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Hypoglycemic and liver-protecting composition based on multi-path regulation mechanism

A composition and hypoglycemic technology, which is applied in the direction of drug combination, food science, organic active ingredients, etc., can solve the problems of high viscosity and low solubility, and achieve good functions, lower blood sugar, and protect liver function

Active Publication Date: 2020-09-29
NINGBO BAIERMA BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because KGM has defects such as high degree of molecular polymerization, high viscosity, and low solubility, the application of natural KGM is limited to a certain extent.

Method used

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  • Hypoglycemic and liver-protecting composition based on multi-path regulation mechanism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A hypoglycemic and liver-protecting composition, which is composed of rehmannia oligosaccharides and mannan oligosaccharides, and its composition ratio can be the following combinations, as shown in Table 1:

[0035] Table 1

[0036] group Rehmannia oligosaccharides (parts by weight) Mannooligosaccharides (parts by weight) Composition A 20 80 Composition B 80 20 Composition C 50 50 Composition D 60 40

[0037] The source of rehmannia oligosaccharides: purchased from Shaanxi Panier Biotechnology Co., Ltd. pioneer, HPLC detection, content 80%.

[0038] The source of manno-oligosaccharides: the inventor prepared according to the method described in Chinese invention patent CN201110305324.2, liquid chromatography and mass spectrometry detection, total sugar: ≧99.5%; functional ingredients manna 2 sugar ~ manna 10 sugar: ≧98.0%; Among them, mannose 4 sugars to mannose 8 sugars account for more than 85%.

[0039] The preparation ...

Embodiment 2

[0045]The hypoglycemic and liver-protecting composition prepared in the above-mentioned Example 1 was used below to investigate its hypoglycemic and liver-protecting effects on mice through experiments.

[0046] Efficacy experiment-hypoglycemic efficacy experiment

[0047] Select healthy rats with similar size and shape, fast for 12 hours after adaptive feeding for one week, and inject STZ (dissolved in 0.1mol / L citric acid-sodium citrate buffer solution with pH 4.5) once at a concentration of 120mg / kg , stored in the dark and in an ice bath, and ready-to-use), after 3 days, blood was taken from the tail to measure blood sugar, and the diabetes model was considered successful if the blood sugar value was ≥ 14.2 mmol / L. The successfully modeled rats were randomly divided into 5 groups, 10 in each group, respectively model group, metformin group, rehmannia oligosaccharide group, mannan oligosaccharide group, composition A group, composition B group, composition C Group, composi...

Embodiment 3

[0063] According to the requirements of the "General Rules for Formula Foods for Special Medical Purposes", combined with the physical characteristics of diabetic patients, a hypoglycemic and liver-protecting incomplete nutritional formula food, including the following components by weight: rehmannia oligosaccharides 42g, mannan oligosaccharides 28g, collagen peptide 10g, multiple amino acids 10g, multiple vitamins 6g, multiple minerals 4g.

[0064] The preparation method of the above-mentioned hypoglycemic and liver-protecting incomplete nutritional formula food is as follows:

[0065] (1) carry out sterilizing treatment to each component adopting ultraviolet irradiation;

[0066] (2) Components are passed through a 60-mesh sieve, and then weighed according to the weight of each component in the formula;

[0067] (3) Place the weighed components together in a mixer to mix evenly, and pass through a 60-mesh sieve;

[0068] (4) Quantitatively distribute the product obtained a...

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Abstract

The invention discloses a composition with effects of decreasing blood sugar and protecting liver. The composition at least comprises the following components in parts by weight: 20-80 parts of rehmannia glutinosa oligosaccharides and 20-80 parts of manno-oligosaccharides. According to the composition disclosed by the invention, the rehmannia glutinosa oligosaccharides and manno-oligosaccharides are simultaneously used, and due to the anatomical structures and functions of the intestinal tract and liver as well as intestinal microecological balance, the gut-liver axes are mutually influenced under multiple mechanisms so as to form strong balanced synergistic effects. Therefore, the composition has the advantages that the effects of decreasing blood sugar, maintaining the normal blood glucose level and protecting the liver are obviously improved when being compared with those of any of the rehmannia glutinosa oligosaccharides or manno-oligosaccharides.

Description

technical field [0001] The invention belongs to the fields of medical treatment, health care and food, and in particular relates to a blood sugar-lowering and liver-protecting composition based on a multi-path regulation mechanism. Background technique [0002] Safety and health are the focus of the world in the 21st century. Diabetes is ranked third after tumors and cardiovascular and cerebrovascular diseases, and is one of the chronic diseases that seriously endanger human health. Diabetes mellitus is a series of carbohydrate, lipid, and protein metabolic disorder syndromes caused by insufficient insulin secretion or insulin resistance in the body. Fat metabolism disorder caused by diabetes affects liver function, causing liver enlargement, abnormal liver function, and even liver cirrhosis. The main treatment methods for diabetes at home and abroad are artificial injection of insulin or oral hypoglycemic drugs, but these treatment methods are difficult to adjust the dosa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/702A61K31/715A61P3/10A61P1/16A23L33/125
CPCA23L33/125A23V2002/00A61K31/702A61K31/715A61P1/16A61P3/10A61K2300/00A23V2200/30A23V2200/328
Inventor 钱金宏卢晓会钱乾向立军钱勇
Owner NINGBO BAIERMA BIOLOGICAL TECH CO LTD
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