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Application of steroidal compound in preparation of medicine for preventing or treating gastric ulcer and its complications

A technology of steroidal compounds and gastric ulcers, which is applied in the application field of steroidal compounds in the preparation of drugs for the prevention or treatment of gastric ulcers and its complications, and can solve the problems that the research on the anti-gastric ulcer effect and its mechanism has not yet been reported.

Active Publication Date: 2018-08-14
贵州省食品药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that Physalis bitterins have good biological activities in anti-inflammatory, antibacterial, anti-cancer and analgesic aspects, but their anti-gastric ulcer effect and its mechanism have not been reported yet.

Method used

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  • Application of steroidal compound in preparation of medicine for preventing or treating gastric ulcer and its complications
  • Application of steroidal compound in preparation of medicine for preventing or treating gastric ulcer and its complications
  • Application of steroidal compound in preparation of medicine for preventing or treating gastric ulcer and its complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0189] Process: take Physalis bitterin B 100g, mix with 50g starch and 50g dextrin powder, put into capsules, make 1000 capsules, and get ready.

[0190] Physalis bitterin B is prepared in this way: take 30kg of the whole herb of Physalis plant, crush it into a coarse powder, soak it with industrial methanol for 3 times, each time for 3 days, filter, combine the filtrates, recover the organic solvent under reduced pressure, evaporate to dryness Paste 4.18kg, add 1L 80-90°C distilled water to suspend, extract 3 times with ethyl acetate, 2 hours each time, recover the solvent, and obtain the extract of ethyl acetate part;

[0191] Separation of the extract from the ethyl acetate part by silica gel column chromatography, first dissolve the extract from the part of ethyl acetate with organic solvents such as chloroform, methanol, ethyl acetate, mix the sample, and use silica gel (200-300 mesh) to mix the solution evenly Mix, dry naturally, grind into powder for later use, pack int...

Embodiment 2

[0196] Process: take total Physalis bitterin, add water for injection to dissolve, add 2% mannitol, dry, and prepare into freeze-dried powder for injection.

[0197] Described total Physalis bitterin is; Prepare according to the following method:

[0198] (1) Take the crushed brocade lantern, add 10-15 times the amount of hydrothermal reflux extraction, and the extraction time is 1.5-2.0 hours;

[0199] (2) Concentrate the extract and add ethanol to carry out alcohol precipitation. The alcohol concentration of the solution after adding is 70%-80%. , with ethanol water as the elution solvent, elution gradient: 20%, 30%, 40%, 50%, 60%, 70%, 80%, 95% (volume ratio), collect 40%-70% ethanol wash Remove the parts, and evaporate to dryness under reduced pressure to obtain the dry total physalis extract.

[0200] Usage and dosage: intramuscular injection, intravenous injection or intravenous infusion, the daily dosage is 2-4mL.

[0201] Functions and indications: It has inhibitory...

Embodiment 3

[0203] Process: take Physalis bitterin B, add water for injection to dissolve and pot it in a corresponding container, sterilize it by hot pressing at 115°C for 30 minutes, after cooling, filter it with suction, dilute the filtrate with water for injection, filter it with a vertical melting filter ball, and pot it , 115 ° C and then autoclaved for 30 minutes, prepared as an injection.

[0204] Physalis bitterin B: the preparation method is the same as in Example 1.

[0205] Usage and dosage: intramuscular injection, intravenous injection or intravenous infusion, the daily dosage is 2-4mL.

[0206] Functions and Indications: For the treatment of gastric ulcer, gastric bleeding, gastric perforation, pyloric obstruction, duodenal ulcer or gastric cancer. embolism.

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Abstract

The invention discloses an application of a steroidal compound in the preparation of a medicine for preventing or treating gastric ulcer and its complications. The complications comprise gastrorrhagia, gastric perforation, pyloric obstruction and duodenal ulcer or stomach cancer. The steroid compound is total physalin or physalin B, and it is confirmed that the total physalin or / and the physalin Bhas / have a significant gastric ulcer treatment effect. The total physalin or the physalin B can be processed to prepare a medicinal preparation, and the medicinal preparation can be used to treat thegastric ulcer and duodenal ulcer as a novel anti-gastric ulcer medicine, and is simple and convenient to use.

Description

technical field [0001] The present invention relates to the application of steroid compounds in the preparation of medicines for preventing or treating gastric ulcer and its complications, especially the application of total physalispicrin or Physalispicrin B in the preparation of medicines for preventing or treating gastric ulcers. Background technique [0002] Gastric ulcer (GU) is a common and frequently-occurring disease, and it is also a recurring chronic gastrointestinal disease. According to relevant statistics, its incidence rate accounts for about 10% of the total population. The modern medical pathogenesis of peptic ulcer has not been fully elucidated so far. At present, it is believed that the gastric mucosal injury caused by the imbalance between attacking factors and defense factors is the direct cause of the disease. At present, internal medicine mainly uses anti-Hp drugs, antacids, gastric acid secretion inhibitors and gastric mucosal protective agents for tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61K36/81A61P1/04
CPCA61K31/585A61K36/81A61K2236/331A61K2236/53A61P1/04
Inventor 王勇张炯怡马莹宋晓宁张志勇李泽夏琼赵丽刘丹邱红燕
Owner 贵州省食品药品检验所
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