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A kind of micro-nano bioactive glass and its preparation method and application

A bioactive glass, micro-nano technology, used in glass manufacturing equipment, glass molding, manufacturing tools, etc., can solve the problems of slow formation of micelles, mutual adhesion, low production efficiency, etc. Formation rate, the effect of reducing dosage

Active Publication Date: 2019-04-05
杭州纳美智康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, although the sol-gel method in the prior art can obtain micro-nano particles with specific morphology, due to the lack of dispersion and regularity of the micellar particles, the entire sol-gel process is uncontrollable. Low production efficiency and slow formation of micelles lead to mutual adhesion during the gelation process, and the application performance of the final product obtained will also be affected to a certain extent, which limits the further application of bioactive glass

Method used

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  • A kind of micro-nano bioactive glass and its preparation method and application
  • A kind of micro-nano bioactive glass and its preparation method and application
  • A kind of micro-nano bioactive glass and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0054] The preparation method of micro-nano bioactive glass is as follows:

[0055] 1) Change [C 16 min] Br, C 12 -2-C 12 ·2Br - And Tween 80 was added into water to form a mixed solution, and the concentration of template agent was controlled at 0.03mmol / L;

[0056] 2) Then 180g of tetraethyl orthosilicate, 25g of trimethyl phosphate, 4g of polyhydroxybutyrate, 5g of polyhydroxypropionate, 75g of calcium nitrate, 9g of strontium nitrate, 6g of magnesium nitrate, 60g of potassium nitrate, 5g of citric acid , 20 g of polyethylene glycol was added to the above mixed solution, and stirred evenly to obtain a bioactive glass gel solution, and the mass ratio of the total mass of the above precursor to the template agent was controlled at 2:1;

[0057] 3) centrifuging and washing the bioactive glass gel solution to obtain a wet gel precipitate, and then drying the wet gel precipitate in a 60°C drying oven for 2 days to obtain a bioactive glass gel powder;

[0058] 4) The bioacti...

Embodiment 2

[0060] The preparation method of micro-nano bioactive glass is as follows:

[0061] 1) [C with a mass ratio of 1:1 16 min] Br, C 12 -2-C 12 ·2Br - Form a templating agent with Tween 80 ([C 16 min] Br, C 12 -2-C 12 ·2Br - The mass percentage is 30wt%, and the balance is that Tween 80 is added into water to form a mixed solution, stirred and mixed at a rate of 200rpm, and the concentration of the template agent is controlled at 0.01mmol / L;

[0062] 2) Then 200g of tetraethyl orthosilicate, 15g of trimethyl phosphate, 5g of polyhydroxybutyrate, 4g of polyhydroxypropionate, 85g of calcium nitrate, 6g of strontium nitrate, 9g of magnesium nitrate, 40g of potassium nitrate, 10g of citric acid 10g of polyethylene glycol was added to the above mixed solution, and stirred evenly to obtain a bioactive glass gel solution, and the mass ratio of the total mass of the above precursor to the template agent was controlled at 3:1;

[0063] 3) Centrifuge and wash the bioactive glass gel...

Embodiment 3

[0066] The preparation method of micro-nano bioactive glass is as follows:

[0067] 1) [C with a mass ratio of 2:1 16 min] Br, C 12 -2-C 12 ·2Br - Form a templating agent with Tween 80 ([C 16 min] Br, C 12 -2-C 12 ·2Br -The mass percentage is 40wt%, and the balance is that Tween 80 is added into water to form a mixed solution, stirred and mixed at a speed of 400rpm, and the concentration of the template agent is controlled at 0.1mmol / L;

[0068] 2) Add 190g of tetraethyl orthosilicate, 22g of trimethyl phosphate, 4.5g of polyhydroxybutyrate, and 4.8g of polyhydroxypropionate to form the first component, and then add 15g of polyethylene glycol and 77g of calcium nitrate in sequence , strontium nitrate 8g, magnesium nitrate 7g, potassium nitrate 45g, citric acid 9g are mixed into the second component;

[0069] 3) Add the above-mentioned first component and the second component into the mixed solution, stir evenly to obtain a bioactive glass gel solution, and control the ...

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Abstract

The invention provides a micro-nano bioactive glass and a preparation method and application thereof. The micro-nano bioactive glass is mainly prepared from a precursor and a template agent; the precursor is prepared from, by mass, 180-200 parts of ethyl orthosilicate, 15-25 parts of trimethyl phosphate, 4-5 parts of polyhydroxybutyrate, 4-5 parts of polyhydroxy propionate, 75-85 parts of calciumnitrate, 6-9 parts of strontium nitrate, 6-9 parts of magnesium nitrate, 40-60 parts of potassium nitrate, 5-10 parts of citric acid and 10-20 parts of polyethylene glycol; the template agent is composed of [C16min]Br, C12-2-C12 2Br<-> and tween 80. The micro-nano bioactive glass is high in biocompatibility, micelle particles which are ordered, high in dispersity and uniform in size are formed byoptimization of the precursor and the template agent formula, and micelle forming rate is remarkably increased.

Description

technical field [0001] The invention relates to the field of biological glass production, in particular to a micro-nano bioactive glass and its preparation method and application. Background technique [0002] Bioactive glass (BG) has attracted extensive attention in the fields of chemical materials and medicine due to its good biocompatibility, bioactivity, osteoconductivity and degradability. At present, bioactive glass has been successfully used in the treatment and restoration of bone injuries and dental diseases. [0003] Its composition and structure determine its inherent performance, and its performance further determines its use. Similarly, the excellent properties of BG such as biological activity mainly depend on its special composition structure. BG is generally SiO 2 -P 2 o 5 -CaO system, partially containing Na 2 O, MgO, SrO and other alkali metal or alkaline earth metal oxides. The first and most famous bioactive glass is 45S5Bioglass discovered by Larr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/25A61K8/24A61K8/19A61K8/81A61K8/86A61L27/10A61L27/12A61L27/54A61Q11/00C03B19/00C03B19/12C03C3/00C03C4/00
CPCA61K8/19A61K8/24A61K8/25A61K8/8152A61K8/86A61L27/10A61L27/12A61L27/54A61L2430/12A61Q11/00C03B19/00C03B19/12C03C3/00C03C4/0007C03C4/0021
Inventor 苏隽王德俊
Owner 杭州纳美智康科技有限公司