Magnetic nanoparticles and flowing preparation method and system thereof

Abstract

The invention discloses magnetic nanoparticles and a flowing preparation method and system thereof. In preparation, an organic metal compound or a metal salt compound precursor and alkyl chain-containing micromolecules are dissolved into a solvent to form a mixed reaction solution; next, the mixed reaction solution is pumped into a flowing preparation system, and the mixed reaction solution is ina supercritical state in a reactor to be reacted by virtue of controllable temperature and pressure; and then the magnetic nanoparticle product is obtained through deposition and separation. By virtueof the method and the flowing preparation system disclosed in the invention, the obtained magnetic nanoparticles have paramagnetism, superparamagetism, ferrimagnetism or ferromagnetism, and the surfaces of the magnetic nanoparticles are modified by the alkyl chain-containing micromolecules; compared with the conventional kettle type reaction, the flowing synthetic technique disclosed in the invention can greatly improve mass and heat transfer rate, so that high degree of crystallinity of product particles and narrow size distribution are achieved; and meanwhile, the flowing preparation systemcan be automatically controlled, so that the products are relatively low in difference and high in repeatability in different batches of preparation, and large-scale preparation of the nanoparticlescan be realized by continuous sampling.

Description

technical field [0001] The invention relates to the technical fields of material chemistry, nano science and fine chemical industry, in particular to a magnetic nano particle and its flow preparation method and system. Background technique [0002] Due to their unique magnetic properties, magnetic nanoparticles have been widely used in the fields of magnetic resonance imaging, drug delivery, hyperthermia, and biological separation, especially superparamagnetic iron oxide nanoparticles and gadolinium-containing paramagnetic nanoparticles in tumor diagnosis. The field shows broad prospects for clinical application. However, so far, almost all magnetic nanomaterials are synthesized by kettle (flask) reaction, not only the output is small, but also the difference between batches is large. the biggest bottleneck. [0003] As an emerging preparation method, flow synthesis provides a new option for the synthesis of nanoparticles (Angew.Chem., Int.Ed., 2010, 49, 6268; Chem.Soc.Rev...

AI Technical Summary

Problems solved by technology

Due to the complexity of the pyrolysis reaction, which not only includes the nucleation and growth process of nanoparticles, but also the thermal decomposition reaction process of the reaction precursor, the heat and mass transfer process between the reactor and the reaction liquid during the preparation process It has an extremely important impact on the size and particle size distribution of nanoparticles, and random fluctuations in reaction parameters can easily lead to unpredictable changes in particle size and particle size distribution

Images