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Pre-mixed strontium silicate-based biological hydraulic cementing paste composition as well as preparation method and application thereof

A strontium silicate-based and cement technology, which is applied in the field of medicine, can solve the problems of insufficient strength and brittleness of calcium phosphate bone cement, and achieves the effects of insignificant heating of the reaction, short setting time, and convenience for doctors to operate.

Active Publication Date: 2018-11-02
BEIJING C ROOT DENTAL MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the calcium phosphate bone cement is not strong enough and easy to break

Method used

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  • Pre-mixed strontium silicate-based biological hydraulic cementing paste composition as well as preparation method and application thereof
  • Pre-mixed strontium silicate-based biological hydraulic cementing paste composition as well as preparation method and application thereof
  • Pre-mixed strontium silicate-based biological hydraulic cementing paste composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of Example 1 Suspension Stable Premixed Strontium Silicate-based Cement Paste

[0037] (1) Take each raw material according to the following weight percentages:

[0038] Component (a): 55% tristrontium silicate;

[0039] Component (b): polyethylene glycol 22%;

[0040] Component (c): Zirconia 23%.

[0041] (2) Put the components (a), (c) and (b) of step (1) into a glass container in turn, mechanically mix with a stainless steel stirring rod, and fully reconcile for 10 minutes;

[0042] (3) Afterwards, the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed strontium silicate-based cement paste with stable suspension.

[0043] The material remains fluid under sealed conditions. Extruded samples are placed in a constant temperature and humidity chamber at 37°C and a humidity above 95% (or filled until the teeth are exposed to physiological fluids), hydration solidifies and hardens, hydration solidifies...

Embodiment 2

[0045]Preparation of Example 2 Suspension Stable Premixed Strontium Silicate-based Cement Paste

[0046] (1) Take each raw material according to the following weight percentages:

[0047] Component (a): Tristrontium silicate 18%;

[0048] Component (b): polyethylene glycol 27%;

[0049] Component (c): tantalum oxide 30%;

[0050] Component (d): anhydrous calcium dihydrogen phosphate 16%, tetracalcium phosphate 9%.

[0051] (2) Put the components (a), (c), (d) and (b) of step (1) into a glass container in turn, mechanically mix with a stainless steel stirring rod, and fully reconcile for 10 minutes;

[0052] (3) Afterwards, the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed strontium silicate-based cement paste 2 with stable suspension.

[0053] The material remains fluid under sealed conditions, and the extrusion sample is placed in a constant temperature and humidity chamber at 37°C and a humidity above 95% (or ...

Embodiment 3

[0054] Example 3 Preparation of Suspension Stable Premixed Strontium Silicate-based Cement Paste

[0055] (1) Take each raw material according to the following weight percentages:

[0056] Component (a): 12% tristrontium silicate, 7% distrontium silicate;

[0057] Component (b): glycerin 29%;

[0058] Component (c): bismuth trioxide 32%.

[0059] Component (d): calcium dihydrogen phosphate 20%;

[0060] (2) Put the components (a), (c), (d) and (b) of step (1) into a glass container in turn, mechanically mix with a stainless steel stirring rod, and fully reconcile for 10 minutes;

[0061] (3) Afterwards, the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a premixed strontium silicate-based cement paste 3 with stable suspension.

[0062] The material remains fluid under sealed conditions. Extruded samples are placed in a constant temperature and humidity chamber at 37°C and a humidity above 95% (or filled until the teeth are ...

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Abstract

The invention discloses a pre-mixed strontium silicate-based biological hydraulic cementing paste composition as well as a preparation method and application thereof. The pre-mixed strontium silicate-based biological hydraulic cementing paste takes strontium silicate as a main phase, and is prepared from at least one non-aqueous solvent which can be miscible with water; preferably, the pre-mixed strontium silicate-based biological hydraulic cementing paste is also prepared from at least one calcium phosphate compound and at least one radiopaque material and thereby has excellent injectable property. The material maintains fluid under sealing conditions and carries out hydration solidification hardening after being placed in a physiological environment to contact with physiological body fluid. According to the preparation method disclosed by the invention, by utilizing excellent biocompatibility and bioactivity of a strontium silicate-based material, the strontium silicate-based material is prepared into the pre-mixed strontium silicate-based cementing paste which can be used for medicine and dental dentistry, wherein the dental application relates to the fields of pulp capping, root canal therapy, dental repair and the like.

Description

technical field [0001] The present invention relates to hydraulic cement pastes for biomedical use, and more particularly to biologically hydraulic premixed strontium silicate-based pastes for orthopedic, dental and orthopedic use. Solid powder paste composition and its preparation method and application. The invention belongs to the technical field of medicine. Background technique [0002] It is well known that strontium silicate, calcium silicate can hydrate when mixed with water, and set and harden by precipitating colloidal strontium silicate, calcium silicate hydrate (Sr-S-H, C-S-H), which is different from ordinary Portland cement (OPC) similar; [0003] These silicate-based biocement materials have good uses in the field of biomedicine, especially as dental filling materials in clinical dentistry, and have been widely used. An ideal dental filling material must have good biocompatibility, antibacterial properties and clinical operability. In addition, biological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/50A61L27/52A61K6/033A61K6/06A61K6/02A61K6/00A61K6/838
CPCA61L27/025A61L27/12A61L27/50A61L27/52A61L2400/06A61L2430/02A61K6/80A61K6/838A61K6/54A61K6/853A61L2430/12A61L27/10
Inventor 吴秉民
Owner BEIJING C ROOT DENTAL MEDICAL DEVICES CO LTD
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