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Preparation method of hydrophilic antibacterial silicon rubber medical dressings

A silicone rubber and hydrophilic technology, which is applied in the field of preparation of hydrophilic antibacterial silicone rubber medical dressings, can solve the problems of easy penetration of bacteria, dehydration of wound surface, easy adhesion of wounds, etc., to improve hydrophilicity and antibacterial properties , improve dispersion, promote healing effect

Active Publication Date: 2018-10-16
唐山尚创医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional dressings will cause dehydration of the wound surface during use, bacteria can easily penetrate, and it is easy to stick to the wound.
Therefore, modern dressings are more widely used, but the modern dressings currently used have high preparation costs, poor air permeability, and poor functionality.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of hydrophilic antibacterial silicone rubber medical dressing, comprising the following steps:

[0025] (1) Adopt the sol-gel method to make the cyclohexane sol containing titanium; Then chitosan is dissolved in deionized water to make the chitosan solution that mass concentration is 7%, and the chitosan solution that makes is slowly Add it dropwise into the above-prepared titanium-containing cyclohexane sol, stir while adding it, and continue to stir at a speed of 800 rpm for 30 minutes after the dropwise addition is completed, and obtain chitosan-coated nano A mixed solution of titanium oxide; wherein, the mass ratio of chitosan and nano titanium oxide is 1.33:1;

[0026] (2) Silicone rubber is treated with plasma to obtain activated silicone rubber;

[0027] (3) Add the above-mentioned activated silicone rubber to the ethanol solution of silane coupling agent for surface treatment, then place the surface-treated silicone rubber in the aqueous so...

Embodiment 2

[0030] A preparation method of hydrophilic antibacterial silicone rubber medical dressing, comprising the following steps:

[0031] (1) Adopt the sol-gel method to make the cyclohexane sol containing titanium; Then chitosan is dissolved in deionized water to make the chitosan solution that mass concentration is 22%, and the chitosan solution that makes is slowly Add it dropwise into the titanium-containing cyclohexane sol prepared above, stir while adding, continue to stir at a speed of 1500 rpm for 30 minutes after the dropwise addition, and obtain chitosan-coated nano A mixed solution of titanium oxide; wherein, the mass ratio of chitosan and nano titanium oxide is 2.06:1;

[0032] (2) Silicone rubber is treated with plasma to obtain activated silicone rubber;

[0033] (3) Add the activated silicone rubber prepared above to the ethanol solution of silane coupling agent for surface treatment, then place the surface-treated silicone rubber in the aqueous solution of succinic ...

Embodiment 3

[0036] A preparation method of hydrophilic antibacterial silicone rubber medical dressing, comprising the following steps:

[0037] (1) Adopt the sol-gel method to make the cyclohexane sol containing titanium; Then chitosan is dissolved in deionized water to make the chitosan solution that mass concentration is 10%, and the chitosan solution that makes is slowly Add dropwise into the titanium-containing cyclohexane sol prepared above, stir while adding dropwise, continue stirring at a speed of 900 rpm for 30 min after the dropwise addition, and obtain chitosan-coated nano A mixed solution of titanium oxide; wherein, the mass ratio of chitosan and nano titanium oxide is 1.53:1;

[0038] (2) Silicone rubber is treated with plasma to obtain activated silicone rubber;

[0039] (3) Add the above-mentioned activated silicone rubber to the ethanol solution of silane coupling agent for surface treatment, then place the surface-treated silicone rubber in the aqueous solution of succin...

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PUM

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Abstract

The invention discloses a preparation method of hydrophilic antibacterial silicon rubber medical dressings. The preparation method particularly comprises the following steps: firstly, preparing chitosan coated nanometer titanium oxide mixed liquid and preparing activated silicon rubber through plasma treatment; adding the activated silicon rubber into an ethanol solution of a silane coupling agentto perform treatment, and then putting into an aqueous solution of succinic acid diimide to perform stirring treatment to prepare surface modified silicon rubber; putting the surface modified siliconrubber into the chitosan coated nanometer titanium oxide mixed liquid to perform ultrasonic treatment, taking out and drying to prepare the medical dressings. The medical dressings prepared accordingto the method have high hydrophilic performance, can effectively promote healing of a wound and the healing quality, has excellent antibacterial property, and is simple to prepare and low in preparation cost.

Description

Technical field: [0001] The invention relates to the field of medical materials, in particular to a method for preparing a hydrophilic antibacterial silicone rubber medical dressing. Background technique: [0002] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. The market for medical dressings at home and abroad is very huge. There are tens of millions of people in China who suffer from skin injuries every year due to accidents or surgeries. The use of dressings has greatly increased. [0003] Today's dressings are roughly divided into two categories, namely traditional dressings and modern dressings. Traditional dressings are traditional gauze, while modern dressings are further divided into synthetic fiber dressings, polymer film dressings and foaming polymer dressings. However, during use of traditional dressin...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61L15/18A61L15/28A61L15/30A61L15/46
CPCA61L15/18A61L15/28A61L15/30A61L15/46A61L26/0004A61L26/0019A61L26/0023A61L26/0066A61L2300/102A61L2300/404C08L5/08
Inventor 陈东进
Owner 唐山尚创医疗科技有限公司