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Radix Aucklandiae reference extract product, and preparation method and application thereof

A technology of extract and woody incense, applied in the field of woody incense reference extract and preparation thereof, can solve the problems of difficulty in ensuring consistent quality, unable to reflect the whole picture of medicinal materials, unable to reflect the content of medicinal materials, etc., and achieve uniformity, ease of use, cost Low, stable effect

Active Publication Date: 2018-08-03
广州博奥技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, both chemical reference substances and traditional Chinese medicine reference materials have their limitations in the quality control of traditional Chinese medicine
This limitation is manifested in: 1. The chemical components in traditional Chinese medicine are diversified, and a single or a few compounds cannot reflect the whole picture of the medicinal materials, and the existing standards often have many loopholes, and the phenomenon of shoddy goods sometimes occurs; 2. Traditional Chinese medicine control materials are affected by the place of origin and growth environment, so it is difficult to ensure the quality of each batch is consistent, and it can only be used for qualitative identification, and cannot reflect the content of medicinal materials

Method used

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  • Radix Aucklandiae reference extract product, and preparation method and application thereof
  • Radix Aucklandiae reference extract product, and preparation method and application thereof
  • Radix Aucklandiae reference extract product, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] The screening of embodiment 1 woody raw medicinal material

[0084] This example provides a screening method for the raw materials of the control extract of Xanthomonas xanthus in the present invention.

[0085] Using thin layer chromatography and high performance liquid chromatography to analyze and screen the raw medicinal materials of xanthus argentina with chemical reference substances as reference substances.

[0086] The woody medicinal material is purchased from major medicinal material markets across the country, and has been identified as the dried root of the Compositae plant, Aucklandia lappaDecne. After identification, 9 batches of medicinal materials meet the standards and can be used for future use.

[0087] 1 TLC

[0088] 1.1 Sample preparation

[0089] Chemical reference solution: Accurately weigh cressyl lactone and dehydrocressine lactone, and prepare 1 mg / ml solutions with methanol.

[0090] Coriander reference extract solution: Accurately weigh 0.2...

Embodiment 2

[0124] Embodiment 2 The preparation of the woody contrast extract of the present invention

[0125] 4 batches with high similarity were selected from the raw materials screened and identified in Example 1, and the extracts of Caussia sinensis were prepared respectively.

[0126] Refer to attached image 3 flow chart of

[0127] One: extract

[0128] Select woody medicinal materials and make them into powder. The medicinal powder is passed through a No. 2 sieve (850±29 μm, 24 mesh), and then 5 times its mass volume of petroleum ether (II) is added (that is, the solid-liquid ratio is 1:5 (w / V )), ultrasonic (power 500w, normal temperature) extraction for 30min, medium-speed qualitative filter paper filtration, collecting filter residue Ⅰ 1 and filtrate I 1 , filter residue I 1 Extract again three times by the same method, and extract the filtrate collected three times again and filtrate I 1 The combination is the extract I, and the solvent of the extract I is recovered to ...

Embodiment 3

[0142] The character analysis of embodiment 3 Coriander tree contrast extract

[0143] 1. Apparent state: the Corywood reference extract that embodiment 2 obtains is yellow powder.

[0144] 2. Moisture determination: according to the 2015 edition Chinese Pharmacopoeia Appendix IX G (reduced pressure drying method). The test result shows that the water content of the control extract of Cassia sinensis is 1.51%.

[0145] 3. Consistency test: Prepare 4 batches of coriander extracts according to the method of Example 2, and the TLC detection results for corymolide and dehydrocorylide between each batch are very different Small, the fluorescent spots of coynelide and dehydrocoylidene are clearly displayed, and the distribution is very consistent; the contents of coynelide and dehydrocoylidene are all in the Within the range of deployment standards. Therefore, the consistency of the Caymania saponica reference extract prepared by the preparation method of the Caymantheca woody re...

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Abstract

The invention provides a Radix Aucklandiae reference extract product, and a preparation method and an application thereof. The preparation method comprises the following steps: respectively extractingbatches of Radix Aucklandiae medicinal material powders multiple times to obtain Radix Aucklandiae extracts in batches, and blending the Radix Aucklandiae extracts in batches to obtain the Radix Aucklandiae reference extract product. The preparation method of the Radix Aucklandiae reference extract product has the advantages of simplicity in operation, low cost, good repeatability and high extraction rate; and the Radix Aucklandiae reference extract product is prepared through the preparation method, so the consistence of the Radix Aucklandiae reference extracts in different batches is ensured, and the Radix Aucklandiae reference extract product has the advantages of stable and uniform properties, and convenience in use; the total content of costunolide and dehydrocostus lactone in the reference extract product finally obtained through the preparation method of the Radix Aucklandiae reference extract product is not less than 3.5% and not more than 9.0%, and the water content of the product is not more than 5.0%; and the thin-layer chromatography fingerprint and the HPLC fingerprint of the reference extract product are correspondingly consistent to those of a certified product Radix Aucklandiae medicinal material.

Description

technical field [0001] The invention relates to the technical field of quality control of traditional Chinese medicines, in particular to a reference extract of xanthus chinensis and its preparation method and application. Background technique [0002] The current quality control mode of traditional Chinese medicine is basically following the development of natural medicinal chemistry, with the idea of ​​analysis methods targeting one or several active ingredients of traditional Chinese medicine and quality standards that can be both qualitative and quantitative, referring to the quality of foreign herbal medicines. The control method draws on the model of chemical drug quality control, and establishes corresponding simple physical and chemical identification with the help of literature reports, and then develops to the quality standard of identification and content determination based on spectrum and chromatography. [0003] Every Chinese medicinal material is a complex of ...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/90G01N30/02
CPCG01N30/02G01N30/06G01N30/90
Inventor 许舜军陈海燕郭隆钢谢培山许铮弟张奕尧张和灿
Owner 广州博奥技术有限公司
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