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Preparation method of high-quality rhizoma gastrodiae capsules

A Gastrodia elata capsule, high-quality technology, applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as difficulty in unilateral preparations, affect product quality, and serious moisture absorption of Gastrodia elata extract, and achieve curative effect Remarkable, simple preparation method, good absorption effect

Inactive Publication Date: 2018-11-23
许发平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the modern clinical process, Gastrodia elata Chinese patent medicine preparations are widely used in the treatment of rheumatic joint diseases, dizziness, headache, neuralgia, etc. At present, there are many researches on Gastrodia elata preparations in China, but most of them are Gastrodia elata mixed with other Chinese medicinal materials. Gastrodia elata has a remarkable medicinal effect. Pharmacological studies have shown that it will inevitably produce other reactions when used in combination with other medicinal materials, which will have a certain impact on its own pharmacology. However, there are few studies on the single preparation of Gastrodia elata at present. Mainly because of the high content of water-soluble components in Gastrodia elata, the prepared Gastrodia elata extract has serious moisture absorption, which affects product quality, and it is difficult to develop a single prescription. Through years of research, I have developed a stable quality Gastrodia elata single prescription

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Take 10kg of Gastrodia elata decoction pieces that meet the regulations, add acrylic resin and water equivalent to 3 times the mass of Gastrodia elata, the amount of acrylic resin added is 1.0% of the mass of Gastrodia elata, heat and reflux for 3 hours, filter, extract 2 times, combine the filtrate, the filtrate Concentrate to a thick paste with a relative density of 1.15 (detected at 50-60°C), dry it into a dry paste, and crush it through an 80-mesh sieve; during the heating and reflux extraction process, intermittent vacuum pumping and vacuum breaking are carried out, and the change of pressure difference is used to promote Mass transfer and more thorough dissolution of the active ingredients of Gastrodia elata; ultrasonic vibration is performed during the heating and reflux extraction process, and the cavitation effect of ultrasonic waves is used to promote mass transfer and more thorough dissolution of the active ingredients of Gastrodia elata.

[0025] 2. Mix Ga...

Embodiment 2

[0027] 1. Take 10kg of Gastrodia elata decoction pieces that meet the regulations, add acrylic resin and water equivalent to 2 times the mass of Gastrodia elata, the amount of acrylic resin added is 0.5% of the mass of Gastrodia elata, heat and reflux for 2 hours, filter, extract once, combine the filtrate, the filtrate Concentrate to a thick paste with a relative density of 1.1 (detected at 50-60°C), dry it into a dry paste, and crush it through an 80-mesh sieve; during the heating and reflux extraction process, intermittent vacuum pumping and vacuum breaking are carried out, and the change of pressure difference is used to promote Mass transfer and more thorough dissolution of the active ingredients of Gastrodia elata; ultrasonic vibration is performed during the heating and reflux extraction process, and the cavitation effect of ultrasonic waves is used to promote mass transfer and more thorough dissolution of the active ingredients of Gastrodia elata.

[0028] 2. Mix Gastro...

Embodiment 3

[0030] 1. Take 10kg of Gastrodia elata decoction pieces that meet the requirements, add acrylic resin and water equivalent to 4 times the mass of Gastrodia elata, the amount of acrylic resin added is 1.5% of the mass of Gastrodia elata, heat and reflux for 4 hours, filter, extract 3 times, combine the filtrate, the filtrate Concentrate to a thick paste with a relative density of 1.2 (detected at 50-60°C), dry it into a dry paste, and crush it through an 80-mesh sieve; during the heating and reflux extraction process, intermittent vacuum pumping and vacuum breaking are carried out, and the change of pressure difference is used to promote Mass transfer and more thorough dissolution of the active ingredients of Gastrodia elata; ultrasonic vibration is performed during the heating and reflux extraction process, and the cavitation effect of ultrasonic waves is used to promote mass transfer and more thorough dissolution of the active ingredients of Gastrodia elata.

[0031] 2. Mix Ga...

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PUM

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Abstract

The invention discloses a preparation method of high-quality rhizoma gastrodiae capsules and particularly relates to a preparation method for extracting effective components through a manner of extracting rhizoma gastrodiae through water. The effective components such as gastrodin and polysaccharide in the rhizoma gastrodiae are high in dissolvability in water, so that the effective components ofthe rhizoma gastrodiae can be fully extracted; acrylic resin is added in the extraction process; the polyhydroxy structure can be combined with the effective components of the rhizoma gastrodiae; thelipid solubility of the effective components of the rhizoma gastrodiae can be improved; the absorption is improved; the rhizoma gastrodiae extract is dried and crushed, then a lactic acid alcohol solution with specific concentration is used for granulating; the character of lactic acid is combined with acrylic resin to form a novel polymer; the novel polymer is coated with rhizoma gastrodiae dry paste powder; the moisture absorption performance is reduced; the product stability is improved; the rhizoma gastrodiae capsules prepared by the preparation method are high in stability, rapid in dissolution and excellent in absorption; the dissolution rate of the rhizoma gastrodiae capsules is not obviously changed under harsh condition, so that the rhizoma gastrodiae capsules are relatively highin stability.

Description

technical field [0001] The invention relates to a preparation method of high-quality Gastrodia elata capsules, belonging to the field of traditional Chinese medicines. Background technique [0002] Gastrodia elata, the name of Chinese herbal medicine. This product is the rhizome of Gastrodia elata. It is harvested in winter and spring, and those picked in winter are called winter hemp, which is of good quality; those picked in spring are called spring hemp, and the quality is not as good as winter hemp. After digging out, remove the stems and fibrous roots on the ground, wash the soil, soak in clean water, wipe off the rough skin in time, then soak in clean water or alum water, boil or steam thoroughly until there are no white spots in the center, take out and dry , sun-dried or oven-dried. Function cures mainly: relieving wind, stabilizing convulsion. Cure dizziness, dark eyes, head wind and headache, numbness of limbs, hemiplegia, astringent speech, and convulsions in ...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/48A61P19/02A61P29/00A61P1/08A61P25/00
CPCA61K36/8988A61K9/1652A61P1/08A61P19/02A61P25/00A61P29/00
Inventor 许发平
Owner 许发平
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