Preparation method of 1,2,3,4-benzoxatriazine-1,1(2H)-dioxide

A technology of dioxide and benzoxane, applied in the field of organic chemical synthesis, can solve the problems of intolerable functional groups, long reaction period, complicated operation procedures, etc., and achieve the effects of easy preparation and mild reaction conditions.
CN108440447AInactive Publication Date: 2018-08-24WENZHOU UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WENZHOU UNIVERSITY
Publication Date
2018-08-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of 1,2,3,4-benzoxatriazine-1,1(2H)-dioxide. The preparation method is characterized in that 2-aminobenzenesul fonamide and tert-butyl nitrite are taken asreaction materials and have a diazo-reaction in a reaction solvent to obtain 1,2,3,4-benzoxatriazine-1,1(2H)-dioxide, and the reaction temperature is 0 DEG C to 50 DEG C. The preparation method has the beneficial effects that the reaction is efficient, the yield is high, the operation is convenient, and the postprocessing is simple; an oxidizing reagent or a catalyst are not required to be added;the reaction condition is mild, the reaction is carried out at a room temperature, the 1,2,3,4-benzoxatriazine-1,1(2H)-dioxide is easy to prepare, and the reaction is green and economical.
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Description

technical field

[0001] The invention relates to a preparation method of a compound, in particular to a preparation method of 1,2,3,4-benzoxatriazine-1,1(2H)-dioxide, and belongs to the technical field of organic chemical synthesis. Background technique

[0002] 1,2,3,4-Benzoxatriazine-1,1(2H)-dioxide compounds are a kind of nitrogen-containing heterocyclic compounds, which have biological activities such as sterilization, anti-inflammation and inhibition of disordered growth of viruses , which are widely used in organic synthesis intermediates, dyes, preservatives, and are often found in the dominant structure of kinase inhibitors.

[0003] At present, the method for the synthesis of 1,2,3,4-benzoxatriazine-1,1(2H)-dioxide compounds reported in the literature mainly utilizes 2-aminobenzenesulfonamide compounds as substrates, Diazobenzene is synthesized by diazotization reaction under acidic conditions, and then the pH value of the solution is adjusted so that an intramolecu...

Claims

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