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Multifunctional core-shell structure Fe3O4@TiO2@ZIF-8 nanoparticle medicine carrying system and preparation method thereof

A technology of ZIF-8 and nanoparticles, which is applied in the direction of pharmaceutical formulas, preparations for in vivo tests, anti-tumor drugs, etc., can solve the problems of not very sensitive pH response and low value, and achieve low cost and simple preparation , good biocompatibility effect

Active Publication Date: 2018-11-23
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to many limitations under the irradiation of ultraviolet light, and Fe 3 o 4 @TiO 2 The pH response of Nps is not very sensitive, so its value in clinical application is not very great

Method used

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  • Multifunctional core-shell structure Fe3O4@TiO2@ZIF-8 nanoparticle medicine carrying system and preparation method thereof
  • Multifunctional core-shell structure Fe3O4@TiO2@ZIF-8 nanoparticle medicine carrying system and preparation method thereof
  • Multifunctional core-shell structure Fe3O4@TiO2@ZIF-8 nanoparticle medicine carrying system and preparation method thereof

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Embodiment approach

[0037] A specific embodiment is provided: a multifunctional core-shell structure Fe 3 o 4 @TiO 2 @ZIF-8 nanoparticle preparation method, comprising the following steps:

[0038] 1. Synthesis of Fe 3 o 4 Nanoparticles

[0039] Weigh 2.300g of ferric chloride and 1.200g of ferrous chloride in a container, add 100mL of distilled water to dissolve under mechanical stirring and nitrogen protection, then take 2mL of oleic acid, wait for the temperature to rise to 50°C, and react at a high speed for 3 hours; Then add 3mol / L dilute ammonia water dropwise to adjust the pH value of the system to 13, continue heating to 80°C, and keep warm for 1h; Store in distilled water.

[0040] 2. Synthesis of Fe 3 o 4 @TiO 2 Nanoparticles

[0041] Take out 30mg of Fe synthesized above 3 o 4 In the container, magnetically separate, remove the supernatant, wash with absolute ethanol for 3 times, then add 90mL of absolute ethanol and 30mL of acetonitrile into the flask, ultrasonicate for 5-...

Embodiment 1

[0045] Embodiment 1 discloses a kind of Fc with daunorubicin as antitumor active drug as model 3 o 4 @TiO 2 @ZIF-8 drug loading system; the preferred immobilized concentration of daunomycin is 0.3mg / mL.

[0046] 1. Test Fe 3 o 4 @TiO 2 @ZIF-8-DNM Nps pH responsiveness, Fe 3 o 4 @TiO 2 @ZIF-8-DNMNps particles were dissolved in buffer solutions with different pH values, such as Figure 4 As shown, Fe loaded with daunomycin 3 o 4 @TiO 2 @ZIF-8 drug-loaded particles release daunomycin from nanoparticles very slowly in a neutral environment of pH 7.4, and the total amount of drug released within 96h is only 14.3%, but at pH 5.6, there are 79.01% The drug was released from the drug-loaded nanoparticles, compared with pH 7.4, especially between 1h and 24h, daunomycin was significantly accelerated at pH 5.6. These results indicated that Fe 3 o 4 @TiO 2 @ZIF-8-DNM Nps has good pH responsiveness and will increase the release of daunomycin in tumors.

[0047] 2. Test Fe 3...

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Abstract

The invention discloses a multifunctional core-shell structure Fe3O4@TiO2@ZIF-8 nanoparticle medicine carrying system and a preparation method thereof. The multifunctional core-shell structure Fe3O4@TiO2@ZIF-8 nanoparticle medicine carrying system comprises Fe3O4@TiO2@ZIF-8 nanoparticles and medicine loaded on the nanoparticles, wherein the Fe3O4@TiO2@ZIF-8 nanoparticles use Fe3O4 nanoparticles asa magnetic core; TiO2 is used as an inner layer coated material; ZIF-8 nanoparticles are used as an outer layer coating material; the targeting on the tumor position is high; the medicine availability is improved; the toxic and side effects of the medicine are reduced; the use conditions of medicine and tumor targets can be monitored at any time by an MRI developing technology.

Description

technical field [0001] The invention relates to the field of nano drug-loaded particles, more specifically to a multifunctional core-shell structure Fe 3 o 4 @TiO 2 @ZIF-8 nanoparticle drug-loading system and its preparation method. Background technique [0002] In recent years, the study of nanotechnology has attracted more and more attention from researchers, especially engineering nanomaterials have received very high attention. Engineered nanomaterials such as carbon nanotubes, quantum dots and other magnetic nanoparticles are among the most promising materials, and they are used as a platform for the integrated targeted drug delivery, imaging and monitoring of therapeutic effects in the treatment of cancer. Engineered nanomaterials can be modified by certain chemical or physical methods to have very specific properties, making them fast-tracked into the foreword of rapidly developing nanoscience and technology. Magnetic nanoparticles (MNPs) are an important class of...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/02A61K47/22A61K31/704A61K49/10A61K49/18A61P35/00
CPCA61K9/5115A61K9/5123A61K31/704A61K49/10A61K49/183A61K49/1833A61P35/00
Inventor 沈建良赵平柳敏超钱宇娜
Owner WENZHOU MEDICAL UNIV
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