Composite preparation for improving SCFA producing strains in intestinal tract, and preparation method and application thereof

A compound preparation and bacteria-producing technology, which is applied in the field of oral preparations, can solve the problems of large appetite, intestinal flora imbalance, and promotion of obesity, and achieve the effect of good safety, simple process, and effective regulation of intestinal flora

Active Publication Date: 2018-09-25
MEI YI TIAN BIOLOGICAL MEDICINE WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition, long-term intake of high-fat foods will lead to intestinal flora imbalance, resulting in higher levels of acetic acid in the intestines. This positive regulatory mechanism makes food intake larger and larger, thereby promoting obesity and insulin resistance.

Method used

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  • Composite preparation for improving SCFA producing strains in intestinal tract, and preparation method and application thereof
  • Composite preparation for improving SCFA producing strains in intestinal tract, and preparation method and application thereof
  • Composite preparation for improving SCFA producing strains in intestinal tract, and preparation method and application thereof

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preparation example Construction

[0040] The embodiment of the present invention provides a method for preparing the above-mentioned compound preparation for improving SCFA-producing bacteria in the intestinal tract, which includes the following steps:

[0041] It is obtained by mixing and grinding oligosaccharides, plant extracts, fungal extracts, sodium taurate and astragalus extracts.

[0042] Among them, the plant extract can be purchased as a high-purity extract, or can be prepared according to the following preparation method:

[0043] Wash and grind the selected plant materials, mix them, add 4-6 times the weight of hot water at 60°C-80°C for 3-4 hours, filter to obtain the extract; concentrate the extract, and then use ethanol precipitation to obtain the crude polysaccharide ; The crude polysaccharide is separated by chromatography and eluted with distilled water to obtain a polysaccharide liquid; after the polysaccharide liquid is concentrated, it is precipitated with ethanol and dried to obtain a pow...

Embodiment 1

[0065] The present embodiment provides a kind of composite preparation, and it is to adopt following preparation method to make:

[0066] Prepare raw materials: 630g oligosaccharides (100g inulin, 100g fructooligosaccharides, 100g xylooligosaccharides, 90g galactooligosaccharides, 50g isomaltooligosaccharides, 50g polydextrose, 50g resistant dextrin, 50gL arabinose and 40g Konjac glucomannan); 230g plant extracts (50g kombu extract, 80g sealwort extract, 50g poria cocos extract, 50g wolfberry extract); 120g fungal extracts (60g shiitake mushroom extract, 40g cordyceps extract, 20g yeast extract); 10 g sodium taurate; and 10 g Astragalus extract.

[0067] The above-mentioned oligosaccharides, plant extracts, fungal extracts, sodium taurine and astragalus extracts are mixed and ground to obtain the product.

Embodiment 2

[0069] The present embodiment provides a kind of composite preparation, and it is to adopt following preparation method to make:

[0070] Prepare raw materials: 220g oligosaccharides (50g galactooligosaccharides, 50g isomaltooligosaccharides, 50g polydextrose, 50gL arabinose and 20g konjac glucomannan); 430g plant extracts (100g kelp extract, 80g sealwort extract , 100g Poria cocos extract, 100g wolfberry extract, 20g Pueraria flavonoids and 30g ginseng extract); 300g fungal extract (100g shiitake mushroom extract, 50g Cordyceps extract, 100g Hericium erinaceus extract and 50g yeast extract); 25g Sodium taurine; and 25g of Astragalus extract, 10g of Dendrobium officinale extract.

[0071] The above-mentioned oligosaccharides, plant extracts, fungal extracts, sodium taurine, extracts of astragalus and dendrobium officinale extracts are mixed and ground to obtain the product.

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Abstract

The invention relates to a composite preparation for improving SCFA producing strains in the intestinal tract, and a preparation method and application thereof, and relates to the field of oral preparations. The composite preparation in the embodiment of the invention is prepared from the following raw materials in percentage by mass: 22%-63% of oligosaccharide, 22%-43% of a plant extract, 10%-30%of a fungal extract, 0.5%-5% of sodium taurate and 0.5%-5% of a radix aastragali extract. The composite preparation is safe and can effectively regulate intestinal flora. The preparation method of the composite preparation comprises the steps of mixing and grinding the oligosaccharide, the plant extract, the fungal extract, the sodium taurine and the radix aastragali extract. The process is simple and facilitates industrialized production. The composite preparation can be used to prepare an oral preparation for reducing the ratio of Phylum Firmicutes / Bacteroides in the intestinal tract and increasing the proportion of the SCFA producing strains.

Description

technical field [0001] The invention relates to the field of oral preparations, and in particular to a compound preparation for increasing SCFA-producing bacteria in the intestinal tract, a preparation method and application. Background technique [0002] Studies have shown that changes in the intestinal flora in the human body can lead to obesity. The mechanism is: high-calorie food enters the intestinal tract after being chewed by the teeth and initially degraded by the stomach, and the microorganisms living in the intestinal tract are responsible for the remaining digestion Work; during the fermentation process of microorganisms, a large amount of acetate will be produced, and these acetates will be absorbed by the intestines, pass through the blood-brain barrier with the blood circulation, and enter the brain; the acetates entering the brain will activate the parasympathetic nervous system . The parasympathetic nerve activated by acetate will send instructions to the pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K36/8984A61K9/00A61P3/04A61K31/185A61K31/733A61K31/702A61K31/716A61K31/718A61K31/736A61K31/7004
CPCA61K9/0053A61K31/185A61K31/7004A61K31/702A61K31/716A61K31/718A61K31/733A61K31/736A61K36/02A61K36/03A61K36/064A61K36/068A61K36/07A61K36/076A61K36/258A61K36/481A61K36/488A61K36/65A61K36/68A61K36/71A61K36/815A61K36/8969A61K36/8984A61P3/04A61K2300/00
Inventor 沈鹤霄李国龙
Owner MEI YI TIAN BIOLOGICAL MEDICINE WUHAN CO LTD
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