3D printed PCL-Li bone tissue engineering scaffold, and preparation method thereof

A tissue engineering scaffold, bone tissue engineering technology, applied in tissue regeneration, additive processing, medical science and other directions, can solve the problem of pathogen transmission, can not be used repeatedly, can not participate in human metabolism and other problems

Inactive Publication Date: 2018-12-04
NANJING FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Including: 1. Autologous bone transplantation, which is limited by the limitation of its own donors and cannot be used repeatedly in large quantities; 2. Allogeneic bone transplantation, which mainly has problems such as immune rejection, pathogen transmission, and high co

Method used

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  • 3D printed PCL-Li bone tissue engineering scaffold, and preparation method thereof
  • 3D printed PCL-Li bone tissue engineering scaffold, and preparation method thereof
  • 3D printed PCL-Li bone tissue engineering scaffold, and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0038] 1. Preparation of PCL-Li particles

[0039] Dissolve PCL and lithium chloride in tetrahydrofuran at a ratio of 69.65:30.35, and configure a solution with a mass volume ratio of 20%. Put the PCL-Li mixed solution in a rotary evaporator at 80°C in a water bath to suck out the solvent tetrahydrofuran under negative pressure to obtain a PCL-Li mixture, which was shredded to obtain PCL-Li particles with a diameter of about 500 microns.

[0040] 2. Preparation of 3D printed PCL-Li scaffolds

[0041] The PCL-Li particles were heated to 100 °C to become liquid through the heating system of Fused Deposition Modeling (FDM) 3D printing. Extrude the molded fiber bundles, and obtain the 3D printing scaffold through the splicing structure of different layers and angles of the fiber bundles. A scaffold with a square microstructure in which the fibers are stacked at 0-90°. The aperture of the scaffold is 500 microns, square, and the porosity is 70%. The physical picture of the scaffo...

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PUM

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Abstract

The invention discloses a 3D printed PCL-Li bone tissue engineering scaffold, and a preparation method thereof. According to the preparation method, epsilon-caprolactone PCL and lithium chloride are taken as raw materials of the 3D printed PCL-Li bone tissue engineering scaffold, 3D printing technology is adopted to prepare the 3D printed PCL-Li bone tissue engineering scaffold. After of implantation of the 3D printed PCL-Li bone tissue engineering scaffold into human body, PCL is degraded gradually as a biologically absorbable material, Li is released to promote osteochondral osteogenesis; and in addition, a porous structure of the 3D printed PCL-Li bone tissue engineering scaffold is capable of inducing bone ingrowth, and repairing of bone defects caused by bone wound, tumor, and infection can be realized. The 3D printed PCL-Li bone tissue engineering scaffold is simple and reliable in structure; the appearance and the microstructure are controllable; the mechanical properties are reliable; ion release properties are controllable; implantation is convenient; wound is small; and cost is low.

Description

technical field [0001] The invention belongs to the field of bone tissue repair and reconstruction, and relates to a 3D printed PCL-Li bone tissue engineering support and a preparation method thereof. Background technique [0002] Clinically, bone defects caused by trauma, tumors, and infections are very common. Every year, a large number of patients with bone tissue defects in my country need surgical treatment. Finding bone tissue engineering repair materials with good biological properties has always been a hot spot in orthopedic research. How to find more and better bone tissue regeneration repair materials to repair human life and recreate health has become the common pursuit and tireless pursuit of many scientists around the world. research impetus. [0003] Although there are many treatments for bone defect repair, these methods generally have many problems such as few sources, many complications, immune rejection and iatrogenic infection, especially for the treatmen...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/50A61L27/54A61L27/56A61L27/58B33Y10/00B33Y70/00
CPCA61L27/446A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/412A61L2430/02B33Y10/00B33Y70/00C08L67/04
Inventor 王黎明姚庆强徐燕李佳怡
Owner NANJING FIRST HOSPITAL
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