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Preparation method for oral liquid of Rhizoma Gastrodiae

A Gastrodia elata oral liquid and the technology of Gastrodia elata, which are applied in the field of preparation of Gastrodia elata oral liquid, can solve the problems such as the poor clarity of the active ingredients of Gastrodia elata, which cannot meet the quality requirements of oral liquid dosage forms, the single active ingredient of Gastrodia elata, and the high cost of purification. The effect of original flavor, good clarity and easy industrial production

Inactive Publication Date: 2018-12-18
YUNNAN LONGRUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the traditional water extraction, alcohol precipitation or heat reflux extraction of Gastrodia elata, on the one hand, the obtained Gastrodia elata has a single active ingredient, the yield is low, the loss of gastrodin is large, and the purification cost is high, which is not conducive to production; The quality requirements of oral liquid dosage form; and the high-purity gastrodin that is decomposed and synthesized by modern technology, on the one hand, has a single component and the cost is very high; technical problems in development

Method used

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  • Preparation method for oral liquid of Rhizoma Gastrodiae
  • Preparation method for oral liquid of Rhizoma Gastrodiae
  • Preparation method for oral liquid of Rhizoma Gastrodiae

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1: The preparation method of this Gastrodia elata oral liquid is as follows:

[0037] (1) Take 1000g of Gastrodia elata medicinal material, crush it to 10-15 meshes, add 1.0% of Gastrodia elata weight combined biological enzymes (4000U / g α-amylase, 10000U / g cellulase, 30000U / g pectinase by weight mass ratio 9:1:1), purified water 9 times the weight of Gastrodia elata, after mixing, adjust the pH value to 5.2 with citric acid solution, and enzymatically hydrolyze at 60°C for 30 minutes;

[0038] (2) The gastrodia elata and its solution after enzymatic hydrolysis were transferred to an ultrasonic extraction tank. The ultrasonic frequency was controlled at 40kHz. The ultrasonic extraction was processed at 50°C for 1.5h in the first stage, and 15min in the latter stage of extraction at 100°C, filtered, and the filtrate was collected. Gastrodia elata water extract;

[0039] (3) Add 0.95% chitosan by weight to Gastrodia elata water extract, stir evenly, let stand,...

Embodiment 2

[0042] Embodiment 2: The preparation method of this Gastrodia elata oral liquid is as follows:

[0043] (1) Take 1000g of Gastrodia elata medicinal material, crush it to 20 mesh, add 1.2% of Gastrodia elata weight combined biological enzyme (4000U / g α-amylase, 10000U / g cellulase, 30000U / g pectinase by mass ratio 8:1:1 ratio), purified water 6 times the weight of Gastrodia elata, after mixing, adjust the pH value to 5.5 with citric acid solution, and enzymatically hydrolyze at 50°C for 45 minutes;

[0044] (2) The gastrodia elata and its solution after enzymatic hydrolysis were transferred to an ultrasonic extraction tank, and the ultrasonic frequency was controlled at 50kHz. The ultrasonic extraction was processed at 60°C for 1.0h in the first stage, and 10min at 90°C in the latter stage, filtered, and the filtrate was collected. Gastrodia elata water extract;

[0045] (3) Add 0.8% chitosan by weight to Gastrodia elata water extract, stir evenly, let stand, refrigerate for 15...

Embodiment 3

[0048] Embodiment 3: The preparation method of this Gastrodia elata oral liquid is as follows:

[0049] (1) Take 1000g of Gastrodia elata medicinal material, crush it to 10 meshes, add 1.5% of Gastrodia elata weight combined biological enzymes (4000U / g α-amylase, 10000U / g cellulase, 30000U / g pectinase by mass ratio 10:1:1 ratio), purified water 8 times the weight of Gastrodia elata, after mixing, adjust the pH value to 6 with citric acid solution, and enzymatically hydrolyze at 55°C for 40 minutes;

[0050] (2) The gastrodia elata and its solution after enzymatic hydrolysis were transferred to an ultrasonic extraction tank, and the ultrasonic frequency was controlled at 60kHz. The ultrasonic extraction was processed at 55°C for 1.2h in the first stage, and 12min in the latter stage at 95°C, filtered, and the filtrate was collected. Gastrodia elata water extract;

[0051] (3) Add 1% chitosan by weight to Gastrodia elata water extract, stir evenly, let stand, refrigerate for 15...

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Abstract

The invention discloses a preparation method for the oral liquid of Rhizoma Gastrodiae. According to the method, enzymatic hydrolysis, ultrasonic treatment, flocculation, centrifugation and membrane separation technologies are adopted to remove impurities, improve clarity, and efficiently extract the functional components of Rhizoma Gastrodiae; and the method of the invention avoids concentrationand drying, so the functional components of Rhizoma Gastrodiae are prevented from oxidation and decomposition, and the content of gastrodin is increased by 25-37% compared to the prior art. The oral liquid of Rhizoma Gastrodiae in the invention is rich in various functional components which produce synergistic effect, so the oral liquid of Rhizoma Gastrodiae is capable of developing intelligence,tonifying the brain, preventing and treating dementia, improving sleep, growth and development, enhancing immunity, helping the improvement of memory functions, assisting in blood pressure lowering and resisting vertigo, epilepsy, convulsion and rheumatism and has other health care effects; moreover, the oral liquid of Rhizoma Gastrodiae is high in yield and low in energy consumption and production cost; experimental results prove that the oral liquid of Rhizoma Gastrodiae is safe and effective and has no toxic and side effect; and the preparation method is simple in preparation process and suitable for industrial production and marketing application.

Description

technical field [0001] The invention relates to a preparation method of Gastrodia elata oral liquid, belonging to the field of oral liquid preparation. Background technique [0002] Gastrodia elata has a medicinal history of more than 2,000 years in my country. The name, place of origin, shape, collection time, processing and use of Gastrodia elata are recorded in great detail in the herbal medical books of all dynasties in my country. "Shen Nong's Materia Medica" lists it as the top grade; "Compendium of Materia Medica" records: "Chijian is pungent, warm, and non-toxic; long-term use can benefit energy, grow yin and fat, lighten body and increase years, reduce carbuncle, fullness of lower limbs, cold Hernia blood. Control all rheumatic numbness, spasm of limbs, infantile epilepsy, convulsions, sharpen waist and knees, strengthen tendons, help yin qi, nourish five consumptive and seven injuries, open blood vessels, open one's senses, take it without taboo." "Rihuazi Materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61K9/08A61P1/08A61P3/00A61P9/12A61P25/00A61P25/08A61P25/28A61P29/00A61P37/04A61K36/80A61K36/69A61K36/20A61K36/254A61K36/888A61K36/258A61K36/725
CPCA61K36/8988A61K9/0095A61K36/20A61K36/254A61K36/258A61K36/69A61K36/725A61K36/80A61K36/888A61K2236/19A61K2236/53A61P1/08A61P3/00A61P9/12A61P25/00A61P25/08A61P25/28A61P29/00A61P37/04A61K2300/00
Inventor 焦家良胡庆普付翠花
Owner YUNNAN LONGRUN PHARMA
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