Preparation method and application of hollow composition template molecularly imprinted polymer micro-shell

A technology of molecular imprinting and combined templates, applied in separation methods, alkali metal compounds, chemical instruments and methods, etc., can solve the problems of limiting the application range of hollow molecular imprinting materials, and achieve the effect of fast adsorption rate and good selectivity

Inactive Publication Date: 2018-12-21
DALIAN POLYTECHNIC UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hollow molecularly imprinted materials can only selectively adsorb a class of compounds with similar structures, which greatly limits the application range of hollow molecularly imprinted materials.

Method used

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  • Preparation method and application of hollow composition template molecularly imprinted polymer micro-shell
  • Preparation method and application of hollow composition template molecularly imprinted polymer micro-shell
  • Preparation method and application of hollow composition template molecularly imprinted polymer micro-shell

Examples

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preparation example Construction

[0031] A method for preparing a hollow combined template molecularly imprinted polymer microshell, comprising the following steps:

[0032] S1. Preparation of polystyrene nanoparticles: First, nitrogen gas is introduced into an aqueous solution of sodium bicarbonate with a concentration of 1-2 mg / mL, and after being heated in a water bath to 55°C-65°C, acrylic acid, styrene and ammonium persulfate are added in sequence, The weight ratio of sodium bicarbonate aqueous solution, acrylic acid, styrene, and ammonium persulfate is: (80-120): (0.5-1.5): (4.0-6.0): (0.05-0.1). The reaction system is mechanically stirred at 350-450rmp, polymerized at 68-72°C for 15-25h, and centrifuged at 8000-10000rpm for 5-10min at room temperature to remove the supernatant to obtain polystyrene nanoparticles; wash with ethanol Polystyrene nanoparticles are dried 3 to 5 times at 40 to 60°C to constant weight for later use;

[0033] S2. Preparation of pre-assembly solution: use sulfadiazine and cipro...

Embodiment 1

[0038] This example relates to a method for preparing a hollow combined template molecularly imprinted polymer microshell that is selective for sulfonamide antibiotics and quinolone antibiotics.

[0039] A method for preparing a hollow combined template molecularly imprinted polymer microshell (h-MIMs), comprising the following steps:

[0040] S1. Preparation of polystyrene nanoparticles: prepare monodisperse carboxylic acid-modified polystyrene nanoparticles by emulsion polymerization; first, add 100 g of sodium bicarbonate aqueous solution with a concentration of 1.5 mg / mL into a three-necked bottle and pass through Inject nitrogen, heat up to 60°C in a water bath, add 1g of acrylic acid, 5g of styrene and 0.08g of ammonium persulfate in sequence, and polymerize at 70°C for 20h under mechanical stirring at 400rmp, centrifuge at 10,000rpm for 10min at room temperature, and remove the upper layer clear liquid to obtain polystyrene nanoparticles; wash the polystyrene nanopartic...

Embodiment 2

[0046] In order to verify the selective adsorption performance of the h-MIMs prepared in the examples of the present invention on template molecules, molecularly imprinted materials were prepared as a control according to the following method.

[0047] 1. The preparation of hollow non-molecularly imprinted microshells (h-NIMs) adopts the following steps:

[0048] ① Preparation of carboxylic acid-modified polystyrene nanoparticles: the method is the same as step S1 of Example 1 of the present invention;

[0049] ② Preparation of non-molecularly imprinted nanospheres: Take 0.4g of polystyrene nanoparticles prepared in step ① and disperse them in 100g, 0.25g mL -1 In the sodium lauryl sulfate aqueous solution, emulsify under the action of stirring for 24 hours; Subsequently, add 6g divinylbenzene and 0.08g azobisisobutylcyanide, initiate polymerization reaction; In order to improve the morphology characteristic of preparation material, The polymerization reaction was first react...

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Abstract

The invention discloses a preparation method and application of a hollow composition template molecularly imprinted polymer micro-shell having a selective absorption effect on sulfanilamide and quinolone antibiotics. The preparation method of the micro-shell comprises the following steps: preparing polystyrene nano-particles, preparing a pre-assembly solution, preparing molecularly imprinted nanospheres, preparing a hollow polymer material, and removing template molecules. The hollow composition template molecularly imprinted polymer micro-shell prepared by the invention not only has the advantages of being good in molecular imprinted polymer selectivity, but also has the advantages of being large in absorption capacity, rapid in absorption rate, wide in application range and the like compared with other types of molecularly imprinted polymers. The preparation method of the hollow composition template molecularly imprinted material not only can solve the existing bottleneck problems ofthe molecularly imprinted material, but also can significantly broaden the selective absorption range of the hollow molecularly imprinted material, thereby widening the application range of the molecularly imprinted material.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a preparation method and application of a hollow composite template molecularly imprinted polymer microshell with selective adsorption performance for two types of compounds. Background technique [0002] Molecular imprinting technology is a technique for synthesizing molecularly imprinted polymer materials with molecular recognition function. The principle of molecular imprinting is that when template molecules are in contact with polymer material monomers, multiple action points will be formed, and this action will be memorized through the polymerization process. When the template molecule is removed, a cavity with multiple action points matching the spatial configuration of the template molecule is formed in the polymer material, and such a cavity will have selective recognition characteristics for the template molecule and its analogues. Therefore, molecularly imp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30B01D15/00
CPCB01D15/00B01J20/268B01J20/28016
Inventor 赵琪曹天明吕丹丹周大勇宋亮林煦东
Owner DALIAN POLYTECHNIC UNIVERSITY
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