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Compound antipyretic-analgesic and anti-inflammatory drug composition preparation for livestock and application thereof

An antipyretic, analgesic and anti-inflammatory drug technology, applied in the directions of anti-inflammatory agents, drug combinations, antipyretic drugs, etc., can solve the problems of poor curative effect, insignificant cardiovascular protection effect, and complicated traditional Chinese medicine ingredients, and achieves a simple production process. , reducing the risk of cardiovascular and gastrointestinal bleeding, the effect of reducing the risk of cardiovascular and gastrointestinal bleeding

Active Publication Date: 2018-11-13
四川吉星动物药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When used in combination, the addition of misoprostol and proton pump inhibitors is recommended in the principles of NSAIDs medication; sulfalose is also a common gastric mucosal protective agent, but the above combination can only alleviate gastrointestinal adverse reactions , but the cardiovascular protective effect is not obvious
The addition of a series of traditional Chinese medicine ingredients can reduce gastrointestinal and cardiovascular adverse reactions at the same time. However, most of the traditional Chinese medicine ingredients in the formula are complicated and have poor efficacy. Therefore, it is necessary to find a good compatibility with NSAIDs, reduce adverse reactions, and even play a synergistic effect. Traditional Chinese medicine monomers or Chinese medicine compositions with simple and clear ingredients are very necessary

Method used

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  • Compound antipyretic-analgesic and anti-inflammatory drug composition preparation for livestock and application thereof
  • Compound antipyretic-analgesic and anti-inflammatory drug composition preparation for livestock and application thereof
  • Compound antipyretic-analgesic and anti-inflammatory drug composition preparation for livestock and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-8

[0056] The raw materials honeysuckle extract and silver yellow extract used in the examples were purchased from Guanghan Sanxingdui Biotechnology Co., Ltd.

[0057] The prescription (5 mL) of a veterinary compound antipyretic, analgesic and anti-inflammatory drug composition preparation injection of the present invention is .

[0058] Table 1. Example 1-8 formulations.

[0059]

[0060] Note: (1) The amount of silver yellow extract is calculated by chlorogenic acid, where chlorogenic acid:baicalin=10:1-1:100;

[0061] (2) q.s. means appropriate amount and sufficient amount.

[0062] The preparation method includes the following steps.

[0063] Take the prescription amount of Scutellaria baicalensis extract (calculated as baicalin) and add it to the injection solvent containing pH regulator buffer to disperse, adjust the pH value to 6.5, boil for 3 minutes, and the temperature of the filtrate drops below 60°C, then add the honeysuckle extract ( Calculated as chlorogenic...

Embodiment 9

[0065] Study on the preparation stability of veterinary compound antipyretic, analgesic and anti-inflammatory drug composition injection.

[0066] 1. Experimental method: Take the prescription amount of Scutellaria baicalensis extract (calculated as baicalin) and add it to the injection solvent containing pH regulator buffer to disperse, adjust the pH value to 6.5, boil for 3 minutes, and the temperature of the filtrate drops below 60°C, and then Add honeysuckle extract (calculated as chlorogenic acid), after the dissolution is complete, adjust the value to 7.0 with 8% sodium hydroxide solution, settle overnight, and filter to obtain liquid A. Add the prescribed amount of flunixin meglumine, diclofenac sodium, ibuprofen, indomethacin, meloxicam, nimesulide, analgin or antipyrine into the injection solvent to disperse, stir to dissolve, Use 1mol / L hydrochloric acid to adjust the pH to 7.0, which is B solution. Add liquid A slowly to liquid B which is stirring, and adjust the p...

Embodiment 10-19

[0074] The prescription (powder, 100 g) of a veterinary compound antipyretic, analgesic and anti-inflammatory drug composition preparation of the present invention is.

[0075] Table 4. Example 10-19 formulations.

[0076]

[0077] Note: The amount of silver yellow extract is calculated by chlorogenic acid, in which chlorogenic acid:baicalin=10:1-1:100.

[0078] The preparation method includes the following steps.

[0079] Put the silver yellow extract of the original medicine powder, non-steroidal anti-inflammatory drugs, antioxidants, metal ion chelating agents, beef flavor or fish meat flavor, and lactose in an oven, dry at 40 °C for 2 h, take them out, and pass through 120-mesh nylon sieves . Take an appropriate amount of lactose and grind it in a mortar to make the inner wall saturated, then pour it out, put the silvery yellow extract and non-steroidal anti-inflammatory drugs in the mortar and grind them evenly, and gradually add antioxidants, metal Grind the ion ...

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Abstract

The invention discloses a compound antipyretic-analgesic and anti-inflammatory drug composition preparation for livestock and application thereof, belongs to the field of drugs for livestock, and specifically relates to a medicinal composition containing non-steroidal anti-inflammatory drugs and honeysuckle and scutellaria baicalensis extracts (honeysuckle extract chlorogenic acid and scutellariabaicalensis extract baicalin). The medicinal composition comprises the following active components in parts by mass: 1-1,000 parts of non-steroidal anti-inflammatory drugs, and 1-100 parts of honeysuckle and scutellaria baicalensis extracts. The medicinal preparation can be one or combination of injection, syrup, oral solution and other liquid preparations, common tablets, dispersible tablets, sustained release tablets, capsules, granules, powder and other solid preparations, ointments, paste, gel and other semi-solid preparations. The compound antipyretic-analgesic and anti-inflammatory drugcomposition preparation is obvious in coordination effect in animal antipyretic-analgesic and anti-inflammatory sides and can effectively reduce adverse effect of the medicine; the compound antipyretic-analgesic and anti-inflammatory drug composition preparation is obvious in treatment effect, stable in quality, high in safety, simple in preparation method, and suitable for industrial production.

Description

technical field [0001] The invention relates to a veterinary compound antipyretic, analgesic and anti-inflammatory drug composition preparation and application thereof. It belongs to the field of veterinary medicine. Background technique [0002] Antipyretic and analgesic anti-inflammatory drugs, also known as nonsteroidal anti-inflammatory drugs (NSAIDs), are a class of drugs that have antipyretic and analgesic effects, and most of them also have anti-inflammatory and anti-rheumatic effects . Since aspirin was first synthesized in 1898, more than 100 kinds of NSAIDs have been listed on the market for more than 100 years; according to the chemical structure, they can be divided into salicylic acid, aniline, pyrazolone, indole acetic acid, ortho Aminobenzoic acids and aryl alkanoic acids, among which anilines basically do not have anti-inflammatory and anti-rheumatic effects. NSAIDs have different chemical structures, but they all reduce the synthesis of prostaglandins by ...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/7048A61K31/216A61P29/00
CPCA61K31/216A61K31/7048A61K45/06A61P29/00A61K2300/00
Inventor 张凌屈梦珂韩剑锋
Owner 四川吉星动物药业有限公司
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