0064] Control the fluid flow rate in the sampling channel, and pass the reaction solution into the reactor through the sampling channel;

[0065] Control the temperature and pressure in the reactor so that the reaction solution is in a supercritical state in the reactor to react to obtain...

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Abstract

The invention discloses magnetic nanoparticles and a flowing preparation method and system thereof. In preparation, an organic metal compound or a metal salt compound precursor and alkyl chain-containing micromolecules are dissolved into a solvent to form a mixed reaction solution; next, the mixed reaction solution is pumped into a flowing preparation system, and the mixed reaction solution is ina supercritical state in a reactor to be reacted by virtue of controllable temperature and pressure; and then the magnetic nanoparticle product is obtained through deposition and separation. By virtueof the method and the flowing preparation system disclosed in the invention, the obtained magnetic nanoparticles have paramagnetism, superparamagetism, ferrimagnetism or ferromagnetism, and the surfaces of the magnetic nanoparticles are modified by the alkyl chain-containing micromolecules; compared with the conventional kettle type reaction, the flowing synthetic technique disclosed in the invention can greatly improve mass and heat transfer rate, so that high degree of crystallinity of product particles and narrow size distribution are achieved; and meanwhile, the flowing preparation systemcan be automatically controlled, so that the products are relatively low in difference and high in repeatability in different batches of preparation, and large-scale preparation of the nanoparticlescan be realized by continuous sampling.

Description

technical field [0001] The invention relates to the technical fields of material chemistry, nano science and fine chemical industry, in particular to a magnetic nano particle and its flow preparation method and system. Background technique [0002] Due to their unique magnetic properties, magnetic nanoparticles have been widely used in the fields of magnetic resonance imaging, drug delivery, hyperthermia, and biological separation, especially superparamagnetic iron oxide nanoparticles and gadolinium-containing paramagnetic nanoparticles in tumor diagnosis. The field shows broad prospects for clinical application. However, so far, almost all magnetic nanomaterials are synthesized by kettle (flask) reaction, not only the output is small, but also the difference between batches is large. the biggest bottleneck. [0003] As an emerging preparation method, flow synthesis provides a new option for the synthesis of nanoparticles (Angew.Chem., Int.Ed., 2010, 49, 6268; Chem.Soc.Rev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/01H01F41/00
CPCH01F1/01H01F41/00
Inventor 赵恩宇曾剑峰
Owner 苏州欣影生物医药技术有限公司
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