KGM modified lecithin loaded NADH transdermal ethosome and preparation, as well as preparation process and application thereof

Abstract

The invention discloses a KGM modified lecithin loaded NADH transdermal ethosome, belonging to the technical field of medicinal preparation production. The ethosome is prepared from the following components by weight percent: 1.05-1 percent of NADH, 0.03-10 percent of konjac glucomannan, 1-10 percent of phospholipids, 0.02-1 percent of cholesterol, 0.1-0.5 percent of a stabilizing agent, 0-1 percent of an antioxidant, 5-50 percent of low molecular weight alcohol and the balance of water. The ethosome can be used for solving the problems that NADH is easily enzymolysed, has short biological half-life period and poor stability, has a novel multi-cell vesicle structure having a spherical or spheroidal shape, has more stable thermodynamic property, smaller grain size and higher encapsulation efficiency, has more rapid and stronger transdermal performance and skin tolerance, so that the dosage can be reduced, occurrence of adverse reaction can be reduced, and safety can be improved. The invention further discloses gel containing the ethosome and a preparation process of the ethosome and gel. The gel has fine texture and good human body absorption, and the preparation process is simple,has mild condition, and is suitable for industrial volume production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparation production, and in particular relates to a KGM-modified lecithin-loaded NADH transdermal ethosome, a preparation, a preparation process and application thereof. Background technique [0002] The transdermal drug delivery system refers to a new dosage form that is administered on the skin surface, and the drug penetrates through each layer of the skin at a certain speed, and enters the blood circulation of the whole body of the human body from the capillaries to achieve an effective blood drug concentration and achieve systemic or local therapeutic effects. Compared with oral and intravenous injection, transdermal drug absorption is not affected by pH, food, transit time and other factors in the digestive tract, so it can avoid the liver and gastrointestinal first-pass effect and reduce the fluctuation of blood drug concentration , avoid drug stimulation to the gastrointestinal t...

AI Technical Summary

Problems solved by technology

However, its potential application is limited due to its poor stability at room temperature, short biological half-life, easy enzymatic degradation, and immunogenicity.

[0006] At present, NADH has a variety of administration methods, such as oral, injection, etc., but due to the nature of the drug itself, it inevitably leads to the disadvantage of frequent administration

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