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Preservation method of lactic acid bacteria strain

A technology for preservation of lactic acid bacteria and strains, applied in the direction of bacteria, preservation of microorganisms, and methods based on microorganisms, etc., can solve the problems of inability to preserve for a long time again, and achieve the effects of simple and easy preservation methods, simple recovery, and simple use methods

Inactive Publication Date: 2018-11-20
GANSU ACAD OF SCI INST OF BIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of preservation method of lactic acid bacteria strain, to solve the problem that existing method can't preserve for a long time again

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preservation medium was prepared, and the composition of Lactobacillus preservation medium was 10 g of peptone, 8 g of beef extract powder, 2 g of yeast extract powder, 20 g of glucose, 2 g of dipotassium hydrogen phosphate, 2 g of diammonium hydrogen citrate, and sodium acetate. 5 g, 0.2 g magnesium sulfate, 0.04 g manganese sulfate, 20 g calcium carbonate, 2 g Tween-80, and 1000 g water, pH 7.0, sterilized by pressurized steam at 121°C for 15 minutes, and set aside.

[0021] Lactobacillus delbrueckii subsp. bulgaricus ( Lactobacillus delbrueckii subsp. bulgaricus ) culture preparation, insert Lactobacillus delbrueckii subsp. bulgaricus into Lactobacillus preservation medium, when the pH value of the culture solution is lower than 5.0, adjust the pH to 6.5 with sodium hydroxide solution, and cultivate at 37°C for 24 h , to terminate the cultivation. Centrifuge the culture liquid of Lactobacillus delbrueckii subsp. bulgaricus to collect the bacterial cells. Set the t...

Embodiment 2

[0023] Preservation medium was prepared, and the composition of lactococcus preservation medium was 5 g of soybean peptone, 5 g of peptone, 2.5 g of casein peptone, 3 g of yeast extract powder, 3 g of beef extract powder, 10 g of lactose, 0.5 g of sodium ascorbate, and 0.5 g of glycerol phosphate Sodium 20g, magnesium sulfate 0.3g, calcium carbonate 20g and water 1000g, pH value 7.0, sterilized by pressurized steam at 121°C for 15 minutes, set aside.

[0024] Streptococcus thermophilus culture ( Streptococcus thermophilus) preparation, the Streptococcus thermophilus species were inserted into the Lactococcus preservation medium, when the pH value of the culture solution was lower than 5.0, the pH was adjusted to 6.5 with sodium hydroxide solution, and the culture was terminated after 20 h at 42°C. Centrifuge the culture liquid of Streptococcus thermophilus to collect the bacteria, set the temperature of the centrifuge to 4°C, the centrifugation speed to 6000 r / min, and the ce...

Embodiment 3

[0026] Preservation medium was prepared, and the composition of Lactobacillus preservation medium was 5 g of peptone, 3 g of beef extract powder, 6 g of yeast extract powder, 5 g of glucose, 1 g of dipotassium hydrogen phosphate, 1 g of diammonium hydrogen citrate, and 3 g of sodium acetate. g, 0.1 g magnesium sulfate, 0.02 g manganese sulfate, 10 g calcium carbonate, 1 g Tween-80 and 1000 g water, pH 6.0, sterilized by pressurized steam at 118°C for 15 minutes, and set aside. Lactobacillus acidophilus ( Lactobacillus acidophilus ) culture preparation, the Lactobacillus acidophilus strains were inserted into the Lactobacillus preservation medium, cultured at 30°C for 36 h, and then the culture was terminated. Centrifuge the culture of Lactobacillus acidophilus to collect the bacteria, set the temperature of the centrifuge to 0°C, the centrifugal speed to 9000 r / min, and the centrifugation time to 10 minutes. After the centrifugation, remove the supernatant and collect the pre...

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Abstract

The invention discloses a preservation method of a lactic acid bacteria strain, and belongs to the field of strain preservation, so as to solve the problem that the conventional method cannot realizelong-term re-preservation. The preservation method comprises the following steps: (1) preparing a lactic acid bacteria strain preservation culture medium; (2) preparing a lactic acid bacteria preservation strain culture; (3) collecting lactic acid bacteria; (4) adding a cryoprotectant into the lactic acid bacteria; (5) preparing a lactic acid bacteria embedding particle; (6) preserving the lacticacid bacteria embedding particle at low temperature. The preservation method has the advantages that the preserved lactic acid bacteria strain is wide in application range, high in survival rate, longin preservation period, convenient to carry and easy and convenient to revive, and the preserved lactic acid bacteria strain can be preserved again and reused after being activated for passage. The preservation method disclosed in the invention effectively guarantees the survival number of the lactic acid bacteria strain during preservation. The preservation method is simple, convenient, feasible, economical and applicable, and also can be used as a reference for the preservation of other bacteria.

Description

technical field [0001] The invention belongs to the field of strain preservation, and in particular relates to a method for preserving lactic acid bacteria strains. Background technique [0002] Lactic acid bacteria are a group of bacteria that can produce large amounts of lactic acid from fermentable carbohydrates. This kind of bacteria is widely distributed in nature and has a wide variety. They are ideal materials for studying classification, biochemistry, genetics, molecular biology, and genetic engineering. It also has extremely high application value in important fields closely related to human life such as health care. Microorganisms are easy to mutate. Therefore, in the process of preservation, the metabolism of microorganisms must be kept in the least active or relatively static state, so that they can not mutate and maintain their viability within a certain period of time. Low temperature, dryness and air isolation are important factors that reduce the metabolic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20C12N1/04C12R1/01
CPCC12N1/04C12N1/20
Inventor 邵建宁彭章普刘彩云麻和平张文齐王洁
Owner GANSU ACAD OF SCI INST OF BIOLOGY