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Preparation method of reduced graphene oxide/bioglass nanofiber scaffold

A technology of biological glass and nanofibers, applied in tissue regeneration, pharmaceutical formulation, drug delivery, etc., can solve the problem of low chemical activity of hydroxyl groups, achieve high biological activity, high porosity, and simple preparation process

Inactive Publication Date: 2018-08-17
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low chemical activity of the hydroxyl groups on the surface of bacterial cellulose, it is generally difficult to combine with cations and other components.

Method used

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  • Preparation method of reduced graphene oxide/bioglass nanofiber scaffold
  • Preparation method of reduced graphene oxide/bioglass nanofiber scaffold
  • Preparation method of reduced graphene oxide/bioglass nanofiber scaffold

Examples

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Effect test

Embodiment 1

[0023] A preparation method for a highly bioactive nano glass fiber support, comprising the following steps:

[0024] (1) Weigh the granular bacterial cellulose (BC) block, put it in a cell wall breaking machine, add water and beat it into a slurry, and make a bacterial cellulose slurry solution with a mass concentration of 20%;

[0025] (2) Add graphene oxide with a mass ratio of 1%, put it in an ultrasonic machine for 1 h, and obtain a uniform dispersion solution of graphene oxide, raise the temperature to 100 °C, and add hydrazine hydrate solution dropwise to it for 1 h, and then carry out Centrifuge to obtain a reduced graphene oxide solution (rGO), wherein the mass ratio of graphene oxide to hydrazine hydrate solution is 1:1000;

[0026] (3) The bacterial cellulose solution in (1) and the reduced graphene oxide solution in (2) are mixed with ultrasound in a volume ratio of 10:1 to obtain a reduced graphene oxide / bacterial cellulose mixed solution (rGO / BC);

[0027] (3)...

Embodiment 2

[0030] A preparation method for a highly bioactive nano glass fiber support, comprising the following steps:

[0031] (1) Weigh the granular bacterial cellulose (BC) block, put it in a cell wall breaking machine, add water and beat it into a slurry, and make a bacterial cellulose slurry solution with a mass concentration of 20%;

[0032] (2) Add graphene oxide with a mass ratio of 1%, put it in an ultrasonic machine for 1 h, and obtain a uniform dispersion solution of graphene oxide, raise the temperature to 100 °C, and add hydrazine hydrate solution dropwise to it for 1 h, and then carry out Centrifuge to obtain a reduced graphene oxide solution (rGO), wherein the mass ratio of graphene oxide to hydrazine hydrate solution is 1:1000;

[0033] (3) The bacterial cellulose solution in (1) and the reduced graphene oxide solution in (2) are mixed with ultrasound in a volume ratio of 10:1 to obtain a reduced graphene oxide / bacterial cellulose mixed solution (rGO / BC);

[0034] (3)...

Embodiment 3

[0037] A preparation method for a highly bioactive nano glass fiber support, comprising the following steps:

[0038] (1) Weigh the granular bacterial cellulose (BC) block, put it in a cell wall breaking machine, add water and beat it into a slurry, and make a bacterial cellulose slurry solution with a mass concentration of 20%;

[0039] (2) Add graphene oxide with a mass ratio of 1%, put it in an ultrasonic machine for 1 h, and obtain a uniform dispersion solution of graphene oxide, raise the temperature to 100 °C, and add hydrazine hydrate solution dropwise to it for 1 h, and then carry out Centrifuge to obtain a reduced graphene oxide solution (rGO), wherein the mass ratio of graphene oxide to hydrazine hydrate solution is 1:1000;

[0040] (3) The bacterial cellulose solution in (1) and the reduced graphene oxide solution in (2) are mixed with ultrasound in a volume ratio of 10:1 to obtain a reduced graphene oxide / bacterial cellulose mixed solution (rGO / BC);

[0041] (3) C...

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Abstract

The invention belongs to the field of biological functional materials, and relates to a preparation method of a reduced graphene oxide / bioglass nanofiber scaffold. The method includes the steps: mixing massive bacterial cellulose and water to prepare bacterial cellulose solution; adding reduced graphene oxide solution and performing ultrasonic treatment to obtain reduced graphene oxide / bacterial cellulose mixed solution; adding corresponding calcium, silicon and phosphorus sources into the mixed solution and performing ultrasonic treatment to obtain bacterial cellulose / reduced graphene oxide / bioglass precursor solution; calcining the bacterial cellulose / reduced graphene oxide / bioglass precursor solution in argon atmosphere after freeze-drying to obtain the reduced graphene oxide / bioglass nanofiber scaffold with an antibacterial property. Formation of hydroxyapatite can be rapidly induced in an SBF (simulated body fluid) by the aid of a unique three-dimensional network structure. The technological process is simple, operation is simple and rapid, preparation cost is low, and the prepared bioglass nanofiber scaffold is high in antibacterial property and bioactivity and has a good application prospect in the field of bone transplantation and bone replacement.

Description

technical field [0001] The invention relates to the field of biological functional materials, in particular to a method for preparing a reduced graphene oxide / biological glass nanofiber scaffold. Background technique [0002] Today, with the rapid development of science and technology, organ shortage has become an increasingly serious problem due to organ failure and too few organ donors. In order to solve the organ shortage problem of patients waiting for organ donation for a long time, the field of tissue engineering proposes to replace and repair diseased tissues with substitutes, so as to improve the cure rate and quality of life of patients. Among them, bone transplantation has become the second largest transplant tissue in the world. Bone repair materials have been widely used in stomatology, orthopedic surgery and orthopedics because they can be used to repair and replace hard tissues in the human body. Due to the increasing number of patients with bone defects cause...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/12A61L27/02A61L27/56A61L27/54
CPCA61L27/025A61L27/10A61L27/12A61L27/54A61L27/56A61L2300/10A61L2300/404A61L2400/12A61L2430/02
Inventor 温翠莲洪云裘依梅罗立津吴军茹叶健霞谢秋罕
Owner FUZHOU UNIV
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