RELEASE OF ClO2 GAS FROM MEDICAL DEVICE PACKAGING FILM

A packaging film and oxygen barrier technology, applied in packaging, wrapping paper, household packaging, etc., can solve problems such as timing is difficult to control

Inactive Publication Date: 2018-07-31
WISCONSIN ALUMNI RES FOUND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this system the ClO produced 2 The timing of is difficult to control because ClO is produced once the polymer is exposed to light, including incidental exposure to ambient visible light 2

Method used

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  • RELEASE OF ClO2 GAS FROM MEDICAL DEVICE PACKAGING FILM
  • RELEASE OF ClO2 GAS FROM MEDICAL DEVICE PACKAGING FILM
  • RELEASE OF ClO2 GAS FROM MEDICAL DEVICE PACKAGING FILM

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] Prepare 35% by weight sodium chlorite (technical grade; 80% NaClO 2 ; Sigma-Aldrich, St.Louis, MO) in water and compounded into ExxonMobil using a 50mm co-rotating twin-screw extruder 3040 resin particles (ethylene-hexene copolymer; density = 0.900g / cm 3 ; Melt Index = 17 dg / min; ExxonMobil Chemical Company, Baytown, TX). The sodium chlorite content of the resulting resin was 7.4% by weight.

[0124] The sodium chlorite-containing resin was melt-cast into a film by using a three-layer flat-die extrusion system through a melt-extrusion process. The EVOH and LDPE layers were extruded simultaneously with the sodium chlorite-containing resin using a co-extrusion process to produce a 25 cm wide three-layer sheet such that the layers were arranged as follows: 1.5 mil LDPE / 1.5 mil EVOH / 1 mil LLDPE sodium chlorite. EVA (DuPont 3124EVA) monolayer film was also produced. These do not contain sodium chlorite.

[0125] A self-sterilizing bag was made from the film by fold...

Embodiment 2

[0129]The sodium chlorite-containing resin and film were produced using the same procedure as described in Example 1 for self-sterilizing bags. The resulting film had a structure of 1.5 mil LDPE / 1.5 mil EVOH / 1.5 mil LLDPE containing sodium chlorite (16% by weight).

[0130] A self-sterilizing bag was made from the film by folding the two sides of the film sample (30 cm long, 15 cm wide) over itself and heat sealing, so that the chlorite-containing resin layer was inside. These bags were placed in a high humidity environment (35°C, 80% RH) for about 12 hours. A self-contained biological indicator (SCBI) is inserted into the pouch of interest along with a vacutainer (a small device made of rigid plastic used to take a fixed volume of blood from a patient) and heat sealed to complete the airtight package. The pouch was exposed to 254nm UV for 180 seconds. When the bag is opened, use ClO 2 Gas alarm detector to see if there is still ClO in the package 2 .

[0131] SCBI in pou...

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Abstract

A multilayer medical packaging film includes a first layer and a chlorine dioxide-producing layer. The chlorine dioxide-producing layer includes a polymer composition and a plurality of chlorite ions.The chlorine dioxide-producing layer is substantially free of an energy-activated catalyst and is substantially free of an acid-releasing compound. However, the film is capable of generating chlorinedioxide when exposed to UV light and moisture.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 206,464, filed August 18, 2015. This application is hereby incorporated by reference without conflicting with the present disclosure. technical field [0003] The present disclosure generally relates to the release of sterile gases from packaging films for medical devices. In particular, the present disclosure relates to a method for the controlled release of ClO from the packaging of medical devices. 2 Gas compositions and methods. Background technique [0004] Chlorine dioxide (ClO 2 ) is a powerful oxidizer and disinfectant. It is currently mainly used in the bleaching process of the pulp industry and as a disinfectant for water treatment. It has proven useful as a broad-spectrum fungicide in applications as diverse as food processing, fungus and mold fumigation, biofilm treatment and even killing bed bugs and hardy anthrax spore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B32B27/32
CPCB32B27/32B32B27/06B32B27/00B32B27/30B32B27/306B32B27/08B32B27/20B32B33/00B65D65/40B32B2255/26B32B2307/31B32B2307/7145B32B2439/80B32B2439/00B32B7/12B32B27/18B32B27/28B32B27/304B32B27/322B32B27/34B32B27/36B32B2264/10B32B2307/40B32B2307/50B32B2307/71B32B2307/7242B32B2307/7244B32B2307/7246B32B2307/732B32B2307/748B32B2439/06B32B2439/46B32B2439/70B32B15/08B65D1/00B32B2255/10B32B2255/20B32B2255/205B32B1/02B32B15/20B65D81/24A61L2/20A61L2202/11B32B15/082B32B15/085A23B7/144B32B2315/00B32B2323/10B32B2405/00C08L23/12C08L2203/16B01J19/123B01J2219/0879B01J2219/1203C01B11/024C08K3/24
Inventor N·阿尔伯特R·简恩K·纳尔逊D·布希D·林恩
Owner WISCONSIN ALUMNI RES FOUND
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