Three-dimensional nanofiber sponge adsorption material and preparation method for adsorbing bacterial endotoxin

A bacterial endotoxin and three-dimensional nanotechnology, applied in chemical instruments and methods, other chemical processes, biological water/sewage treatment, etc., can solve the problems of plasma protein loss and high price, and achieve less flow cycle time, low cost, The effect of many adsorption sites

Active Publication Date: 2021-03-30
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, PMX-F is expensive, and most patients cannot afford the high cost of treatment; in addition, PMX-F has a compact structure, which will cause a large loss of plasma proteins while removing bacterial endotoxins

Method used

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  • Three-dimensional nanofiber sponge adsorption material and preparation method for adsorbing bacterial endotoxin
  • Three-dimensional nanofiber sponge adsorption material and preparation method for adsorbing bacterial endotoxin

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Such as figure 1 As shown, a three-dimensional nanofiber sponge adsorption material for adsorbing bacterial endotoxin, the three-dimensional nanofiber sponge adsorption material includes modified functional polyacrylonitrile nanofiber 1 and silica nanofiber 2, two A kind of nanofiber is evenly distributed, and polymyxin B3 is evenly modified on the functional polyacrylonitrile nanofiber;

[0037] The surface of the modified functional polyacrylonitrile nanofibers is covered with a large number of carboxyl groups, which can increase the amount of polymyxin B immobilized by the functional polyacrylonitrile nanofibers.

[0038] The functional polyacrylonitrile nanofiber is prepared by sequentially performing sodium hydroxide oxidation and hydrochloric acid protonation modification on the polyacrylonitrile nanofiber. Both polyacrylonitrile nanofibers and silica nanofibers can be prepared by electrospinning, and the nanofibers prepared by electrospinning have a small diamet...

Embodiment 2

[0043]A three-dimensional nanofiber sponge adsorption material for adsorbing bacterial endotoxin, the three-dimensional nanofiber sponge adsorption material includes modified functional polyacrylonitrile nanofibers and silica nanofibers, and the two nanofibers are evenly distributed , polymyxin B is evenly modified on the functional polyacrylonitrile nanofiber;

[0044] The surface of the modified functional polyacrylonitrile nanofibers is covered with a large number of carboxyl groups, which can increase the amount of polymyxin B immobilized by the functional polyacrylonitrile nanofibers.

[0045] The functional polyacrylonitrile nanofiber is prepared by sequentially performing sodium hydroxide oxidation and hydrochloric acid protonation modification on the polyacrylonitrile nanofiber. Both polyacrylonitrile nanofibers and silica nanofibers can be prepared by electrospinning.

[0046] In the three-dimensional nanofiber sponge adsorption material, the mass ratio of the functi...

Embodiment 3

[0050] A three-dimensional nanofiber sponge adsorption material for adsorbing bacterial endotoxin, the three-dimensional nanofiber sponge adsorption material includes modified functional polyacrylonitrile nanofibers and silica nanofibers, and the two nanofibers are evenly distributed , polymyxin B is evenly modified on the functional polyacrylonitrile nanofiber;

[0051] The surface of the modified functional polyacrylonitrile nanofibers is covered with a large number of carboxyl groups, which can increase the amount of polymyxin B immobilized by the functional polyacrylonitrile nanofibers.

[0052] The functional polyacrylonitrile nanofiber is prepared by sequentially performing sodium hydroxide oxidation and hydrochloric acid protonation modification on the polyacrylonitrile nanofiber. Both polyacrylonitrile nanofibers and silica nanofibers can be prepared by electrospinning.

[0053] In the three-dimensional nanofiber sponge adsorption material, the mass ratio of the funct...

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Abstract

The invention mainly belongs to the technical field of biomedical materials, and particularly relates to a three-dimensional nano fiber sponge adsorbing material for adsorbing bacterial lipopolysaccharide and a preparation method of the adsorbing material. The three-dimensional nano fiber sponge adsorbing material is composed of uniformly-distributed modified functional polyacrylonitrile nano fibers and silicon dioxide nano fibers, and the three-dimensional nano fiber sponge adsorbing material is uniformly modified with polymyxin B. The three-dimensional nano fiber sponge adsorbing material provided by the invention has a large specific surface area, high porosity, a plurality of adsorption sites, and strong adsorption selectivity and a high adsorption rate to the bacterial lipopolysaccharide.

Description

technical field [0001] The invention mainly belongs to the technical field of biomedical materials, and in particular relates to a three-dimensional nanofiber sponge adsorption material for adsorbing bacterial endotoxin and a preparation method thereof. Background technique [0002] Bacterial endotoxin, also known as lipopolysaccharide (LPS), widely exists in nature, and together with proteins and phospholipids, constitutes the outer membrane of Gram-negative bacteria. Endotoxin is composed of lipid A, core polysaccharide and O-specific polysaccharide chain 3 parts, showing hydrophilic and hydrophobic properties. Endotoxin has strong thermal stability, and its biological activity will not be destroyed unless it is kept at 160°C for at least 2 hours. When endotoxin enters the blood, there will be adverse reactions such as fever, tachycardia, leukopenia, bone marrow necrosis, hypotension, disseminated intravascular coagulation (DIC), and even sepsis. Endotoxin stimulates mon...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30C02F3/34
CPCB01J20/103B01J20/24B01J20/265B01J20/28045C02F3/34
Inventor 温永强黄垚袁志鹏
Owner UNIV OF SCI & TECH BEIJING
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