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Extraction separation method of polydatin

A separation method and technology of Polygoniside, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of complex composition, difficulty in extracting Polygonin, and many impurities, and achieve large adsorption capacity and separation. The effect is remarkable and the process is simple

Active Publication Date: 2018-08-24
云南海沣药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many impurities in the leaves and complex components. It is difficult to extract polydatin from Polygonum cuspidatum leaves. With reference to the method of extracting and separating polydatin from Polygonum cuspidatum roots, it is impossible to obtain polydatin with high purity from leaves; It is necessary to extract and separate polydatin to protect resources and improve resource utilization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Take 1 kg of dried Polygonum cuspidatum leaves, crush it to 20 mesh, add 7L ethanol-water solution (mass percentage concentration is 70%), extract at 50°C for 6 hours, filter, and add 5L ethanol-water solution (mass percentage concentration) to the filter residue again. The percentage concentration is 70%) at 50°C for 4 hours, filtered, combined with the filtrate obtained from the second filtration, the filtrate was concentrated under reduced pressure to recover ethanol, concentrated until the density of the extract was 1.15, and the extract was obtained; while stirring in the extract Add ether with 5 times its mass, continue to stir for 10 minutes after adding, let it stand for 2 hours, remove the ether layer, and repeat the extraction twice with ether with 4 times the mass of the extract, and the syrup after ether extraction evaporates. Dry remove the ether to obtain the deesterified extract; add 8 times the mass of water to the deesterified extract, heat to...

Embodiment 2

[0018] Example 2: Take 1 kg of dried Polygonum cuspidatum leaves, crush it to 30 mesh, add 6L ethanol-water solution (mass percentage concentration is 72%), extract at 55°C for 5 hours, filter, and add 5L ethanol-water solution (mass percentage concentration) to the filter residue again. The percentage concentration is 72%) at 60°C for 4 hours, filtered, combined with the filtrate obtained from the second filtration, the filtrate was concentrated under reduced pressure to recover ethanol, concentrated until the density of the extract was 1.18, and its mass 6 was added to the extract while stirring. After adding ether, continue to stir for 12 minutes, let it stand for 3 hours, remove the ether layer, and repeat the extraction of the syrup twice with 5 times the weight of the extract, and evaporate the extracted syrup to remove the ether. Add 9 times its mass of water to the extract that removes the ether, heat, boil and stir for 20 minutes, pour out the water extract, then repea...

Embodiment 3

[0019] Example 3: Take 1 kg of dried Polygonum cuspidatum leaves, crush it to 40 mesh, add 7L ethanol-water solution (mass percentage concentration is 75%), extract at 60°C for 4 hours, filter, and add 6L ethanol-water solution (mass percentage concentration) to the filter residue again. Percentage concentration is 75%) at 55 ℃ for 5 hours, after filtering, leaching once again, combining the filtrate obtained by filtering for 3 times, the filtrate is concentrated under reduced pressure to recover ethanol, concentrated until the density of the extract is 1.2, and in the extract Add ether 7 times its mass while stirring, continue to stir for 15 minutes after adding ether, let it stand for 4 hours, remove the ether layer, and repeat the extraction of the syrup with ether 6 times the mass of the extract for 3 times, the syrup after ether extraction The solid was evaporated to dryness to remove the ether; add water with 10 times the mass of the ether-removed extract, heat, boil and ...

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PUM

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Abstract

The invention discloses an extraction separation method of polydatin. According to the method, polygonum cuspidatum leaves are adopted as the raw materials, technology procedures including alcohol extraction, degreasing in diethyl ether, water solution for filtering, resin column chromatography isolation and the like are adopted, and polydatin the content of which reaches 70% or above is prepared;the separation effect is remarkable, and a product the content of which reaches 98% or above can be obtained after simple recrystallization. The process of the method is simple, the recovery rate ishigh, the purity is high, and the method is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting and isolating polydatin from Polygonum cuspidatum leaves, belonging to the field of compound separation. Background technique [0002] Polydatin, also known as Polydatin, is mainly derived from the dry rhizome and root of Polygonum cuspidatum. Its chemical name is 3,4'-5-Trihydroxystilbene-3-beta-D-glucopyranoside, and its chemical structure is as follows: Shown in formula I; polydatin is a natural active ingredient, polydatin has the effects of antitussive, expectorant, asthma, antibacterial, free radical scavenging, blood lipid regulation, and cholesterol lowering. Because it can inhibit the release of lysosomal enzymes, it has inhibitory effects on Staphylococcus aureus, catarrhal bacteria, type A or type B streptococcus, Escherichia coli, etc. Improve microcirculation, prevent white blood cells from sticking in microcirculation, lower blood lipids, and resist lipid peroxidation, thereby affecting th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/203C07H1/08
CPCC07H1/08C07H15/203
Inventor 杨丽梅郭占伟杨杰陈谷林
Owner 云南海沣药业有限公司
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