Alginate-bonding composite anti-adhesion mesh and preparation method thereof

Abstract

The invention discloses an alginate-bonding composite anti-adhesion mesh and a preparation method thereof. The composite anti-adhesion mesh comprises a supporting layer, a bonding layer and an anti-adhesion layer. The supporting layer is made of a polypropylene mesh, the bonding layer is made of sodium alginate, and the anti-adhesion layer is made of a nano fiber membrane. The preparation method includes: mixing polycaprolactone with polylactide glycolide, dissolving into a solvent to obtain polycaprolactone / polylactide glycolide mixed solution, and subjecting the mixed solution to electrostatic spinning to obtain the nano fiber membrane; coating one surface of the polypropylene mesh with sodium alginate solution, and directly covering the surface with the nano fiber membrane to obtain thecomposite mesh; soaking the composite mesh into calcium chloride solution, and taking out to obtain the alginate-bonding composite anti-adhesion mesh. The composite anti-adhesion mesh is structurallycontrollable, light in weight and soft; by substitution of a traditional anti-adhesion barrier with the nano fiber membrane, material permeability is improved, anti-adhesion time is prolonged, and foreign body reaction is reduced.

Description

technical field [0001] The invention relates to an alginate bonded two-component nanofiber film and PP mesh composite anti-adhesion patch and a preparation method thereof, belonging to the field of biomedical textile materials. Background technique [0002] A hernia is any organ or tissue that leaves its original location and enters another location through normal and abnormal weak points or defects or pores in the human body. According to statistics, hernia has become a frequently-occurring disease in general surgery, and its incidence rate in the world is 3% to 5%, which is higher than any kind of malignant tumor. The main way to treat hernia clinically is to implant a patch that can strengthen or replace weak and damaged fascial tissue. With the popularization of laparoscopic intraperitoneal mesh repair (IPOM), the placement of the mesh has changed from extraperitoneal to intraperitoneal. Since the patch implanted in the abdominal cavity for repair is in direct contact ...

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Problems solved by technology

[0004] Existing patents on electrospinning composite patches include: 1. Polypropylene / polyvinylidene fluoride composite hernia patch, which uses electrospinning technology to spray polyvinylidene fluoride solution on plasma-modified polypropylene A composite patch is formed on the braided layer, but on the one hand, the fibrous membrane is a non-absorbable material, and the inflammatory reaction caused by foreign body reaction is relatively large; on the other hand, the fibrous membrane and the braided layer are not bonded by adhesive and are easy to separate; The patch (publication number CN106581786A) is a functional patch obtained by thermally fusing a fibrous membrane with drug-loaded particles and a non-degradable polymer mesh, but the thermal fusion temperature is relatively high (100-200°C), so it is not applicable The functional layer is a polymer material with a low melting point, such as polycaprolactone; 3, the electrospun film-coated composite pelvic bottom patch (publication number CN105708581A), is to bond the electrospun nanofibers to the coated adhesive ( One side of the polypropylene patch with a mass percentage concentration of 8% fluorine rubber-acetone solution) forms a composite patch, but the biocompatibility and safety of the adhesive are not good

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