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Application of gold nanoclusters in the preparation of drugs for the treatment of tumors

A technology of gold nanoclusters and tumor drugs, which is applied in the field of biomedicine, can solve problems such as no gold nanoclusters, and achieve clear pharmacokinetics, high safety, and clear mechanism of action

Active Publication Date: 2020-08-21
INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, there is no report in the prior art that gold nanoclusters can be directly used in two-photon photodynamic tumor therapy

Method used

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  • Application of gold nanoclusters in the preparation of drugs for the treatment of tumors
  • Application of gold nanoclusters in the preparation of drugs for the treatment of tumors
  • Application of gold nanoclusters in the preparation of drugs for the treatment of tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This example takes AuNCs@DHLA as an example to illustrate its killing effect on tumor cells.

[0029] 1. Experimental materials:

[0030] 1. Experimental drugs

[0031] Chlorauric acid (Chloroauric acid, HAuCl 4 4H 2 O, gold content ≥ 47.8%), sodium borohydride (Sodiumborohydride, NaHB 4 , 98%) were purchased from Aladdin Reagent Co., Ltd. Sodium hydroxide (Sodiumhydroxide, NaOH, 97%), methanol (Methanol, 99%), absolute ethanol (Ethanol, C 2 h 5 OH), hydrochloric acid (Hydrochloric acid, HCl, 36.5%) were purchased from Beijing Chemical Reagent Company. Protease digestion solution (Tyrisin, 0.25%), phosphate buffer saline (PBS, pH 7.4) were purchased from Hyclone Company. Penicillin-Streptomycin solution (Penicillin-Streptomycin), DMEM cell culture medium (Dulbecco's modified Eagle medium) were purchased from Invitrogen. Rhodamine 6G (Rhodamine 6G, 95%) was purchased from Shanghai Jingchun Industrial Co., Ltd. Dimethylsulfoxide (Dimethylsulfoxide, DMSO, 99.7%) w...

Embodiment 2

[0049] Referring to Example 1, gold nanoclusters (AuNCs@MUA) protected by mercaptoundecanoic acid (MUA) were prepared. Also referring to Example 1, photodynamic therapy was performed on tumor-bearing nude mice. The test results showed that under light conditions, AuNCs@MUA had obvious tumor killing effect, and its tumor inhibition efficiency could reach 83%.

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Abstract

The invention belongs to the field of biomedicine and particularly discloses the application of gold nanocluster in preparation of a drug for treating tumors. Experimental study discovers that the gold nanocluster can enter cells by virtue of receptor-mediated endocytosis, form endosome and fuse with lysosome so as to deposit in the lysosome. Under light conditions, a photo chemical reaction is carried out on the surface of the gold nanocluster, production of reactive oxide species (ROS) is triggered, apoptosis is initiated, and the ROS can further attack cytoskeleton to cause cytoskeleton fracture and functional damage. The invention firstly proposes that the gold nanocluster can serve as a novel nano-drug to be used for treatment of tumors. As the nano-drug, the gold nanocluster is excellent in biocompatibility and high in safety. As an inert metal, the gold has excellent biocompatibility, and small interference on normal physiological activities of organisms / cells and low toxicity;the gold nanocluster has an effect of killing the tumors under specified conditions only, and is high in using safety.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of gold nanoclusters in the preparation of drugs for treating tumors. Background technique [0002] Gold nanoclusters (Au NCs) are nanoparticles (Au NPs) with a particle size of less than 2nm, usually composed of a few to dozens of gold atoms, and their arrangement is more like atoms, so they are often considered " Artificial atom". Since the free electrons in Au NCs are confined in a small space and cannot move freely, they exhibit obvious quantum confinement effect, which is the essence of their characteristics. [0003] Au NCs have significant Coulomb blocking effect and special magnetic properties, and the electronic structure similar to semiconductors also makes it have special fluorescence properties. The coordinative unsaturated atoms on the surface of Au NCs endow Au NCs with high catalytic activity. Therefore, Au NCs have been widely used in biol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/20A61P35/00B82Y5/00
CPCA61K9/5123A61K41/008A61P35/00B82Y5/00
Inventor 韩荣成降雨强沙印林
Owner INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI
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