A kind of preparation method and application of urease gel microspheres used as urea scavenger
A technology of gel microspheres and scavengers, applied in biochemical equipment and methods, medical preparations containing non-active ingredients, medical preparations containing active ingredients, etc., to achieve uniform size, good safety, and good reusability Effect
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Embodiment 1
[0050] A preparation method for urease gel microspheres used as a urea scavenger, comprising the following steps:
[0051] 1. Take 9 parts of polyethersulfone and 90 parts of N,N-dimethylacetamide and mix them mechanically until the polyethersulfone is completely dissolved to obtain a mixed solution. Add 2 parts of acrylic acid and 0.15 parts of N- Vinylpyrrolidone, 0.03 part of initiator azobisisobutyronitrile (AIBN), 0.2 part of cross-linking agent N,N'-methylenebisacrylamide (MBA) to obtain a mixture; the above mixture is deoxygenated under nitrogen atmosphere 30min; then placed in an oil bath at 70°C under nitrogen atmosphere, with continuous mechanical stirring, reacted for 24h, then exposed to air to terminate the reaction, and finally a clear slightly yellow polymer solution was obtained.
[0052] 2. Transfer the polymer solution prepared above to a 10mL syringe, install the electrostatic ball spraying device, and through the action of voltage, make the polymer solution...
Embodiment 2
[0056] A preparation method of urease gel microspheres used as a urea scavenger, the preparation method consists of the following steps:
[0057] A. Preparation of polymer solution: using acrylic acid and N-vinylpyrrolidone as monomers, and in-situ cross-linking with polyethersulfone to prepare a polymer solution; the raw materials for preparing the polymer solution in the step A are as follows in parts by weight Component composition: 6 parts of polyethersulfone; 2 parts of acrylic acid; 0.3 part of N-vinylpyrrolidone; 0.02 part of initiator; 0.2 part of crosslinking agent and 86 parts of solvent; Polyethersulfone is dissolved in a solvent, and then acrylic acid, N-vinylpyrrolidone, initiator and crosslinking agent are added to the above polyethersulfone solution to form a reaction raw material solution; A2, the reaction raw material solution is placed in a nitrogen atmosphere After reacting for 24 hours at a constant temperature of 70° C. in an oil bath, a reaction solution ...
Embodiment 3
[0064] The difference between this example and Example 2 is that: the raw materials for preparing the polymer solution in the step A are composed of the following components in parts by weight: 12 parts of polyethersulfone; 2 parts of acrylic acid; 0.3 parts of N-vinylpyrrolidone; 0.02 part of initiator; 0.2 part of crosslinking agent and 92 parts of solvent; all the other are the same as Example 2.
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